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公开(公告)号:US3943063A
公开(公告)日:1976-03-09
申请号:US320180
申请日:1973-01-02
申请人: Masataka Morishita , Yoshihito Inaba , Mitsuru Fukushima , Sadami Kobari , Akiho Nagata , Jinnosuke Abe
发明人: Masataka Morishita , Yoshihito Inaba , Mitsuru Fukushima , Sadami Kobari , Akiho Nagata , Jinnosuke Abe
IPC分类号: C09J7/00 , A01N25/28 , A23L1/00 , A23L3/00 , A61K9/16 , A61K9/50 , B01J13/08 , B01J13/12 , C05G3/00 , C09B67/08 , C11B9/00 , C12N11/04 , B01J13/02
CPC分类号: B01J13/08 , A61K9/1694 , A61K9/50 , A61K9/5089 , B01J13/12 , C12N11/04 , Y10T428/2984 , Y10T428/2987 , Y10T428/2989
摘要: Microcapsules are made by (a.) dispersing or dissolving a core substance in a film-forming polymer solution, (b.) emulsifying in fine droplets the resulting dispersion or solution in a vehicle which is poorly miscible with the solvent of the polymer solution and which doesn't dissolve said polymer to prepare an emulsion, and (c.) adding to the emulsion a non-solvent for the polymer wherein the non-solvent is miscible with the solvent, poorly miscible with the vehicle, and does not dissolve the polymer, whereby the solvent is removed by being absorbed by non-solvent emulsion droplets to precipitate the polymer film around the core substance.
摘要翻译: 微胶囊通过(a。)将核心物质分散或溶解在成膜聚合物溶液中制成,(b。)将细小的液滴乳化成所得到的分散体或溶液在与聚合物溶液的溶剂不易混溶的载体中, 其不溶解所述聚合物以制备乳液,和(c)向所述乳液中加入用于所述聚合物的非溶剂,其中所述非溶剂与所述溶剂混溶,与所述载体不易混溶,并且不溶解 聚合物,由此通过被非溶剂乳液液滴吸收除去溶剂以使聚合物膜围绕核心物质沉淀。
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公开(公告)号:US3935193A
公开(公告)日:1976-01-27
申请号:US102556
申请日:1970-12-29
申请人: Jinnosuke Abe , Tetsuo Watanabe , Teruo Take , Kentaro Fujimoto , Tadashiro Fujii , Kazuyoshi Nishiie
发明人: Jinnosuke Abe , Tetsuo Watanabe , Teruo Take , Kentaro Fujimoto , Tadashiro Fujii , Kazuyoshi Nishiie
IPC分类号: C07D499/00 , C07D499/04 , C07D499/44 , C07D99/16
CPC分类号: C07D499/00 , Y02P20/55
摘要: Novel diacyl penicillins of the formula ##EQU1## wherein R is alkyl, cycloalkyl, aryl, aralkyl, phenoxyalkyl, heterocyclic carboxyl excepting isoxazole carboxyl derivatives, or ##SPC1##In which benzene ring A may optionally be substituted andB represents a protective group for the amino group, and X is a protective group for the carboxyl group, are produced by reacting a benzyl penicillin ester of the formula ##EQU2## wherein X is as defined above, with a chlorinating agent in the presence of tertiary organic base to obtain an imide chloride group-incorporated compound of the formula ##EQU3## and then reacting the compound of the last-named formula with carboxylate of the formulaR-COOM (IV)wherein M is a metal atom, and R is as defined above.
摘要翻译: 式O CH2-C的新型二酰基青霉素O CH2-C ANGLE S ANGLE CH3 N-CH-CHC ANGLE |||CH3 RC ANGLE ||| O||| O = C-N --- CH-COOX(I)其中R 或烷基,环烷基,芳基,芳烷基,苯氧基烷基,除异恶唑羧基衍生物以外的杂环羧基,或其中任选取代的苯甲烯环,B表示氨基的保护基,X为羧基的保护基, 通过使式S ANGLE CH3 CH2-CO-NH-CH-CHC ANGLE |||CH3 O = C-N --- CH-COOX(II)的苄基青霉素酯反应制备,其中X如上定义, 在叔有机碱的存在下与氯化剂反应,得到式I化合物的酰亚胺氯化物基团化合物。ANGLE CH3 CH2-C = N-CH-CHC ANGLE ||| CH3 ClO = C-N --- CH-COOX,(III),然后使最后命名的化合物与式R-COOM(Ⅳ)的羧酸酯反应,其中M是金属原子,R如上定义。
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