公开(公告)号：US20050209464A1

公开(公告)日：2005-09-22

申请号：US10995559

申请日：2004-11-24

Applicant: Thierry Bordier ,  Jinzhu Xu

Inventor： Thierry Bordier ,  Jinzhu Xu

IPC: A61K8/49 ,  A61Q5/10 ,  C07D207/12 ,  C07D207/14 ,  C07D209/36 ,  C07D403/04 ,  C09B51/00

CPC classification number: C07D403/04 ,  A61K8/4946 ,  A61Q5/10 ,  C07D207/12 ,  C07D207/14 ,  C09B51/00

Abstract: A process for preparing an optically active 1-(4-nitrophenyl)-3-pyrrolidinol derivative corresponding to formula (I) below: para-Phenylenediamine derivatives substituted by a chiral pyrrolidinyl group, of formula (II), and their addition salts: A dyeing composition comprising a para-phenylenediamine derivative of formula (II). A method of oxidation-dyeing keratin fibers which employs said composition. Multicompartment devices in which a first compartment contains the said dyeing composition and a second compartment contains an oxidizing agent.

Abstract translation: 制备相应于下式（I）的光学活性1-（4-硝基苯基）-3-吡咯烷醇衍生物的方法：由式（II）的手性吡咯烷基取代的对苯二胺衍生物及其加成盐：A 包含式（II）的对苯二胺衍生物的染色组合物。 使用所述组合物的氧化染色角蛋白纤维的方法。 多间隔装置，其中第一隔室包含所述染色组合物，第二隔室含有氧化剂。

公开(公告)号：US6130212A

公开(公告)日：2000-10-10

申请号：US329755

申请日：1999-06-10

Applicant: Jinzhu Xu ,  Georges Appere ,  Jean Chaudiere ,  Jean-Claude Yadan

Inventor： Jinzhu Xu ,  Georges Appere ,  Jean Chaudiere ,  Jean-Claude Yadan

IPC: A61K33/04 ,  C07D293/10 ,  C07D293/12 ,  C07J51/00 ,  A61K31/58 ,  A61K31/395 ,  A61K31/41

CPC classification number: C07D293/12 ,  C07D293/10 ,  C07J51/00

Abstract: Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.

Abstract translation: 由下式I表示的化合物：其中：R 1至R 5可以具有其中烷基，取代或未取代的芳基，m等于0或1的各种含义，X选自（​​CR 6 R 7）n，其中n = 0或1，并公开CO。 这些化合物可用作抗肿瘤药物，特别是具有促氧化活性。

公开(公告)号：US07126007B2

公开(公告)日：2006-10-24

申请号：US10995558

申请日：2004-11-24

Applicant: Thierry Bordier ,  Jinzhu Xu

Inventor： Thierry Bordier ,  Jinzhu Xu

IPC: C07D403/04 ,  C07D207/14 ,  C07D401/04

CPC classification number: C07D231/12 ,  C07D207/12 ,  C07D207/14 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04

Abstract: A process for synthesizing para-phenylenediamine derivative compounds containing a pyrolidinyl group, and substituted by a nitrogenous radical, wherein the para-phenylenediamine derivative compounds are chosen from those of formula (I): Intermediates containing a pyrrolidinyl group bearing a nitrogenous radical are also disclosed herein.

Abstract translation: 一种合成含有吡咯烷基并被含氮基取代的对苯二胺衍生物化合物的方法，其中对苯二胺衍生物化合物选自式（I）化合物：还含有含有含氮基团的含有吡咯烷基的中间体 这里。

公开(公告)号：US06780888B1

公开(公告)日：2004-08-24

申请号：US10111537

申请日：2002-05-24

Applicant: Jinzhu Xu ,  Hervé Richard

Inventor： Jinzhu Xu ,  Hervé Richard

IPC: A61K31341

CPC classification number: A61K8/676 ,  A61K2800/522 ,  A61Q17/00 ,  A61Q19/00 ,  C07F7/0812 ,  C07F7/0838 ,  C07F7/21

Abstract: The invention concerns novel silicon compounds derived from ascorbic acid consisting of a silicon-containing chain or of silanes, comprising at least a radical A of formula (I) wherein: at least one of the radicals L is a divalent radical for fixing A on the silicon chain. The invention further concerns methods for preparing said compounds, compositions, in particular cosmetic or pharmaceutical, containing them, and their use as antioxidant and/or anti-free radical agent, particularly for treating oxidant stress, for treating the effects of exposure to the sun and for preventing ageing.

Abstract translation: 本发明涉及衍生自由含硅链或硅烷组成的抗坏血酸的新型硅化合物，其至少包含式（I）的基团A，其中：基团L中的至少一个是用于将A固定的二价基团 硅链。 本发明还涉及制备所述化合物，组合物，特别是含有它们的化妆品或药物的方法，以及它们作为抗氧化剂和/或抗自由基剂的用途，特别是用于治疗氧化应激，用于治疗暴露于太阳的作用 并防止老化。

公开(公告)号：US6001825A

公开(公告)日：1999-12-14

申请号：US771442

申请日：1996-12-20

Applicant: Jinzhu Xu ,  Georges Appere ,  Jean Chaudiere ,  Jean-Claude Yadan

Inventor： Jinzhu Xu ,  Georges Appere ,  Jean Chaudiere ,  Jean-Claude Yadan

IPC: C07D293/10 ,  C07D293/12 ,  C07J51/00 ,  A61K33/04

CPC classification number: C07D293/12 ,  C07D293/10 ,  C07J51/00

Abstract: Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.

Abstract translation: 由下式I表示的化合物：其中：R 1至R 5可以具有其中烷基，取代或未取代的芳基，m等于0或1的各种含义，X选自（​​CR 6 R 7）n，其中n = 0或1，并公开CO。 这些化合物可用作抗肿瘤药物，特别是具有促氧化活性。

公开(公告)号：US20130231488A1

公开(公告)日：2013-09-05

申请号：US13814539

申请日：2010-10-25

Applicant: Herve Richard ,  Jinzhu Xu ,  Patricio Guerreiro ,  Yuan Wang ,  Jianping Guo

Inventor： Herve Richard ,  Jinzhu Xu ,  Patricio Guerreiro ,  Yuan Wang ,  Jianping Guo

IPC: C07F7/08 ,  C07D249/20

CPC classification number: C07F7/0879 ,  C07D249/20 ,  C07F7/0838

Abstract: The process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds and the process for preparing siloxane compounds containing 2-hydroxyphenyl benzotriazole function are disclosed.

Abstract translation: 公开了制备2-羟基苯基烯基苯并三唑化合物的方法和制备含有2-羟基苯基苯并三唑功能的硅氧烷化合物的方法。

公开(公告)号：US20050209466A1

公开(公告)日：2005-09-22

申请号：US10995558

申请日：2004-11-24

Applicant: Thierry Bordier ,  Jinzhu Xu

Inventor： Thierry Bordier ,  Jinzhu Xu

IPC: C07D207/12 ,  C07D207/14 ,  C07D401/04 ,  C07D521/00 ,  C07D207/46

CPC classification number: C07D231/12 ,  C07D207/12 ,  C07D207/14 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04

Abstract: Process for synthesizing para-phenylenediamine derivative compounds containing a pyrolidinyl group and substituted by a nitrogenous radical, corresponding to the formula (I) below: Intermediates containing a pyrrolidinyl group bearing a nitrogenous radical.

Abstract translation: 对应于下式（I），合成含有吡咯烷基并被氮原子取代的对苯二胺衍生物化合物的方法：含有含氮基团的吡咯烷基的中间体。

公开(公告)号：US6057310A

公开(公告)日：2000-05-02

申请号：US120436

申请日：1998-07-22

Applicant: Jinzhu Xu ,  Georges Appere ,  Jean Chaudiere ,  Jean-Claude Yadan

Inventor： Jinzhu Xu ,  Georges Appere ,  Jean Chaudiere ,  Jean-Claude Yadan

IPC: C07D293/10 ,  C07D293/12 ,  C07J51/00 ,  A61K31/41 ,  C07D421/12

CPC classification number: C07D293/12 ,  C07D293/10 ,  C07J51/00

Abstract: Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.

Abstract translation: 由下式I表示的化合物：其中：R 1至R 5可以具有其中烷基，取代或未取代的芳基，m等于0或1的各种含义，X选自（​​CR 6 R 7）n，其中n = 0或1，并公开CO。 这些化合物可用作抗肿瘤药物，特别是具有促氧化活性。

公开(公告)号：US6056965A

公开(公告)日：2000-05-02

申请号：US929069

申请日：1997-09-15

Applicant: Jean-Claude Y. Yadan ,  Jinzhu Xu ,  Marc E. Moutet ,  Jean R. Chaudiere

Inventor： Jean-Claude Y. Yadan ,  Jinzhu Xu ,  Marc E. Moutet ,  Jean R. Chaudiere

IPC: A23L29/00 ,  A61P39/06 ,  C07D233/84 ,  C07D405/12 ,  A61K7/42 ,  A61K31/415 ,  C07D403/12

CPC classification number: C07D233/84

Abstract: The invention relates to 2-mercaptoimidazole derivatives substituted in the 4(or 5)-position.These 2-mercaptoimidazole derivatives are of the general formula (I) below: ##STR1## wherein: R.sub.1, R.sub.2, R.sub.5, R.sub.7 and R.sub.8 are hydrogen, a lower alkyl, an aralkyl or a substituted aralkyl, wherein at least one of R.sub.1 and R.sub.2 is hydrogen;R.sub.3 is (CH.sub.2).sub.n COR.sub.4, --(CH.sub.2).sub.n N.sup.+ (R.sub.5 R.sub.6 R.sub.7).X.sup.- or --CH.sub.2 CH(COR.sub.4)N.sup.+ (R.sub.5 R.sub.6 R.sub.7).X.sup.- ;R.sub.4 is OR.sub.8, --NHR.sub.5, --.alpha.-amino acid,--NHCH.sub.2 CH.sub.2 SO.sub.3.sup.-.Y.sup.+, --NHCH.sub.2 CH.sub.2 CO.sub.2.sup.- Y.sup.+, --OCH.sub.2 CH.sub.2 N.sup.+ (CH.sub.3).sub.3.X.sup.- ; ##STR2## n=1 or 2; X.sup.31 is an anion of an acid acceptable in cosmetics, pharmaceuticals or foodstuffs; andY.sup.+ is a cation of a base acceptable in cosmetics, pharmaceuticals or foodstuffs.These compounds are valuable as antioxidants and as active principles of pharmaceutical, cosmetic or food compositions with antioxidant activity.

Abstract translation: 本发明涉及在4（或5） - 位取代的2-巯基咪唑衍生物。 这些2-巯基咪唑衍生物具有以下通式（I）：其中：R 1，R 2，R 5，R 7和R 8是氢，低级烷基，芳烷基或取代的芳烷基，其中R 1和R 2中的至少一个是氢 ; R3是（CH2）nCOR4， - （CH2）nN +（R5R6R7）.X-或-CH2CH（COR4）N +（R5R6R7）.X-; R4是OR8，-NHR5，-A-氨基酸，-NHCH2CH2SO3-，Y +，-NHCH2CH2CO2-Y +，-OCH2CH2N +（CH3）3.X-; n = 1或2; X31是化妆品，药​​品或食品中可接受的酸的阴离子; Y +是化妆品，药​​品或食品中可接受的碱的阳离子。 这些化合物作为抗氧化剂和具有抗氧化活性的药物，化妆品或食品组合物的活性成分是有价值的。

公开(公告)号：US09447123B2

公开(公告)日：2016-09-20

申请号：US13814539

申请日：2010-10-25

Applicant: Herve Richard ,  Jinzhu Xu ,  Patricio Guerreiro ,  Yuan Wang ,  Jianping Guo

Inventor： Herve Richard ,  Jinzhu Xu ,  Patricio Guerreiro ,  Yuan Wang ,  Jianping Guo

IPC: C07F7/08 ,  C07D249/20

CPC classification number: C07F7/0879 ,  C07D249/20 ,  C07F7/0838

Abstract: The process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds and the process for preparing siloxane compounds containing 2-hydroxyphenyl benzotriazole function are disclosed.

Abstract translation: 公开了制备2-羟基苯基烯基苯并三唑化合物的方法和制备含有2-羟基苯基苯并三唑功能的硅氧烷化合物的方法。