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公开(公告)号：US5837493A
公开(公告)日：1998-11-17
申请号：US788584
申请日：1997-01-23
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/00 , C07H21/04 , C12N1/20
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides two novel human galectins (designated individually as GAL-5HA and GAL-5HB, and collectively as GAL-5H) and polynucleotides which identify and encode GAL-5H. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding GAL-5H and a method for producing GAL-5H. The invention also provides for use of GAL-5H and agonists, antibodies, or antagonists specifically binding GAL-5H, in the prevention and treatment of diseases associated with expression of GAL-5H. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding GAL-5H for the treatment of diseases associated with the expression of GAL-5H. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding GAL-5H.
摘要翻译： 本发明提供两种新型人半乳凝素（单独命名为GAL-5HA和GAL-5HB，统称为GAL-5H）和识别和编码GAL-5H的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码GAL-5H的核酸序列和产生GAL-5H的方法。 本发明还提供使用GAL-5H和特异性结合GAL-5H的激动剂，抗体或拮抗剂来预防和治疗与GAL-5H表达相关的疾病。 另外，本发明提供了反义分子用于编码GAL-5H的多核苷酸用于治疗与GAL-5H表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合GAL-5H的抗体的诊断测定法。
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公开(公告)号：US6051692A
公开(公告)日：2000-04-18
申请号：US235450
申请日：1999-01-22
申请人： Olga Bandman , Preeti Lal , Joanne R. Petithory
发明人： Olga Bandman , Preeti Lal , Joanne R. Petithory
IPC分类号： A61K38/00 , C07K14/705 , C12N1/21 , C12N15/12 , C07K14/00 , A61K38/17 , C07H21/04 , C07K14/435
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a human retinoid binding protein (Hu-RBP) and polynucleotides which identify and encode Hu-RBP. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of Hu-RBP, as well as diagnostic assays.
摘要翻译： 本发明提供了人类维甲酸结合蛋白（Hu-RBP）和识别和编码Hu-RBP的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体和拮抗剂。 本发明还提供了用于预防和治疗与Hu-RBP表达相关的疾病以及诊断测定法的方法。
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公开(公告)号：US5955305A
公开(公告)日：1999-09-21
申请号：US847724
申请日：1997-04-28
申请人： Olga Bandman , Preeti Lal , Joanne R. Petithory
发明人： Olga Bandman , Preeti Lal , Joanne R. Petithory
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a human retinoid binding protein (Hu-RBP) and polynucleotides which identify and encode Hu-RBP. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of Hu-RBP, as well as diagnostic assays.
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公开(公告)号：US5958725A
公开(公告)日：1999-09-28
申请号：US865336
申请日：1997-05-29
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P35/00 , C07K14/82 , C07K16/32 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/00
摘要： The invention provides a human DPl homolog (DPlh)) and polynucleotides which identify and encode DPlh. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of DPlh.
摘要翻译： 本发明提供人DP1同系物（DP1h））和鉴定和编码DP1h的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与DP1h表达相关的疾病的方法。
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