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公开(公告)号：US20160097749A1
公开(公告)日：2016-04-07
申请号：US14927586
申请日：2015-10-30
Applicant: Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
Inventor： Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
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2.发明授权Methods for isotopically labeling biomolecules using mammalian cell-free extracts 有权使用哺乳动物无细胞提取物同位素标记生物分子的方法公开(公告)号：US08945861B2
公开(公告)日：2015-02-03
申请号：US13565135
申请日：2012-08-02
Applicant: Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
Inventor： Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
IPC: C12P21/00 , G01N33/566 , G01N25/00 , G01N33/68 , C12P21/02
CPC classification number: G01N33/6848 , C12P21/02 , G01N33/58 , G01N2458/15 , G01N2560/00
Abstract: Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed using mammalian cell-free extracts are disclosed. Methods for producing such standards, kits, systems and reagents, relating to the use of isotope-labeled biomolecule as quantification standards in mass spectrometric and nuclear magnetic resonance analysis.
Abstract translation: 在无细胞蛋白质合成系统中生产同位素标记的哺乳动物，包括人类，生物分子，如多肽和蛋白质的方法。 产生具有与生物分子中的天然存在的同位素丰度不同的至少一种同位素的生物分子标准。 公开了使用哺乳动物无细胞提取物表达的生物分子标准物质的方法。 生产与使用同位素标记的生物分子作为质谱和核磁共振分析中的定量标准相关的标准，试剂盒，系统和试剂的方法。
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公开(公告)号：US20130034867A1
公开(公告)日：2013-02-07
申请号：US13565135
申请日：2012-08-02
Applicant: Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
Inventor： Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
CPC classification number: G01N33/6848 , C12P21/02 , G01N33/58 , G01N2458/15 , G01N2560/00
Abstract: Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed using mammalian cell-free extracts are disclosed. Methods for producing such standards, kits, systems and reagents, relating to the use of isotope-labeled biomolecule as quantification standards in mass spectrometric and nuclear magnetic resonance analysis.
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公开(公告)号：US09377469B2
公开(公告)日：2016-06-28
申请号：US14579206
申请日：2014-12-22
Applicant: Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
Inventor： Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
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公开(公告)号：US20150148260A1
公开(公告)日：2015-05-28
申请号：US14579206
申请日：2014-12-22
Applicant: Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
Inventor： Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
Abstract translation: 在使用与报告物偶联的标记肽的质谱法和通用报道分子中，分析物的定量，包括但不限于肽，多肽和蛋白质。
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Patent Agency Ranking
公开(公告)号：US20130105684A1
公开(公告)日：2013-05-02
申请号：US13805059
申请日：2011-07-07
Applicant: Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
Inventor： Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
IPC: G01N33/68
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
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公开(公告)号：US09297808B2
公开(公告)日：2016-03-29
申请号：US13805017
申请日：2011-05-31
Applicant: Joel Louette , John Charles Rogers
Inventor： Joel Louette , John Charles Rogers
IPC: C12Q1/37 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K14/00 , C07K16/00 , C07K17/00 , G01N33/68 , B82Y15/00 , G01N33/532 , H01J49/00
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
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8.发明申请METHODS FOR ISOTOPICALLY LABELING BIOMOLECULES USING MAMMALIAN CELL-FREE EXTRACTS 审中-公开同种异体标记生物分子的方法使用无细胞免疫提取物公开(公告)号：US20150125875A1
公开(公告)日：2015-05-07
申请号：US14583376
申请日：2014-12-26
Applicant: Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
Inventor： Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
CPC classification number: G01N33/6848 , C12P21/02 , G01N33/58 , G01N2458/15 , G01N2560/00
Abstract: Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed using mammalian cell-free extracts are disclosed. Methods for producing such standards, kits, systems and reagents, relating to the use of isotope-labeled biomolecule as quantification standards in mass spectrometric and nuclear magnetic resonance analysis.
Abstract translation: 在无细胞蛋白质合成系统中生产同位素标记的哺乳动物，包括人类，生物分子，如多肽和蛋白质的方法。 产生具有与生物分子中的天然存在的同位素丰度不同的至少一种同位素的生物分子标准。 公开了使用哺乳动物无细胞提取物表达的生物分子标准物质的方法。 生产与使用同位素标记的生物分子作为质谱和核磁共振分析中的定量标准相关的标准，试剂盒，系统和试剂的方法。
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公开(公告)号：US08933396B2
公开(公告)日：2015-01-13
申请号：US13805059
申请日：2011-07-07
Applicant: Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
Inventor： Joel Louette , John Charles Rogers , Scott M. Peterman , Bruno Domon , Elodie Duriez
IPC: G01N33/68 , C07K2/00 , G01N33/532 , B82Y15/00
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
Abstract translation: 在使用与报告物偶联的标记肽的质谱法和通用报道分子中，分析物的定量，包括但不限于肽，多肽和蛋白质。
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公开(公告)号：US20130210051A1
公开(公告)日：2013-08-15
申请号：US13805017
申请日：2011-05-31
Applicant: Joel Louette , John Charles Rogers
Inventor： Joel Louette , John Charles Rogers
IPC: C07K2/00
CPC classification number: G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
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