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    Photocrosslinking of diethyl fumarate/poly(propylene fumarate) biomaterials
    3.
    发明授权
    Photocrosslinking of diethyl fumarate/poly(propylene fumarate) biomaterials 有权
    富马酸二乙酯/聚（富马酸丙烯酯）生物材料的光交联

    公开(公告)号：US06753358B2

    公开(公告)日：2004-06-22

    申请号：US10185473

    申请日：2002-06-28

    申请人： John P. Fisher ,  Antonios G. Mikos

    发明人： John P. Fisher ,  Antonios G. Mikos

    IPC分类号： C08F250

    CPC分类号： C08F22/00 ,  A61L27/18 ,  B33Y80/00 ,  C08L67/06

    摘要： A polymer network formed by crosslinking poly(propylene fumarate) with a fumarate derivative. The fumarate derivative is one in which the PPF is soluble, is preferably an alkyl fumarate, and is more preferably selected from the group consisting of diethyl fumarate, dimethyl fumarate, methyl ethyl fumarate, diisopropyl fumarate, and dibutyl fumarate. The network can be formed by photo-crosslinking and can be porous. In some embodiments, the poly(propylene fumarate) and the fumarate derivative are each present in an amount effective to produce a polymeric network useful for in vivo applications. The network can be formed from an injectable, in situ crosslinkable composite formulation, or can be prefabricated from a crosslinkable composite formulation such as stereolithography, rapid prototyping, injection molding, and extrusion molding.

    摘要翻译： 通过将富马酸（富马酸）与富马酸衍生物交联而形成的聚合物网络。 富马酸盐衍生物是其中PPF是可溶的，优选富马酸烷基酯，更优选选自富马酸二乙酯，富马酸二甲酯，富马酸甲酯，富马酸二异丙酯和富马酸二丁酯。 网络可以通过光交联形成，并且可以是多孔的。 在一些实施方案中，聚（丙烯富马酸酯）和富马酸酯衍生物各自以有效产生可用于体内应用的聚合物网络的量存在。 网络可以由可注射的原位可交联的复合制剂形成，或者可以从可交联的复合制剂例如立体光刻，快速成型，注射成型和挤出成型制成。

    CONTINUOUS DIGITAL LIGHT PROCESSING ADDITIVE MANUFACTURING OF IMPLANTS
    10.
    发明申请
    CONTINUOUS DIGITAL LIGHT PROCESSING ADDITIVE MANUFACTURING OF IMPLANTS 有权
    连续数字加工植物的添加剂制造

    公开(公告)号：US20130304233A1

    公开(公告)日：2013-11-14

    申请号：US13817612

    申请日：2011-08-22

    申请人： H. David Dean ,  Jonathan E. Wallace ,  Antonios G. Mikos ,  Martha Wang ,  Ali Siblani ,  Kyobum Kim ,  John P. Fisher

    发明人： H. David Dean ,  Jonathan E. Wallace ,  Antonios G. Mikos ,  Martha Wang ,  Ali Siblani ,  Kyobum Kim ,  John P. Fisher

    IPC分类号： A61L27/60

    CPC分类号： B29C67/0066 ,  A61L27/50 ,  A61L27/56 ,  A61L27/60 ,  B29C64/135 ,  B33Y30/00 ,  B33Y50/00 ,  B33Y80/00 ,  G02B26/0833

    摘要： A process for additive manufacturing of a resorbable implant to be implanted into a patient includes providing a biocompatible resin including a liquid light-polymerizable material that is resorbable after polymerization and an initiator. The process further includes actuating an additive manufacturing apparatus to expose an amount of the biocompatible resin to light to at least partially cure the exposed amount of biocompatible resin to form a layer of the resorbable implant and actuating the additive manufacturing apparatus to expose at least some additional amount of biocompatible resin to light to at least partially cure the exposed additional amount of biocompatible resin to form an additional layer of the resorbable implant and to at least partially overcure previously cured layers to cause at least some interlayer binding between the previously cured layers and the additional layer.

    摘要翻译： 可植入患者的可再吸收植入物的添加制造方法包括提供生物相容性树脂，其包括在聚合后可再吸收的液体光可聚合材料和引发剂。 该方法还包括致动添加剂制造设备以将一定量的生物相容性树脂暴露于光以至少部分地固化暴露量的生物相容性树脂以形成可再吸收的植入物的层并致动添加剂制造设备以暴露至少一些附加的 生物相容性树脂的量至少部分地固化暴露的额外量的生物相容性树脂以形成另外的可再吸收植入物层，并且至少部分地过度固化先前固化的层，以在先前固化的层之间至少部分层间结合 附加层。