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1.发明申请公开(公告)号：US20090324750A1
公开(公告)日：2009-12-31
申请号：US11916216
申请日：2006-05-30
申请人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
发明人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
CPC分类号： A61K36/185 , A23L33/105 , A23V2002/00 , A61K31/35 , A61K31/352 , A61K36/68 , A61K36/80 , C07H17/04 , A23V2250/21 , A23V2200/324 , A23V2200/304
摘要： The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and cosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
摘要翻译： 本发明涉及包含假单胞菌属植物提取物和从其分离的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平和血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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2.发明申请公开(公告)号：US20120183632A1
公开(公告)日：2012-07-19
申请号：US13427334
申请日：2012-03-22
申请人： Hyeong Kyu LEE , Sei Ryang OH , Kyung Seop AHN , Sang Ku LEE , Joong Ku LEE , Ok Kyoung KWON , Doo Young KIM , Hyouk JOUNG , Gui Hua QUAN , Mi Jin KIM , Bo Young PARK
发明人： Hyeong Kyu LEE , Sei Ryang OH , Kyung Seop AHN , Sang Ku LEE , Joong Ku LEE , Ok Kyoung KWON , Doo Young KIM , Hyouk JOUNG , Gui Hua QUAN , Mi Jin KIM , Bo Young PARK
IPC分类号： A61K36/68 , A61P29/00 , A61P37/08 , A61K31/7048
CPC分类号： A61K36/185 , A23L33/105 , A23V2002/00 , A61K31/35 , A61K31/352 , A61K36/68 , A61K36/80 , C07H17/04 , A23V2250/21 , A23V2200/324 , A23V2200/304
摘要： The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
摘要翻译： 本发明涉及包含假单胞菌属植物提取物和从其中分离出的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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3.发明申请Composition comprising an extract of tiarella polyphylla and tiarellic acid isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权组合物，其包含从其中分离的天竺葵提取物和由其分离的天竺葵酸，其具有抗炎，抗过敏和抗哮喘活性公开(公告)号：US20090148542A1
公开(公告)日：2009-06-11
申请号：US11989053
申请日：2006-07-18
申请人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
发明人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
CPC分类号： C07J53/00 , A23L33/105 , A61K36/185 , Y10S514/826
摘要： The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
摘要翻译： 本发明涉及一种组合物，其中含有天竺葵提取物和从其中分离得到的具有抗炎，抗过敏和抗哮喘活性的天竺葵酸。 Tiarella polyphylla的提取物和从其中分离的tiarellic酸显示对LTC4释放体外试验的抑制作用和对IgE水平和细胞因子（IL-4，IL-5和IL-13）产生，气道高反应性的抑制作用 ，和OVA诱导的哮喘小鼠白细胞浸润。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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4.发明授权Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权药物组合物，其包含假单胞菌长柄菌的提取物和从其分离的梓醇衍生物，其具有抗炎，抗过敏和抗哮喘活性公开(公告)号：US08455541B2
公开(公告)日：2013-06-04
申请号：US13427352
申请日：2012-03-22
申请人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
发明人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
IPC分类号： A61K31/35
CPC分类号： A61K31/7048 , A61K9/2059 , A61K9/4866
摘要： The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
摘要翻译： 本发明涉及包含假单胞菌属植物提取物和从其中分离出的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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5.发明授权Pharmaceutical composition comprising an extract of Pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权药物组合物，其包含假单胞菌属植物提取物和从其分离的梓醇衍生物，其具有抗炎，抗过敏和抗哮喘活性公开(公告)号：US08168235B2
公开(公告)日：2012-05-01
申请号：US11916216
申请日：2006-05-30
申请人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
发明人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
IPC分类号： A61K36/00
CPC分类号： A61K36/185 , A23L33/105 , A23V2002/00 , A61K31/35 , A61K31/352 , A61K36/68 , A61K36/80 , C07H17/04 , A23V2250/21 , A23V2200/324 , A23V2200/304
摘要： The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
摘要翻译： 本发明涉及包含假单胞菌属植物提取物和从其分离的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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6.发明授权Composition comprising an extract of Tiarella polyphylla and tiarellic acid isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权组合物，其包含从其中分离的天竺葵提取物和由其分离的含有抗炎，抗过敏和抗哮喘活性的叶酸公开(公告)号：US07763286B2
公开(公告)日：2010-07-27
申请号：US11989053
申请日：2006-07-18
申请人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
发明人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Joong Ku Lee , Sang Ku Lee , Jung Hee Kim , Doo Young Kim , Gui Hua Quan , Ok Kyoung Kwon , Eun Ah Kim , Soon Ja Choi , Guang Hai Shen , Mi Jin Kim , Bo Young Park , Byung Sun Min , Gyoon Hee Han , Hea Young Park , Gun Cheol Kim , Joo Heon Kim , So Young Kim
CPC分类号： C07J53/00 , A23L33/105 , A61K36/185 , Y10S514/826
摘要： The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
摘要翻译： 本发明涉及一种组合物，其中含有天竺葵提取物和从其中分离得到的具有抗炎，抗过敏和抗哮喘活性的天竺葵酸。 Tiarella polyphylla的提取物和从其中分离的tiarellic酸显示对LTC4释放体外试验的抑制作用和对IgE水平和细胞因子（IL-4，IL-5和IL-13）产生，气道高反应性的抑制作用 ，和OVA诱导的哮喘小鼠白细胞浸润。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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7.发明授权Pharmaceutical composition comprising an extract of Pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity 有权药物组合物，其包含假单胞菌属植物提取物和从其分离的梓醇衍生物，其具有抗炎，抗过敏和抗哮喘活性公开(公告)号：US08974837B2
公开(公告)日：2015-03-10
申请号：US13427334
申请日：2012-03-22
申请人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
发明人： Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
IPC分类号： A61K36/00 , A61K36/185 , A23L1/30 , A61K31/35 , A61K31/352 , A61K36/68 , A61K36/80 , C07H17/04
CPC分类号： A61K36/185 , A23L33/105 , A23V2002/00 , A61K31/35 , A61K31/352 , A61K36/68 , A61K36/80 , C07H17/04 , A23V2250/21 , A23V2200/324 , A23V2200/304
摘要： The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
摘要翻译： 本发明涉及包含假单胞菌属植物提取物和从其中分离出的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。
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公开(公告)号：US20120184499A1
公开(公告)日：2012-07-19
申请号：US13427352
申请日：2012-03-22
申请人： Hyeong Kyu LEE , Sei Ryang-Oh , Kyung Seop AHN , Sang Ku LEE , Joong Ku LEE , Ok Kyoung KWON , Doo Young KIM , Hyouk JOUNG , Gui Hua QUAN , Mi Jin KIM , Bo Young PARK
发明人： Hyeong Kyu LEE , Sei Ryang-Oh , Kyung Seop AHN , Sang Ku LEE , Joong Ku LEE , Ok Kyoung KWON , Doo Young KIM , Hyouk JOUNG , Gui Hua QUAN , Mi Jin KIM , Bo Young PARK
IPC分类号： A61K31/7048 , A61P11/06 , A61P29/00 , A61P37/08
CPC分类号： A61K31/7048 , A61K9/2059 , A61K9/4866
摘要： The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
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