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公开(公告)号:US08257931B2
公开(公告)日:2012-09-04
申请号:US11795078
申请日:2006-01-20
IPC分类号: C07D277/20 , A61P35/04 , G01N33/53 , A61K31/425 , C12Q1/02 , C12N5/02
CPC分类号: C07D277/28 , A61K31/426 , A61K31/515 , C07D237/20 , C07D277/46 , C07D277/50 , C07D277/56 , G01N33/5011 , G01N33/6872 , G01N33/6875 , G01N2500/00
摘要: A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
摘要翻译: 与非肿瘤细胞相比抑制肿瘤细胞增殖的组合物和方法。 还描述了与蛋白质的帽无关翻译相比,筛选抑制帽依赖性翻译的组合物的方法。
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公开(公告)号:US20100144805A1
公开(公告)日:2010-06-10
申请号:US11795078
申请日:2006-01-20
申请人: Gerhard Wagner , Michael Chorev , Nathan Moerke , Huseyin Aktas , José Halperin
发明人: Gerhard Wagner , Michael Chorev , Nathan Moerke , Huseyin Aktas , José Halperin
IPC分类号: A61K31/425 , G01N33/53 , C12Q1/02 , C12N5/02 , C07D277/20 , A61P35/04
CPC分类号: C07D277/28 , A61K31/426 , A61K31/515 , C07D237/20 , C07D277/46 , C07D277/50 , C07D277/56 , G01N33/5011 , G01N33/6872 , G01N33/6875 , G01N2500/00
摘要: A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
摘要翻译: 与非肿瘤细胞相比抑制肿瘤细胞增殖的组合物和方法。 还描述了与蛋白质的帽无关翻译相比,筛选抑制帽依赖性翻译的组合物的方法。
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