公开(公告)号：US20090299387A1

公开(公告)日：2009-12-03

申请号：US12475475

申请日：2009-05-30

申请人： Jose Luis Navia

发明人： Jose Luis Navia

IPC分类号： A61B17/11

CPC分类号： A61B17/12022 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/12127 ,  A61B2017/308 ,  A61B2090/08021 ,  A61B2090/0807

摘要： An apparatus for fluidly isolating a portion of a blood vessel wall from bloodflow at an anastomosis site within a blood vessel is described. An insertion catheter has longitudinally spaced proximal and distal catheter ends and an operative lumen extending therebetween, and is configured for insertion into the blood vessel at an insertion location spaced apart from the anastomosis site. An isolation device is attached to the distal catheter end, and includes a concave working surface bounded by an isolation rim and a bloodflow surface opposite the working surface. The isolation rim is configured to contact at least a portion of the blood vessel longitudinally aligned with, and radially spaced from, the anastomosis site. The bloodflow surface is in contact with bloodflow past the anastomosis site within the blood vessel when the isolation device engages the blood vessel wall. A retention means is attached to the isolation device and in fluid communication with the operative lumen. The retention means is configured to exert force on the blood vessel wall to at least partially engage the blood vessel wall with the isolation device. A method of fluidly isolating a portion of a blood vessel wall from bloodflow at an anastomosis site within a blood vessel is also provided.

摘要翻译： 描述了一种用于在血管内的吻合部位将血管壁的一部分与血液流体隔离的装置。 插入导管具有纵向间隔的近端和远端导管末端以及在其间延伸的手术腔，并且构造成用于在与吻合部位间隔开的插入位置插入血管。 隔离装置连接到远侧导管端，并且包括由隔离边缘限定的凹形工作表面和与工作表面相对的血流表面。 隔离边缘构造成使至少一部分血管与吻合部位纵向对齐并且与其吻合部位径向间隔开。 当隔离装置接合血管壁时，血流表面与血管内的吻合部位接触。 保持装置附接到隔离装置并与操作腔流体连通。 保持装置构造成在血管壁上施加力以至少部分地将血管壁与隔离装置接合。 还提供了在血管内的吻合部位将血管壁的一部分与血液流体隔离的方法。

公开(公告)号：US08512403B2

公开(公告)日：2013-08-20

申请号：US10850508

申请日：2004-05-20

申请人： Jose Luis Navia ,  Jose Antonio Navia ,  Mark S. Goodin

发明人： Jose Luis Navia ,  Jose Antonio Navia ,  Mark S. Goodin

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2466 ,  A61F2/91

摘要： An annuloplasty ring for repairing a cardiac valve includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion between the end portions. The proximal end portion of the support member includes a plurality of wing members that extend from the main body portion. Each of the wing members includes at least one hook member for embedding into a cardiac wall and the valve annulus to secure the annuloplasty ring in the valve annulus. The annuloplasty ring may be expanded into full contact engagement with the annulus of the cardiac valve by an inflatable balloon. Methods for repairing a cardiac valve using the annuloplasty ring are also provided.

摘要翻译： 用于修复心脏瓣膜的瓣环成形术环包括具有相对设置的近端部分和远端部分以及端部之间的主体部分的可扩张支撑部件。 支撑构件的基端部包括从主体部延伸的多个翼构件。 每个翼构件包括至少一个用于嵌入心壁的钩构件和瓣环，以将瓣环成形术环固定在瓣膜环中。 瓣膜成形术环可以通过可充气气囊扩张成与心脏瓣膜的环形物完全接触接合。 还提供了使用瓣环成形术修复心脏瓣膜的方法。

公开(公告)号：US08216303B2

公开(公告)日：2012-07-10

申请号：US12274087

申请日：2008-11-19

申请人： Jose Luis Navia

发明人： Jose Luis Navia

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2/2445 ,  A61F2/2454 ,  A61F2/246 ,  A61F2/2466 ,  A61F2/2496

摘要： An apparatus is provided for treating regurgitation of blood flow through a diseased heart valve. The apparatus includes an annular support member and at least one posterior leaflet support member. The annular support member has an anterior end portion, a posterior end portion, and oppositely disposed first and second intermediate portions extending between the end portions. The at least one posterior leaflet support member is securely connected to the annular support member and is dimensioned to extend across a portion of a free edge of a posterior valve leaflet. The posterior leaflet support member comprises an arcuate center portion integrally formed with and extending between first and second end portions. The arcuate center portion has a concave shape relative to the anterior end portion. At least one of the first and second end portions is securely attached to the posterior end portion.

摘要翻译： 提供了一种用于治疗通过患病心脏瓣膜的血液流量反流的装置。 该装置包括环形支撑构件和至少一个后叶片支撑构件。 环形支撑构件具有在端部之间延伸的前端部分，后端部分和相对设置的第一和第二中间部分。 至少一个后小叶支撑构件牢固地连接到环形支撑构件，并且其尺寸被设计成延伸穿过后瓣膜小叶的自由边缘的一部分。 后小叶支撑构件包括与第一和第二端部一体地形成并且在第一和第二端部之间延伸的弓形中心部分。 弓形中心部分相对于前端部分具有凹形。 第一端部和第二端部中的至少一个牢固地附接到后端部。

公开(公告)号：US07914576B2

公开(公告)日：2011-03-29

申请号：US11800454

申请日：2007-05-04

申请人： Jose Luis Navia ,  Ji-Feng Chen

发明人： Jose Luis Navia ,  Ji-Feng Chen

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2466 ,  A61F2/91

摘要： An apparatus for repairing a cardiac valve includes an annuloplasty ring having an expandable support member with oppositely disposed proximal and distal end portions and a main body portion between the end portions. The proximal end portion includes a plurality of wing members extending from the main body portion. Each of the wing members includes at least one hook member for embedding into a cardiac wall and a valve annulus to secure the annuloplasty ring therein. The apparatus also includes an energy delivery mechanism for selectively contracting the annuloplasty ring to restrict the valve annulus and correct valvular insufficiency. The energy delivery mechanism includes a detachable electrical lead having distal and proximal end portions. The distal end portion has a securing member for operably attaching the distal end portion to a portion of the expandable support member. The proximal end portion is operably connected to an energy delivery source.

摘要翻译： 用于修复心脏瓣膜的装置包括瓣膜成形术环，其具有可扩张的支撑构件，其具有相对设置的近端部分和远端部分以及端部之间的主体部分。 近端部包括从主体部延伸的多个翼部件。 每个翼构件包括至少一个用于嵌入心壁的钩构件和瓣环，以将瓣环成形术环固定在其中。 该装置还包括能量递送机构，用于选择性地收缩瓣环成形术环以限制瓣膜环和矫正瓣膜功能不全。 能量输送机构包括具有远端和近端部分的可拆卸电引线。 远端部分具有用于将远端部分可操作地附接到可扩张支撑构件的一部分的固定构件。 近端部分可操作地连接到能量输送源。

公开(公告)号：US07488346B2

公开(公告)日：2009-02-10

申请号：US11037499

申请日：2005-01-18

申请人： Jose Luis Navia

发明人： Jose Luis Navia

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  Y10S623/904

摘要： A method and apparatus for replacing both the native mitral valve and the native aortic valve in a heart with a stentless bioprosthetic graft is provided. The bioprosthetic graft comprises a harvested homograft that includes a mitral valve portion and an aortic valve portion, and an extension portion made of a biocompatible material. The extension portion is sutured to the homograft and is for suturing to the left atrial wall of the heart to close an incision in the left atrial wall following implantation of the mitral valve portion and the aortic valve portion of the homograft.

摘要翻译： 提供了用无置换生物假体移植物替代心脏中的天然二尖瓣和天然主动脉瓣的方法和装置。 生物假体移植物包括收获的同种移植物，其包括二尖瓣部分和主动脉瓣部分，以及由生物相容性材料制成的延伸部分。 将延伸部分缝合到同种移植物，并用于缝合到心脏的左心房壁，以在植入二尖瓣部分和同种移植物的主动脉瓣部分之后闭合左心房壁中的切口。

公开(公告)号：US07004926B2

公开(公告)日：2006-02-28

申请号：US10938048

申请日：2004-09-10

申请人： Jose Luis Navia ,  Jose Antonio Navia ,  Jorge Luis Jordana

发明人： Jose Luis Navia ,  Jose Antonio Navia ,  Jorge Luis Jordana

IPC分类号： A61M37/00 ,  A61M29/00 ,  A61M1/14 ,  A61F2/06

CPC分类号： A61B17/12172 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12136 ,  A61B2017/1139 ,  A61F2/86 ,  A61M1/3613

摘要： An apparatus for automatically retroperfusing a coronary vein includes an intraluminal cannula having a main body portion extending between a proximal end portion and a distal end portion. The proximal end portion is for connecting to an artery outside of the pericardium to automatically supply oxygenated blood from the artery for retroperfusion. The main body portion and the distal end portion are insertable through a vein that is fluidly connected with the coronary vein and into the coronary vein. An expandable stent is attached to the distal end portion for expanding radially into engagement with the interior wall of the coronary vein to secure the distal end portion at a desired location within the coronary vein. Occluding structure for at least partially occluding the coronary vein is provided at the distal end to decrease the back-flow of blood into the right atrium during retroperfusion. The cannula includes passages that allow a limited amount of blood to bypass the occluding structure.

摘要翻译： 用于自动回灌冠状静脉的装置包括管腔内插管，其具有在近端部分和远端部分之间延伸的主体部分。 近端部分用于连接到心包外的动脉，以自动地从动脉供应氧合血液用于后路灌注。 主体部分和远端部分可通过与冠状静脉流体连接并进入冠状静脉的静脉插入。 可扩张支架附接到远端部分，用于径向扩张以与冠状静脉的内壁接合，以将远端部分固定在冠状静脉内的期望位置。 在远端提供用于至少部分阻塞冠状静脉的封闭结构，以减少后期灌注期间血液向右心房的逆流。 套管包括允许有限量的血液绕过闭塞结构的通道。

公开(公告)号：US09114035B2

公开(公告)日：2015-08-25

申请号：US11789827

申请日：2007-04-26

申请人： Carlos Oberti ,  Jose Luis Navia

发明人： Carlos Oberti ,  Jose Luis Navia

IPC分类号： A61F2/06 ,  A61F2/24 ,  A61F2/90 ,  A61F2/95 ,  A61F2/82 ,  A61N1/362

CPC分类号： A61F2/90 ,  A61F2/95 ,  A61F2002/821 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/003 ,  A61F2250/0067 ,  A61N1/362

摘要： An apparatus for treating cardiovascular diseases includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion between the end portions for positioning in a blood vessel. The proximal end portion of the expandable support member includes a plurality of wing members that extend from the main body portion. Each of the wing members is for engaging at least a portion of an antrum of a cardiac chamber surrounding the blood vessel. At least a portion of the expandable support member is treated with at least one therapeutic agent for eluting into the blood vessel, the cardiac chamber, and/or cardiac tissue. The expandable support member is made of wire-mesh, and at least a portion of the expandable support member may be made of a bioabsorbable material.

摘要翻译： 用于治疗心血管疾病的装置包括具有相对设置的近端部分和远端部分的可扩张支撑构件和位于端部之间的主体部分，用于定位在血管中。 可扩展支撑构件的近端部分包括从主体部分延伸的多个翼构件。 每个翼构件用于接合围绕血管的心室的窦的至少一部分。 至少一部分可膨胀支撑构件用至少一种用于洗脱到血管，心脏腔和/或心脏组织中的治疗剂进行治疗。 可膨胀支撑构件由金属丝网制成，并且可膨胀支撑构件的至少一部分可以由生物可吸收材料制成。

公开(公告)号：US08105375B2

公开(公告)日：2012-01-31

申请号：US12016168

申请日：2008-01-17

申请人： Jose Luis Navia ,  Ji-Feng Chen

发明人： Jose Luis Navia ,  Ji-Feng Chen

IPC分类号： A61F2/24

CPC分类号： A61F2/2433 ,  A61F2/0095 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2436 ,  A61F2002/9522 ,  A61F2220/0008 ,  A61F2230/0078 ,  A61F2250/0092 ,  A61L27/3625 ,  A61L27/3629 ,  A61L27/3687 ,  A61L27/3691 ,  Y10T29/49925

摘要： A method is provided for implanting a valve having at least one valve leaflet within the cardiovascular system of a subject. One step of the method includes preparing a substantially dehydrated bioprosthetic valve and then providing an expandable support member having oppositely disposed first and second ends and a main body portion extending between the ends. Next, the substantially dehydrated bioprosthetic valve is attached to the expandable support member so that the substantially dehydrated bioprosthetic valve is operably secured within the main body portion of the expandable support member. The expandable support member is then crimped into a compressed configuration and placed at a desired location within the cardiovascular system of the subject. Either before or after placement at the desired location, fluid or blood re-hydrates the substantially dehydrated bioprosthetic valve.

摘要翻译： 提供了一种用于在受试者的心血管系统内植入具有至少一个瓣膜小叶的瓣膜的方法。 该方法的一个步骤包括制备基本脱水的生物假肢瓣膜，然后提供具有相对设置的第一和第二端部的可扩张支撑构件以及在端部之间延伸的主体部分。 接下来，基本上脱水的生物假肢瓣膜连接到可膨胀支撑构件，使得基本脱水的生物假肢瓣膜可操作地固定在可扩张支撑构件的主体部分内。 然后将可膨胀的支撑构件卷曲成压缩构型，并将其放置在受试者的心血管系统内的期望位置。 在放置在所需位置之前或之后，流体或血液重新水合基本上脱水的生物假体瓣膜。

公开(公告)号：US20110153009A1

公开(公告)日：2011-06-23

申请号：US13040394

申请日：2011-03-04

申请人： Jose Luis Navia ,  Ji-Feng Chen

发明人： Jose Luis Navia ,  Ji-Feng Chen

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2466 ,  A61F2/91

摘要： An apparatus for repairing a cardiac valve includes an annuloplasty ring having an expandable support member with oppositely disposed proximal and distal end portions and a main body portion between the end portions. The proximal end portion includes a plurality of wing members extending from the main body portion. Each of the wing members includes at least one hook member for embedding into a cardiac wall and a valve annulus to secure the annuloplasty ring therein. The apparatus also includes an energy delivery mechanism for selectively contracting the annuloplasty ring to restrict the valve annulus and correct valvular insufficiency. The energy delivery mechanism includes a detachable electrical lead having distal and proximal end portions. The distal end portion has a securing member for operably attaching the distal end portion to a portion of the expandable support member. The proximal end portion is operably connected to an energy delivery source.

摘要翻译： 用于修复心脏瓣膜的装置包括瓣膜成形术环，其具有可扩张的支撑构件，其具有相对设置的近端部分和远端部分以及端部之间的主体部分。 近端部包括从主体部延伸的多个翼部件。 每个翼构件包括至少一个用于嵌入心壁的钩构件和瓣环，以将瓣环成形术环固定在其中。 该装置还包括能量递送机构，用于选择性地收缩瓣环成形术环以限制瓣膜环和矫正瓣膜功能不全。 能量输送机构包括具有远端和近端部分的可拆卸电引线。 远端部分具有用于将远端部分可操作地附接到可扩张支撑构件的一部分的固定构件。 近端部分可操作地连接到能量输送源。

公开(公告)号：US07927371B2

公开(公告)日：2011-04-19

申请号：US11586828

申请日：2006-10-26

申请人： Jose Luis Navia ,  Jose Antonio Navia ,  Ghassan Kassab

发明人： Jose Luis Navia ,  Jose Antonio Navia ,  Ghassan Kassab

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2466 ,  A61F2210/009 ,  A61F2250/0001 ,  A61F2250/0004

摘要： An apparatus for modifying the annulus of a cardiac valve to reduce regurgitation of blood flow through the cardiac valve includes a first annuloplasty ring having a first diameter and being disposed about a first aspect of the annulus of the cardiac valve. The apparatus also includes an elongate flexible body having proximal and distal end portions and being insertable into the first annuloplasty ring. The elongate flexible body has an adjustable mechanism for selectively adjusting the elongate flexible body from a first relaxed configuration to a second tensioned configuration. The first annuloplasty ring is adaptable to obtain a second smaller diameter and to cause the annulus of the cardiac valve to be modified and reduce regurgitation of blood flow through the cardiac valve when the elongate flexible body obtains the second tensioned configuration.

摘要翻译： 用于改变心脏瓣膜的环以减少通过心脏瓣膜的血流反流的装置包括具有第一直径的第一瓣环成形术环，并且围绕心脏瓣膜的环的第一方面设置。 该装置还包括具有近端部分和远端部分并且可插入第一瓣环成形术环的细长柔性体。 细长柔性体具有可调节机构，用于将细长柔性体从第一松弛构型选择性地调节到第二张紧构型。 第一瓣环成形术环适用于获得第二较小的直径，并且当细长的柔性体获得第二张紧构造时，使得心脏瓣膜的环被修改并且减少通过心脏瓣膜的血流的反流。