公开(公告)号：US20220254448A1

公开(公告)日：2022-08-11

申请号：US17629766

申请日：2020-07-24

Applicant: Franz-Josef MÜLLER ,  Bernhard M. SCHULDT ,  The Scripps Research Institute ,  Aspen Neuroscience, Inc.

Inventor： Jeanne F. LORING ,  Franz-Josef MÜLLER ,  Roy WILLIAMS ,  Bernhard M. SCHULDT ,  Andres BRATT-LEAL

IPC: G16B25/10 ,  G16B40/20 ,  C12N5/0793 ,  A61K35/30

Abstract: Provided herein are, inter alia, methods of assaying neuronal progenitor cell populations derived from iPSCs, thereby providing for a user friendly molecular diagnostic tool for neuronal cell types, including dopaminergic neurons. The methods provided are valuable for the efficient and precise characterization of identity and functionality of iPSC-derived dopaminergic neurons prior to their clinical application such as the treatment of Parkinson's disease or Multiple Sclerosis.

公开(公告)号：US20130209723A1

公开(公告)日：2013-08-15

申请号：US13805081

申请日：2011-06-24

Applicant: Franz Josef Müller ,  Peter Werner ,  Peter Stracke

Inventor： Franz Josef Müller ,  Peter Werner ,  Peter Stracke

IPC: E04B1/14

CPC classification number: E04B1/14 ,  B29C44/06 ,  B29C44/1214 ,  B29C44/1228 ,  B29C44/326 ,  B29C70/68 ,  B29K2311/10 ,  B32B5/18 ,  B32B5/20 ,  B32B5/22 ,  B32B5/245 ,  B32B37/1207 ,  B32B38/06 ,  B32B2037/1269 ,  B32B2038/0084 ,  B32B2250/40 ,  B32B2260/021 ,  B32B2260/023 ,  B32B2260/046 ,  B32B2262/062 ,  B32B2262/065 ,  B32B2262/08 ,  B32B2262/14 ,  B32B2266/0285 ,  B32B2305/022 ,  B32B2305/07 ,  B32B2305/20 ,  B32B2305/34 ,  B32B2307/546 ,  B32B2307/718 ,  B32B2309/02 ,  B32B2309/04 ,  B32B2309/10 ,  B32B2419/00 ,  B32B2607/00 ,  C08J5/045 ,  C08J5/24 ,  C08J9/0085 ,  C08J2361/06 ,  E04C2/22 ,  E04C2/243 ,  Y10T428/23914

Abstract: The invention relates to a method for producing sandwich construction elements for substantially load-bearing and self-supporting building parts. In order to produce a sandwich element which is suitable for self-supporting and substantially load-bearing building parts, since it ensures the necessary transmission of the compressive, tensile and shear forces between the cover layer and core layer and meets the increased fire-protection requirements, the production method proposed contains the following steps: a) producing at least one layer of a mechanically bonded fiber nonwoven which is impregnated with a binder based on at least one heat-curable resin system, and is itself based on naturally occurring raw materials, in particular hemp, flax, jute, sisal, kenaf, cotton and wool and/or mixtures thereof, b) curing the heat-curable resin system in order to produce at least one hardened layer of the fiber nonwoven, wherein, before and/or during the curing operation, a surface structure is applied to at least part of the layer of the fiber nonwoven and/or at least one further binder based on at least one heat-curable resin system is applied to at least part of the surface of the hardened layer of the fiber nonwoven, and fixed thermally, c) bringing a heat-foamable or heat-foamed phenol resin into contact with that surface of at least one hardened layer of the fiber nonwoven which has been modified according to step b), d) possibly annealing, at temperatures ranging from 40 to 80° C., the composite produced in a) to c), and e) curing the further binder based on at least one heat-curable resin system, and possibly applied in b), at a temperature ranging from 150 to 200° C., possibly under elevated pressure.

Abstract translation: 本发明涉及一种用于生产用于大体上承载和自支撑建筑部件的夹层结构件的方法。 为了生产适合于自支撑和基本承重建筑部件的夹层元件，因为它确保了覆盖层和芯层之间的压缩，拉伸和剪切力的必要传递，并满足增加的防火保护 要求，提出的生产方法包括以下步骤：a）生产至少一层机械粘合的纤维非织造材料，其基于至少一种热固性树脂体系浸渍有粘合剂，并且本身基于天然存在的原料 特别是大麻，亚麻，黄麻，剑麻，洋麻，棉和羊毛和/或其混合物，b）固化可热固化的树脂体系，以便生产至少一个纤维无纺布的硬化层，其中，在和/ 或者在固化操作期间，基于至少一种热固化树脂体系，至少部分纤维非织造材料层和/或至少一种其它粘合剂施加表面结构 施加到纤维非织造材的硬化层的至少一部分表面上并热固化，c）使可发泡或热发泡的酚醛树脂与纤维非织造材料的至少一个硬化层的表面接触， 已经根据步骤b）进行了改性，d）在40至80℃的温度下可能退火，在a）至c）中制备的复合材料，以及e）基于至少一种可热固化的 树脂体系，并且可能在b）中，在150至200℃的温度下，可能在升高的压力下。

公开(公告)号：US20100285314A1

公开(公告)日：2010-11-11

申请号：US11631802

申请日：2005-07-14

Applicant: Franz-Josef Müller

Inventor： Franz-Josef Müller

IPC: D02G3/22 ,  B29C43/02

CPC classification number: D04H1/407 ,  D04H1/60 ,  Y10T428/24994 ,  Y10T428/249952 ,  Y10T428/2964 ,  Y10T428/2971

Abstract: The invention relates to thermoset-bound fiber moldings produced from fiber material based on natural and/or synthetic fibers and bound by means of a thermoset binder. To produce thermoset-bound fiber moldings which combine the good mechanical, acoustical and fire properties of phenolic-bound fiber moldings with an ideally complete absence of any odor due to phenolic resin, at least one adsorbent is embedded in the surface and/or in the interior of the fiber molding during the operation of pre- and/or end-curing the thermosetting binder.

Abstract translation: 本发明涉及由基于天然和/或合成纤维并通过热固性粘合剂结合的纤维材料制成的热固性纤维模制品。 为了生产热固性纤维模制品，其结合酚键合纤维模制品的良好机械，声学和火焰性能，理想地完全不存在由酚醛树脂引起的任何气味，至少一种吸附剂嵌入在表面和/或 在预热和/或最终固化热固性粘合剂的操作期间纤维成型的内部。

公开(公告)号：US06866451B2

公开(公告)日：2005-03-15

申请号：US10398571

申请日：2001-09-04

Applicant: Jan Braasch ,  Josef Müller ,  Martin Seichter

Inventor： Jan Braasch ,  Josef Müller ,  Martin Seichter

IPC: G01K7/25 ,  B23Q17/00 ,  G01B7/16 ,  G05B19/404 ,  B23C9/00 ,  B23Q15/18

CPC classification number: G01B7/20 ,  G05B19/404 ,  G05B2219/37274 ,  Y10S33/19 ,  Y10T408/16 ,  Y10T409/303976 ,  Y10T409/304648 ,  Y10T409/306832 ,  Y10T409/307224 ,  Y10T409/308008 ,  Y10T409/309744

Abstract: A device for detecting thermally caused linear expansions of a machine element, wherein the device includes a temperature sensor placed along an expansion direction. The temperature sensor includes a first metallic conductor having an electrical resistance that is proportional to an average temperature of an area to be monitored and a plurality of trimmer tracks in the form of further metallic conductors placed next to the first metallic conductor. The temperature sensor further includes electrical connections selectively interconnecting the plurality of trimmer tracks with the first metallic conductor and wherein the plurality of the trimmer tracks have an effective electrical resistance that is proportional to the average temperature of the area to be monitored.

Abstract translation: 一种用于检测机械元件的热引起的线性膨胀的装置，其中所述装置包括沿着膨胀方向放置的温度传感器。 温度传感器包括具有与待监测区域的平均温度成比例的电阻的第一金属导体和放置在靠近第一金属导体的另外的金属导体形式的多个修剪器轨道。 温度传感器还包括选择性地将多个修剪器轨道与第一金属导体互连的电连接，并且其中多个修剪器轨道具有与被监视区域的平均温度成正比的有效电阻。

公开(公告)号：US06481968B1

公开(公告)日：2002-11-19

申请号：US09936009

申请日：2001-09-06

Applicant: Manfred Fischer ,  Josef Müller

Inventor： Manfred Fischer ,  Josef Müller

IPC: B64C2704

CPC classification number: B64C27/14

Abstract: The invention is based on a helicopter having the following features: one rotor head (1) is non-rotatably connected with a rotor mast (3) which is rotatably mounted in a housing (5) of a transmission (6); one or more driving mechanisms actuate the rotor mast (3) via the transmission (6) with a summarizing gear (11) fastened on said rotor mast (3), one swash plate (17) is supported by its stationary part (18) via a first fork in a non-rotatable but axially displaceable manner and tiltably in all directions relative to this axis of said rotor mast (3); a rotatable part (19) of said swash plate (17) is rotatably supported against said stationary part (18) of said swash plate (17) via axial and radial bearings (23) and non-rotatably hinged on said rotor head (1) by means of a second fork. It is proposed that said rotor mast (3) grows funnel-shaped wider toward the housing (5) of the transmission (6), said summarizing gear (11) being flanged via a hollow stub shaft (12) on the widened end of the rotor mast (3) and the stub shaft (12) and the rotor mast (3) are rotatably supported together upon a large diameter in the housing (5). The support of the rotor mast (3) is thereby improved.

Abstract translation: 本发明基于具有以下特征的直升机：一个转子头（1）与可转动地安装在变速器（6）的壳体（5）中的转子杆（3）不可旋转地连接;一个或多个 驱动机构通过变速器（6）通过固定在所述转子桅杆（3）上的总成齿轮（11）致动转子桅杆（3），一个斜盘（17）由其第一叉 以相对于所述转子桅杆（3）的该轴线的所有方向可倾斜地不可旋转但可轴向移动;所述旋转斜盘（17）的可旋转部分（19）可旋转地支撑在所述固定部分 所述斜盘（17）经由轴向和径向轴承（23），并且通过第二叉不可旋转地铰接在所述转子头部（1）上。 提出所述转子桅杆（3）朝向变速器（6）的壳体（5）形成较大的漏斗形，所述总结齿轮（11）通过中空短轴（12）在所述变速器 转子桅杆（3）和短轴（12）和转子桅杆（3）在壳体（5）中以大直径可旋转地支撑在一起。 从而改进了转子桅杆（3）的支撑。

公开(公告)号：US08110153B2

公开(公告)日：2012-02-07

申请号：US11856097

申请日：2007-09-17

Applicant: Hans-Günter Faust ,  Jörg Gutowski ,  Friedrich-Wilhelm Kaiser ,  Hermann Josef Müller ,  Gottfried Wilhelm Haesemann

Inventor： Hans-Günter Faust ,  Jörg Gutowski ,  Friedrich-Wilhelm Kaiser ,  Hermann Josef Müller ,  Gottfried Wilhelm Haesemann

IPC: B01D50/00

CPC classification number: F01N13/1838 ,  F01N3/28 ,  F01N2260/18 ,  F01N2450/22 ,  F01N2470/20 ,  Y02A50/2322 ,  Y10T29/49398

Abstract: A housing for an exhaust gas treatment component includes a casing having a first thickness and a first length and at least one sleeve having a second thickness and a second length. The at least one sleeve is at least partially in contact with the outside of the casing and is connected thereto. The second length of the at least one sleeve is shorter than the first length of the casing. An exhaust gas treatment component, an exhaust gas system and a motor vehicle are also provided.

Abstract translation: 一种用于废气处理部件的壳体包括具有第一厚度和第一长度的壳体以及具有第二厚度和第二长度的至少一个套筒。 所述至少一个套筒至少部分地与所述壳体的外部接触并与其连接。 所述至少一个套筒的所述第二长度比所述壳体的所述第一长度短。 还提供废气处理部件，排气系统和机动车辆。

公开(公告)号：US08012575B2

公开(公告)日：2011-09-06

申请号：US11631802

申请日：2005-07-14

Applicant: Franz-Josef Müller

Inventor： Franz-Josef Müller

IPC: B32B13/02

CPC classification number: D04H1/407 ,  D04H1/60 ,  Y10T428/24994 ,  Y10T428/249952 ,  Y10T428/2964 ,  Y10T428/2971

Abstract: The invention relates to thermoset-bound fiber moldings produced from fiber material based on natural and/or synthetic fibers and bound by means of a thermoset binder. To produce thermoset-bound fiber moldings which combine the good mechanical, acoustical and fire properties of phenolic-bound fiber moldings with an ideally complete absence of any odor due to phenolic resin, at least one adsorbent is embedded in the surface and/or in the interior of the fiber molding during the operation of pre- and/or end-curing the thermosetting binder.

Abstract translation: 本发明涉及由基于天然和/或合成纤维并通过热固性粘合剂结合的纤维材料制成的热固性纤维模制品。 为了生产热固性纤维模制品，其结合酚键合纤维模制品的良好机械，声学和火焰性能，理想地完全不存在由酚醛树脂引起的任何气味，至少一种吸附剂嵌入表面和/或 在预热和/或最终固化热固性粘合剂的操作期间纤维成型的内部。

公开(公告)号：US07964147B2

公开(公告)日：2011-06-21

申请号：US11474861

申请日：2006-06-23

Applicant: Jochen Schulat ,  Jörg Scherer ,  Jürgen Rasch-Menges ,  Josef Müller ,  Paul Jansen

Inventor： Jochen Schulat ,  Jörg Scherer ,  Jürgen Rasch-Menges ,  Josef Müller ,  Paul Jansen

IPC: G01N33/00

CPC classification number: G01N33/48757

Abstract: The invention relates to a hand-held analytical device for analyzing a sample, in particular a biological fluid, for a medically significant component, comprising a housing comprising a loading opening for receiving a replaceable cartridge having multiple chambers that may contain analytical consumables, in particular test strips, and each chamber comprising an opening on at least one face of the cartridge and each opening may be sealed by a sealing foil, a removal facility for removing one of the analytical consumables from the cartridge. The removal facility can be used to remove one of the consumables from one of the chambers of the cartridge, in the process of which the opening sealed by the sealing foil is opened. A drive allows the cartridge to be moved in order to position one chamber in a removal position in which a consumable can be removed from the chamber by the removal facility. The invention provides for the hand-held analytical device to comprise a testing facility that can generate a signal containing information regarding whether the opening of one of the chambers is sealed by sealing foil.

Abstract translation: 本发明涉及一种用于分析用于医疗重要部件的样品，特别是生物流体的手持式分析装置，其包括壳体，该壳体包括用于接收具有多个可能容纳分析消耗品的室的可替换筒的装载开口 测试条，并且每个室包括在该盒的至少一个表面上的开口和每个开口可以由密封箔密封，用于从盒中去除分析消耗品之一的去除设备。 移除设备可以用于从盒的一个室中移除一个消耗品，在该过程中，由密封箔密封的开口打开。 驱动器允许盒移动以便将一个室定位在去除位置，在该位置中消耗品可以通过移除设施从该室移除。 本发明提供了一种手持分析装置，其包括测试设备，该测试设备可以产生包含关于其中一个室的开口是否通过密封箔密封的信息的信号。

公开(公告)号：US20110118130A1

公开(公告)日：2011-05-19

申请号：US12806779

申请日：2010-08-20

Applicant: Jeanne F. Loring ,  Franz-Josef Müller

Inventor： Jeanne F. Loring ,  Franz-Josef Müller

IPC: C40B30/00 ,  C12Q1/68 ,  G06F19/00 ,  G06F7/60 ,  G06N3/00

CPC classification number: G06F19/24 ,  G06F19/20 ,  G06F19/28 ,  G06N99/005

Abstract: Disclosed are compositions and methods for classifying stem cells. The disclosure provides a way to define cells using a computational analysis.

Abstract translation: 公开了用于分类干细胞的组合物和方法。 本公开提供了使用计算分析来定义单元的方法。

公开(公告)号：US07736717B2

公开(公告)日：2010-06-15

申请号：US11405206

申请日：2006-04-17

Applicant: Hermann Josef Müller

Inventor： Hermann Josef Müller

IPC: B32B3/12 ,  B01D50/00

CPC classification number: F01N3/2875 ,  F01N3/0222 ,  F01N3/281 ,  F01N2330/02 ,  F01N2330/30 ,  Y02T10/20 ,  Y10T428/24149

Abstract: A honeycomb body includes a honeycomb structure through which a fluid can flow and which is disposed in a tubular casing that is substantially gas-impermeable in a radial direction. The tubular casing includes at least one inner tubular casing part and at least one outer tubular casing part, in which at least the outer tubular casing part has cutouts at least in a subregion. The tubular casing has a reduced weight as compared to standard tubular casings, yet nevertheless has the same mechanical stability and gas-tightness. It is also possible to form the tubular casing with thermal expansion properties which are adapted to a subsequent use.

Abstract translation: 蜂窝体包括蜂窝结构，流体可以流过蜂窝结构，并且设置在径向基本上不透气的管状壳体中。 管状壳体包括至少一个内部管状壳体部分和至少一个外部管状壳体部分，其中至少外部管状壳体部分至少在一个子区域中具有切口。 管状套管与标准管状肠衣相比具有减轻的重量，但仍具有相同的机械稳定性和气密性。 还可以形成具有适于随后使用的热膨胀特性的管状套管。