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公开(公告)号：US3574985A
公开(公告)日：1971-04-13
申请号：US3574985D
申请日：1969-02-28
申请人： JOSEPH A GARCIA , ROY C GARCIA , WILLIAM C PIERCE
发明人： PIERCE WILLIAM C
CPC分类号： E04D3/3601 , E04D3/366 , E04D13/1625 , E04D2003/3617
摘要： A horizontal beam of inverted generally T-shpaed vertical cross section supports edge portions of generally horizontal roof panels on transversely oppositely depending base flanges of said beam with a beam central web portion projecting upwardly between said panel edge portions, preferably in the form of transversely spaced vertical webs. Water proof upper layers of shape selfsustaining material are portioned over the panel upper surfaces and have edge portions which project upwardly from the panel edge portions and terminate spaced upwardly from said panel edge portions. An inverted U-shaped cap is positioned over the beam webs and has downwardly projecting leg portions transversely outwardly of the edge portions of the panel upper layers, said leg portions terminating downwardly overlying said panel upper layers. Transversely spaced webs project downwardly from the cap internally thereof and hook engage the beam webs retaining the cap and beam in assembly, with angled guides preferably being formed on the cap for guiding the beam webs into such assembly. Thus, the upwardly projecting edge portions of the panel upper layers provide water barriers internally of the cap for preventing water from flowing transversely into the assembly and downwardly along the inner edges of the panels.
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公开(公告)号：US08725470B1
公开(公告)日：2014-05-13
申请号：US13109954
申请日：2011-05-17
CPC分类号： G06F17/5095 , G06F17/5009 , G06F17/5018 , G06F2217/16
摘要： A method and associated system for multi-disciplinary optimization of various parameters associated with a space vehicle that experiences aerocapture and atmospheric entry in a specified atmosphere. In one embodiment, simultaneous maximization of a ratio of landed payload to vehicle atmospheric entry mass, maximization of fluid flow distance before flow separation from vehicle, and minimization of heat transfer to the vehicle are performed with respect to vehicle surface geometric parameters, and aerostructure and aerothermal vehicle response for the vehicle moving along a specified trajectory. A Pareto Optimal set of superior performance parameters is identified.
摘要翻译： 一种用于与特定气氛中经历气蚀和大气进入的空间车辆相关的各种参数的多学科优化的方法和相关系统。 在一个实施例中，相对于车辆表面几何参数，航空结构和车辆空中结构以及相对于车辆大气进入质量的比例，同时最大化着陆有效载荷与车辆大气进入质量之间的最大化，流动与车辆分离之前的流体流动距离的最大化以及对车辆的热传递的最小化 车辆沿指定轨迹行驶的空气热响应。 识别出优秀性能参数的帕累托最优集。
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公开(公告)号：US5686264A
公开(公告)日：1997-11-11
申请号：US346613
申请日：1994-11-29
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/16 , C07K14/47 , C07K16/18 , C12N15/12 , C12N15/48 , C12P21/08 , G01N33/53 , C12P21/02 , C12N5/10 , C12N15/86
CPC分类号： C07K14/005 , C07K14/4702 , C07K16/18 , G01N33/5308 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2740/16322 , Y10S435/974 , Y10S930/221
摘要： Transdominant HIV tat substitution and truncated gene mutants of 72 amino acid residues or less are disclosed. The mutated genes encode mutant Tat proteins which are capable of inhibiting the expression of the HIV-1 virus in the presence of an equimolar concentration of the wild type Tat protein in vitro. Therapeutic agents which include fused protein forms of the mutant proteins are also disclosed, as well as methods of preparing and using the therapeutic agents in the treatment of HIV infection and HIV-related injections in an animal. Recombinant vectors which express the mutant HIV Tat proteins described are also disclosed, as well as cell lines which product high yields of the mutant HIV.
摘要翻译： 公开了72个氨基酸残基或以下的显性HIV tat取代和截短基因突变体。 突变的基因编码突变的Tat蛋白，其能够在体外在等摩尔浓度的野生型Tat蛋白存在下抑制HIV-1病毒的表达。 还公开了包括突变蛋白质的融合蛋白形式的治疗剂，以及制备和使用治疗剂在动物中治疗HIV感染和HIV相关注射的方法。 还公开了表达所描述的突变型HIV Tat蛋白的重组载体，以及产生突变型HIV高产量的细胞系。
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公开(公告)号：US5597895A
公开(公告)日：1997-01-28
申请号：US910867
申请日：1992-07-02
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/16 , C07K14/47 , C07K16/18 , C12N15/12 , C12N15/48 , C12P21/08 , G01N33/53 , C07K14/15 , C07K14/155
CPC分类号： C07K14/005 , C07K14/4702 , C07K16/18 , G01N33/5308 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2740/16322 , Y10S435/974 , Y10S930/221
摘要： Transdominant HIV tat substitution and truncated gene mutants of 72 amino acid residues or less are disclosed. The mutated genes encode mutant Tat proteins which are capable of inhibiting the expression of the HIV-1 virus in the presence of an equimolar concentration of the wild type Tat protein in vitro. Therapeutic agents which include fused protein forms of the mutant proteins are also disclosed, as well as methods of preparing and using the therapeutic agents in the treatment of HIV infection and HIV-related injections in an animal. Recombinant vectors which express the mutant HIV Tat proteins described are also disclosed, as well as cell lines which product high yields of the mutant HIV.
摘要翻译： 公开了72个氨基酸残基或以下的显性HIV tat取代和截短基因突变体。 突变的基因编码突变的Tat蛋白，其能够在体外在等摩尔浓度的野生型Tat蛋白存在下抑制HIV-1病毒的表达。 还公开了包括突变蛋白质的融合蛋白形式的治疗剂，以及制备和使用治疗剂在动物中治疗HIV感染和HIV相关注射的方法。 还公开了表达所描述的突变型HIV Tat蛋白的重组载体，以及产生突变型HIV高产量的细胞系。
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5.发明授权Wall panel construction and assembly including improved edge and bottom sealing 失效墙板结构和组装，包括改进的边缘和底部密封
公开(公告)号：US3603049A
公开(公告)日：1971-09-07
申请号：US3603049D
申请日：1969-08-18
申请人： WILLIAM C PIERCE , JOSEPH A GARCIA , ROY C GARCIA
发明人： PIERCE WILLIAM C
CPC分类号： E04B1/6125 , E04B2/78
摘要： Upright wall panels have vertical side edges thereof aligned and continuously vertically extending side edge opening recesses, semicircular in horizontal cross section, aligned to form an assembled substantially circular recess between assembled side edges, each recess preferably having continuously vertically extending serrations formed therein and spaced horizontally therearound. The panel side edges horizontally telescope a circular cross section, vertical tie bar received within the assembled recesses, the tie bar having a resilient material sleeve the entire vertical extent of said panel side edges horizontally compressed over and inwardly between the recess serrations. At the same time, opposite face surface flanges at one of the panel side edges telescope and horizontally abut similar face surface flanges of the other panel side edge. Bottom edges of the assembled panels rest downwardly on a baseplate having an upwardly extending, semicircular projection received upwardly into downwardly opening, similar serration formed recesses at the panel bottom edges and a resilient material strip covering the baseplate is compressed over the baseplate projection over and between the serrations of the panel bottom edge recesses. Also, parts of the panel bottom edges at opposite face surfaces thereof downwardly compress the resilient material strip against the baseplate and the resilient material strip extends and is compressed beneath the under surface of the baseplate and a horizontal supporting surface.
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公开(公告)号：US08337499B2
公开(公告)日：2012-12-25
申请号：US11980208
申请日：2007-10-30
IPC分类号： A61B17/00
CPC分类号： A61B17/17 , A61B17/16 , A61B17/1622 , A61B17/1624 , A61C1/18
摘要： The present invention provides surgical drilling devices and methods. An exemplary surgical drilling device in accordance with the present invention comprises a housing, a retractable guide tube assembly, and a flexible cable drill. The retractable guide tube assembly comprises an arcuate guide tube slidingly positioned in a first arcuate channel of the housing. The arcuate guide tube is operatively connected to an actuating rod slidingly positioned in a second channel of the housing wherein the actuating rod controllably advances and retracts the arcuate guide tube. The flexible cable drill comprises a first portion slidingly positioned in the arcuate guide tube and a second portion slidingly positioned in a third channel of the housing.
摘要翻译： 本发明提供了外科手术钻孔装置和方法。 根据本发明的示例性外科手术钻孔装置包括壳体，可伸缩导管组件和柔性电缆钻头。 可伸缩导管组件包括滑动定位在壳体的第一弧形通道中的弓形引导管。 弧形引导管可操作地连接到滑动地定位在壳体的第二通道中的致动杆，其中致动杆可控制地前进和缩回弓形引导管。 柔性电缆钻头包括滑动地定位在弧形引导管中的第一部分和滑动定位在壳体的第三通道中的第二部分。
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公开(公告)号：US07431242B1
公开(公告)日：2008-10-07
申请号：US11265324
申请日：2005-11-01
IPC分类号： B64G1/62
摘要： A convex shell structure for enhanced aerodynamic performance and/or reduced heat transfer requirements for a space vehicle that re-enters an atmosphere. The structure has a fore-body, an aft-body, a longitudinal axis and a transverse cross sectional shape, projected on a plane containing the longitudinal axis, that includes: first and second linear segments, smoothly joined at a first end of each the first and second linear segments to an end of a third linear segment by respective first and second curvilinear segments; and a fourth linear segment, joined to a second end of each of the first and second segments by curvilinear segments, including first and second ellipses having unequal ellipse parameters. The cross sectional shape is non-symmetric about the longitudinal axis. The fourth linear segment can be replaced by a sum of one or more polynomials, trigonometric functions or other functions satisfying certain constraints.
摘要翻译： 用于增强空气动力性能的凸壳结构和/或重新进入气氛的空间车辆的传热要求降低。 该结构具有突出在包含纵向轴线的平面上的前体，后体，纵向轴线和横截面形状，其包括：第一和第二线性段，在每个的第一端处平滑地接合 第一和第二线性段通过相应的第一和第二曲线段到达第三线性段的端部; 以及第四线性段，其通过曲线段连接到每个第一和第二段的第二端，包括具有不等椭圆参数的第一和第二椭圆。 横截面形状关于纵向轴线是不对称的。 第四线性段可以由一个或多个多项式，三角函数或满足某些约束的其他函数的和代替。
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