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公开(公告)号：US08455656B2
公开(公告)日：2013-06-04
申请号：US12380493
申请日：2009-02-26
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster , Xialing Guo , Sougato Boral
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster , Xialing Guo , Sougato Boral
IPC分类号： A61K31/40 , A61F9/007 , C07D213/00
CPC分类号： C07D405/04 , A61K9/0051 , A61K9/5031 , A61K31/397 , A61K31/404 , A61K31/41 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D213/82 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/06
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
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公开(公告)号：US08383825B2
公开(公告)日：2013-02-26
申请号：US13178277
申请日：2011-07-07
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
IPC分类号： C07D211/72 , A61K31/44 , A61K31/50
CPC分类号： C07D213/82 , A61K9/0051 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/34 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/06 , Y02A50/401
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
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公开(公告)号：US07749530B2
公开(公告)日：2010-07-06
申请号：US12317469
申请日：2008-12-23
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Wendy M. Blanda
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Wendy M. Blanda
IPC分类号： A61K31/404
CPC分类号： A61K9/204 , A61K9/0051 , A61K31/404 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D495/04 , C07D513/04 , C40B40/04 , Y10S514/954
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。
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公开(公告)号：US07692005B2
公开(公告)日：2010-04-06
申请号：US11456926
申请日：2006-07-12
申请人： Julie A. Wurster , Edward H. Wang , Richard C. Yee
发明人： Julie A. Wurster , Edward H. Wang , Richard C. Yee
IPC分类号： C07D413/14 , C07D403/14
CPC分类号： C07D495/04 , C07D209/34 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04 , C40B40/04
摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译： 本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。
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公开(公告)号：US20090208557A1
公开(公告)日：2009-08-20
申请号：US12317469
申请日：2008-12-23
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Wendy M. Blanda
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Wendy M. Blanda
IPC分类号： A61F2/00 , A61K31/403 , A61K31/4965 , A61K31/4427 , A61K31/53
CPC分类号： A61K9/204 , A61K9/0051 , A61K31/404 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D495/04 , C07D513/04 , C40B40/04 , Y10S514/954
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
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公开(公告)号：US07531665B2
公开(公告)日：2009-05-12
申请号：US10829139
申请日：2004-04-20
申请人： Steven W. Andrews , Michael E. Garst , Xialing Guo , Jonathan J. Hebert , Thomas Malone , Julie A. Wurster , Clarence Eugene Hull, III
发明人： Steven W. Andrews , Michael E. Garst , Xialing Guo , Jonathan J. Hebert , Thomas Malone , Julie A. Wurster , Clarence Eugene Hull, III
IPC分类号： C07D401/14
CPC分类号： C07D403/06 , C07D209/34 , C07D405/04
摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译： 本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。
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7.发明授权3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors 失效3-（芳基氨基）亚甲基-1,3-二氢-2H-吲哚-2-酮作为激酶抑制剂公开(公告)号：US06765012B2
公开(公告)日：2004-07-20
申请号：US10256879
申请日：2002-09-27
IPC分类号： A61K31435
CPC分类号： C07D295/088 , A61K31/404 , C07D209/34 , C07D295/135 , C07D401/10 , C07D403/12
摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译： 本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。
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公开(公告)号：US20120207810A1
公开(公告)日：2012-08-16
申请号：US13396946
申请日：2012-02-15
申请人： Lon T. SPADA , Jane Guo SHIAH , Patrick HUGHES , Thomas C. MALONE , Gerald W. DEVRIES , Jeffrey L. EDELMAN , Julie A. WURSTER
发明人： Lon T. SPADA , Jane Guo SHIAH , Patrick HUGHES , Thomas C. MALONE , Gerald W. DEVRIES , Jeffrey L. EDELMAN , Julie A. WURSTER
IPC分类号： A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/443 , A61K31/695 , A61K31/497 , A61K31/541 , A61K31/4545 , A61P27/06 , A61P27/02 , A61K9/00 , A61K31/5377
CPC分类号： C07D213/82 , A61K9/0051 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/34 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/06 , Y02A50/401
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。
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公开(公告)号：US07439371B2
公开(公告)日：2008-10-21
申请号：US11456630
申请日：2006-07-11
申请人： Julie A. Wurster , Richard C. Yee
发明人： Julie A. Wurster , Richard C. Yee
IPC分类号： C07D403/10 , C07D209/34
CPC分类号： C07D209/34 , C07D403/12
摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译： 本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。
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公开(公告)号：US08558002B2
公开(公告)日：2013-10-15
申请号：US13277842
申请日：2011-10-20
申请人： Sougato Boral , Shimiao Wang , Julie A. Wurster
发明人： Sougato Boral , Shimiao Wang , Julie A. Wurster
IPC分类号： C07D241/00 , C07D211/72 , A61K31/497 , A61K31/44
CPC分类号： C07D417/06 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D213/82 , C07D241/24 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/12
摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译： 本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。
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