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公开(公告)号：US08778411B2
公开(公告)日：2014-07-15
申请号：US12993293
申请日：2009-05-20
申请人： Jin Woo Cheon , Jung Tak Jang
发明人： Jin Woo Cheon , Jung Tak Jang
CPC分类号： C09K5/14 , A61K9/5115 , A61K41/0052 , A61N1/406
摘要： The present invention relates to a heat-generating composition, comprising a hetero-structure nanomaterial which comprises (a) a first material comprising at least one component selected from the group consisting of a metal, a metal chalcogen, a metal pnicogen, an alloy and a multi-component hybrid structure thereof; and (b) a second material comprising at least one component selected from the group consisting of metal, metal chalcogen, metal pnicogen, alloy and the multi-component hybrid structure thereof; wherein the first material is enclosed in the second material; wherein at least one of the first material and the second material comprise a magnetic material. The specific loss power of the present nanomaterial is much higher than that of conventional nanomaterials (e.g., 40-fold higher than commercially accessible Feridex) and may be controlled by changing compositions or ratios of the first material and/or the second material. The heat-generating nanomaterial of the present invention may be used in a variety of application fields, for example cancer hyperthermia.
摘要翻译： 本发明涉及一种发热组合物，其包含异质结构纳米材料，其包含（a）第一材料，其包含选自金属，金属硫族元素，金属原子，合金和 其多组分杂化结构; 和（b）包含选自金属，金属硫属元素，金属致癌剂，合金及其多组分混合结构中的至少一种成分的第二材料; 其中所述第一材料被封闭在所述第二材料中; 其中所述第一材料和所述第二材料中的至少一个包括磁性材料。 本纳米材料的特定损耗功率远高于常规纳米材料（例如，比商业上可接受的Feridex高40倍），并且可以通过改变第一材料和/或第二材料的组成或比例来控制。 本发明的发热纳米材料可以用于各种应用领域，例如癌症高热。
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2.发明申请Methods for Controlling Heat Generation of Magnetic Nanoparticles and Heat Generating Nanomaterials 审中-公开控制磁性纳米颗粒和发热纳米材料发热的方法公开(公告)号：US20110135729A1
公开(公告)日：2011-06-09
申请号：US12993329
申请日：2009-05-20
申请人： Jin Woo Cheon , Jung Tak Jang
发明人： Jin Woo Cheon , Jung Tak Jang
CPC分类号： A61K41/0052 , A61K9/5094
摘要： The present invention relates to a method for controlling heat generation of a magnetic nanomaterial, comprising the steps of: (a) mixing (i) a nanomaterial precursor comprising a metal precursor material and a predetermined amount of a zinc precursor with (ii) a reaction solvent; and (b) preparing a zinc-containing magnetic nanomaterial from the mixture of step (a) comprising a zinc doped metal oxide nanomaterial matrix; and wherein a specific loss power of the zinc-containing magnetic nanomaterial is varied depending an amount of zinc to be doped, whereby the heat generation of the magnetic nanomaterial is controlled. In addition, the present invention relates to a heat-generating nanoparticle and a composition for hyperthermia. The present invention suggests a novel approach to improve a heat generation of a magnetic nanomaterial. According to the present invention, the specific loss power can be controlled by changing a zinc-content to be introduced into nanomaterials and therefore a composition for hyperthermia showing controlled heat generation potential can be successfully provided.
摘要翻译： 本发明涉及一种用于控制磁性纳米材料的发热的方法，包括以下步骤：（a）将（i）包含金属前体材料和预定量的锌前体的纳米材料前体与（ii）反应 溶剂; 和（b）从包含锌掺杂金属氧化物纳米材料基质的步骤（a）的混合物制备含锌磁性纳米材料; 并且其中所述含锌磁性纳米材料的特定损耗功率随着待掺杂的锌的量而变化，由此控制所述磁性纳米材料的发热。 另外，本发明涉及发热性纳米粒子和热疗用组合物。 本发明提出了改进磁性纳米材料的发热的新方法。 根据本发明，可以通过改变要引入纳米材料的锌含量来控制比损失功率，因此可以成功地提供显示受控制热势的热疗组合物。
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3.发明申请MAGNETIC RESONANCE IMAGING CONTRAST AGENTS COMPRISING ZINC-CONTAINING MAGNETIC METAL OXIDE NANOPARTICLES 有权包含含锌金属氧化物纳米粒子的磁共振成像对比剂公开(公告)号：US20100143263A1
公开(公告)日：2010-06-10
申请号：US12527482
申请日：2008-04-11
申请人： Jinwoo Cheon , Young-wook Jun , Jung-tak Jang
发明人： Jinwoo Cheon , Young-wook Jun , Jung-tak Jang
CPC分类号： A61K49/1875 , A61K49/1836 , A61K49/1863 , A61K49/1866 , A61K49/1869 , B82Y5/00 , B82Y25/00 , C01G49/0063 , C01G49/009 , C01P2002/72 , C01P2002/85 , C01P2004/04 , C01P2006/42 , H01F1/0054 , Y10S977/773 , Y10S977/93
摘要： The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of “zinc-containing metal oxide nanoparticle—biologically/chemically active material” in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.
摘要翻译： 本发明涉及包含含锌水溶性金属氧化物纳米粒子并具有改善的对比效果的MRI造影剂。 含锌水溶性金属氧化物纳米颗粒的特征在于将锌添加到包含金属氧化物纳米颗粒的基质中或通过置换基质中的金属，导致MRI的对比度改善。 此外，本发明的含锌金属氧化物纳米颗粒包括具有“含锌金属氧化物纳米颗粒 - 生物/化学活性材料”的混合结构的MRI造影剂t，其中纳米颗粒与生物活性材料如 蛋白质，抗体和化学物质。
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4.发明授权Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles 有权包含含锌磁性金属氧化物纳米颗粒的磁共振成像造影剂公开(公告)号：US09375495B2
公开(公告)日：2016-06-28
申请号：US12527482
申请日：2008-04-11
申请人： Jinwoo Cheon , Young-wook Jun , Jung-tak Jang
发明人： Jinwoo Cheon , Young-wook Jun , Jung-tak Jang
CPC分类号： A61K49/1875 , A61K49/1836 , A61K49/1863 , A61K49/1866 , A61K49/1869 , B82Y5/00 , B82Y25/00 , C01G49/0063 , C01G49/009 , C01P2002/72 , C01P2002/85 , C01P2004/04 , C01P2006/42 , H01F1/0054 , Y10S977/773 , Y10S977/93
摘要： The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of “zinc-containing metal oxide nanoparticle—biologically/chemically active material” in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.
摘要翻译： 本发明涉及包含含锌水溶性金属氧化物纳米粒子并具有改善的对比效果的MRI造影剂。 含锌水溶性金属氧化物纳米颗粒的特征在于将锌添加到包含金属氧化物纳米颗粒的基质中或通过置换基质中的金属，导致MRI的对比度改善。 此外，本发明的含锌金属氧化物纳米颗粒包括具有“含锌金属氧化物纳米颗粒 - 生物/化学活性材料”的混合结构的MRI造影剂t，其中纳米颗粒与生物活性材料如 蛋白质，抗体和化学物质。
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公开(公告)号：US20110151019A1
公开(公告)日：2011-06-23
申请号：US12993293
申请日：2009-05-20
申请人： Jin Woo Cheon , Jung Tak Jang
发明人： Jin Woo Cheon , Jung Tak Jang
CPC分类号： C09K5/14 , A61K9/5115 , A61K41/0052 , A61N1/406
摘要： The present invention relates to a heat-generating composition, comprising a hetero-structure nanomaterial which comprises (a) a first material comprising at least one component selected from the group consisting of a metal, a metal chalcogen, a metal pnicogen, an alloy and a multi-component hybrid structure thereof; and (b) a second material comprising at least one component selected from the group consisting of metal, metal chalcogen, metal pnicogen, alloy and the multi-component hybrid structure thereof; wherein the first material is enclosed in the second material; wherein at least one of the first material and the second material comprise a magnetic material. The specific loss power of the present nanomaterial is much higher than that of conventional nanomaterials (e.g., 40-fold higher than commercially accessible Feridex) and may be controlled by changing compositions or ratios of the first material and/or the second material. The heat-generating nanomaterial of the present invention may be used in a variety of application fields, for example cancer hyperthermia.
摘要翻译： 本发明涉及一种发热组合物，其包含异质结构纳米材料，其包含（a）第一材料，其包含选自金属，金属硫族元素，金属原子，合金和 其多组分杂化结构; 和（b）包含选自金属，金属硫属元素，金属致癌剂，合金及其多组分混合结构中的至少一种成分的第二材料; 其中所述第一材料被封闭在所述第二材料中; 其中所述第一材料和所述第二材料中的至少一个包括磁性材料。 本纳米材料的特定损耗功率远高于常规纳米材料（例如，比商业上可接受的Feridex高40倍），并且可以通过改变第一材料和/或第二材料的组成或比例来控制。 本发明的发热纳米材料可以用于各种应用领域，例如癌症高热。
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