摘要:
The present invention if directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compounds containing the same and processes for preparing the same. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme such as obesity, non-insulin dependent diabetes, schizophrenia or bipolar disorder, obsessive-compulsive disorder, and the like.
摘要:
Bending elements for the triggering indicator of a belt tensioner. The triggering indicator for belt tensioners in motor vehicles includes a helical bending element made of a thermoplastic material such as polyamide, polyester or polyacetal.
摘要:
A glass wall (1) has two parallel wall elements (3), at least one of which consists of a material made of glass or a similar material, which is transparent to light, and behind which LEDs, with which the transparent wall element (3) can be lit translucently, are arranged in rows as illuminating devices. To achieve illumination of the glass wall (1) over the largest possible areas, provisions are made for LED light sources (7) to be arranged in a small number of illuminating groups on plate-like carriers (17) in the area of the front-side end of a narrow, elongated light chamber (6). A plurality of such light chambers are arranged separated by transverse walls (4, 4′, 5) in the vertical position next to each other or in the horizontal position one on top of another to form the glass wall (1). Each light chamber (6) has at least one translucent wall element (3) with an inner surface having a refractive and reflecting structure. The LED light sources (7) are equipped with focusing lenses (10) converging optically to divergence angles (a) of up to 20° and are arranged such that their light, emitted in the longitudinal direction of the respective light chamber (6), is partly reflected multiply on the inner surfaces of the wall elements (3) and is partly visible from the outside through at least one transparent wall element (3) over the length of the wall element.
摘要:
A device for lifting one or more flexible, flat parts such as stacked pap pasteboard, cardboard, plastic is disclosed. The device relies on the propensity of a bundle of such parts to flex up around its edge when compressed at a point away from that edge. In one embodiment, a compression device presses down on one bundle in a stack of several bundles of parts to be lifted and a second compression device presses down the underlying stack, thus opening up a gap between the upper bundle and lower stack. A lifting arm is driven into this gap, and a clamp presses down on the bundle above the lifting arm, grasping the bundle. Two retainers are extended down onto the lower stack to prevent the stack from moving as the bundle is lifted. Once contact between the lifted bundle and the remaining stack is broken, the retainers are withdrawn and the lifting device is maneuvered to a delivery position.
摘要:
A central locking system for use in a motor vehicle includes a pressure source generating preferably an under pressure and an over pressure. The source is connected to a series of pneumatic control units each including a pressure chamber, a control element arranged in the chamber for movement between two control positions, an opening in the chamber communicating with a space enclosing a valve which normally closes the opening and the space being provided with a discharging nipple which is coupled via the subsequent series connected control units to an indicator device. The indicator device is arranged in the field of view of the car operator. In this manner, the operating condition of locking devices which are outside of view of the operator can be reliably checked.
摘要:
PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
摘要:
The invention features compounds of formula (I): and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events using the compounds.
摘要:
In order to inspect at least one antenna branch (A1, A2, . . . An), in particular in a vehicle, a power level to be radiated is initially fed into the antenna branch, after which a power level which is reflected in the antenna branch is sensed. Then, a relationship is formed between the fed-in power level and the reflected power level in order to obtain a quality signal indicating the quality of the antenna branch. This procedure can be carried out successively when there are a plurality of antenna branches, in order to select, as a function of the respective quality signal, that antenna branch at which the reflected power level is lowest. In this way, on the one hand, it is possible to check the matching of the antenna branches while, on the other hand, it is possible to ensure that, for example when specific antenna branches are damaged, it is always possible to find other antenna branches for satisfactory communication.
摘要:
A heating system for a passenger compartment of a motor vehicle includes a heat exchanger located in the passenger compartment and a feeding conduit extending between the heat exchanger and the cooling circuit of the vehicle internal combustion engine and connected to the cooling circuit at a point downstream of the internal combustion engine in a direction of liquid flow. A return conduit extends between the heat exchanger and a delivery unit of the cooling circuit. The heating system also includes a shut-off device for blocking flow of heat to the heat exchanger. The shut-off device has first and second chambers and inlet and outlet ports communicating with the first chamber. A pressure port communicates with the second chamber and is connected with the feeding conduit. A wall separates the first and second chambers. The wall is movable between a first position in which it blocks communication between the inlet port and the outlet port, and a second position in which it closes the pressure port and provides for communication between the inlet and outlet ports.
摘要:
The invention relates to a method for producing virus-type particles containing an active substance. Proteins, which comprise a first amino acid sequence which is derived from a first virus protein, and fusion proteins are assembled in order to form the virus-type particles. The proteins and the fusion proteins are coexpressed in yeast cells.