公开(公告)号：US20110269231A1

公开(公告)日：2011-11-03

申请号：US13092548

申请日：2011-04-22

申请人： William L. Murphy ,  Gregory Allan Hudalla ,  Justin Koepsel ,  Jae Sung Lee ,  Sheeny Levengood

发明人： William L. Murphy ,  Gregory Allan Hudalla ,  Justin Koepsel ,  Jae Sung Lee ,  Sheeny Levengood

IPC分类号： C07K7/06 ,  C07K7/08 ,  C12N5/071 ,  C07K14/51 ,  C07K1/14 ,  C12N5/0735 ,  C07K2/00 ,  C07K14/475

CPC分类号： C07K14/51 ,  C07K14/485 ,  C07K14/49 ,  C07K14/503 ,  C07K14/52 ,  C12N5/0068 ,  C12N2533/30

摘要： Biomaterials presenting synthetic peptides and methods of preparing biomaterials are disclosed. More particularly, the disclosure is directed to biomaterials including a substrate including a synthetic peptide thereon, wherein the synthetic peptide is selected from synthetic proteoglycan-binding peptides, synthetic glycosaminoglycan-binding peptides, and combinations thereof. The present disclosure is further directed to methods of preparing the biomaterials for use in sequestering endogenous proteoglycans and endogenous glycosaminoglycans, increasing stem cell proliferation, reducing spontaneous stem cell differentiation, and enhancing induced osteogenic differentiation of mesenchymal stem cells.

摘要翻译： 公开了提供合成肽的生物材料和制备生物材料的方法。 更具体地，本公开涉及生物材料，包括其上包含合成肽的底物，其中所述合成肽选自合成的蛋白多糖结合肽，合成的糖胺聚糖结合肽及其组合。 本公开进一步涉及制备用于螯合内源性蛋白聚糖和内源性糖胺聚糖的生物材料的方法，增加干细胞增殖，减少自发干细胞分化以及增强间充质干细胞的诱导成骨分化。