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公开(公告)号：US06799121B2
公开(公告)日：2004-09-28
申请号：US09804866
申请日：2001-03-13
申请人： Ivan K. Chu , Tai-Chu Lau , K. W. Michael Siu
发明人： Ivan K. Chu , Tai-Chu Lau , K. W. Michael Siu
IPC分类号： G01N3350
CPC分类号： G01N33/6848 , G01N33/6818 , G06F19/22
摘要： A strategy for semiautomatic sequencing of argentinated (silver-containing) oligopeptides is described. The method of sequencing described is based on a search algorithm that identifies a triplet peak relationship in a product ion spectrum of the [M+Ag]+ ion of an oligopeptide. The ions that constitute a triplet are [bn+OH+Ag]+, [bn−H+Ag]+, and [an−H+Ag]+, which are separated by 18 and 28 m/z units, respectively. The difference in the m/z values of adjacent triplets identifies the residue that is “cleaved”. Observation of the [yn+H+Ag]+ ion containing the cleaved residue confirms the assignment.
摘要翻译： 描述了含有（含银）寡肽的半自动测序策略。 所描述的测序方法是基于识别寡肽的[M + Ag] +离子的产物离子谱中的三重态峰关系的搜索算法。 构成三线态的离子是[bn + OH + Ag] +，[bn-H + Ag] +和[an-H + Ag] +，它们被18和28m / z单位。 相邻三联体的m / z值的差异表示“切割”的残基。 含有裂解残基的[yn + H + Ag] +离子的观察证实了分配。
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公开(公告)号：US08329399B2
公开(公告)日：2012-12-11
申请号：US12447398
申请日：2007-10-26
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/16 , G01N33/57442 , G01N33/6893 , G01N2500/10
摘要： Methods for detecting endometrial diseases or an endometrium phase in a subject are described comprising measuring endometrial markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for endometrial diseases, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for endometrial diseases employing endometrial markers, polynucleotides encoding the markers, and/or binding agents for the markers.
摘要翻译： 描述了检测受试者子宫内膜疾病或子宫内膜期的方法，其包括测量子宫内膜标志物或编码来自受试者的样品中的标记物的多核苷酸。 本发明还提供子宫内膜疾病的定位或成像方法以及用于实施本发明的方法的试剂盒。 本发明还考虑了使用子宫内膜标志物，编码标记物的多核苷酸和/或用于标记物的结合剂的子宫内膜疾病的治疗应用。
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公开(公告)号：US20110104062A1
公开(公告)日：2011-05-05
申请号：US12866567
申请日：2009-02-06
申请人： K. W. Michael Siu , Ranju Ralhan , Ajay Matta , Leroi V. DeSouza
发明人： K. W. Michael Siu , Ranju Ralhan , Ajay Matta , Leroi V. DeSouza
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/158 , G01N33/57484
摘要： The invention provides markers and methods for detecting head-and-neck precancers, (including OPLs), cancers and related disease conditions in a subject. The invention also provides localization and imaging methods for head-and-neck precancers (including OPLs) and cancers, along with kits for carrying out methods of the invention. The invention further provides therapeutic applications for head-and-neck precancers (including OPLs) and cancers which employ head-and-neck precancer and cancer markers, polynucleotides encoding the markers, and binding agents for the markers.
摘要翻译： 本发明提供了用于检测受试者的头颈部预处理剂（包括OPL），癌症和相关疾病状况的标记物和方法。 本发明还提供了头颈部预干燥剂（包括OPL）和癌症的定位和成像方法，以及用于实施本发明方法的试剂盒。 本发明进一步提供了用于头颈部预处理剂（包括OPL）和使用头颈前体癌症和癌症标志物的癌症，编码标记物的多核苷酸和用于标记物的结合剂的治疗应用。
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公开(公告)号：US07803273B2
公开(公告)日：2010-09-28
申请号：US11707195
申请日：2007-02-13
申请人： K. W. Michael Siu
发明人： K. W. Michael Siu
CPC分类号： B01D29/03
摘要： A filter comprises at least one filtration unit with a filtration passage having an inlet and an outlet, wherein the filtration unit includes at least one groove formed in an inlet side surface of the filtration unit, said at least one groove extending to the inlet and dimensioned to hold back substances which may clog the filtration passage, by means of upper edges of said at least one groove. According to the present invention, by forming at least one groove in an inlet side surface of the filtration unit, the filtration passages of the filter can be effectively prevented from being clogged.
摘要翻译： 过滤器包括至少一个具有过滤通道的过滤单元，过滤通道具有入口和出口，其中过滤单元包括形成在过滤单元的入口侧表面中的至少一个凹槽，所述至少一个凹槽延伸到入口和尺寸 通过所述至少一个凹槽的上边缘阻挡可能堵塞过滤通道的物质。 根据本发明，通过在过滤单元的入口侧表面形成至少一个槽，可以有效地防止过滤器的过滤通道堵塞。
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公开(公告)号：US08921053B2
公开(公告)日：2014-12-30
申请号：US12866567
申请日：2009-02-06
申请人： K. W. Michael Siu , Ranju Ralhan , Ajay Matta , Leroi V. DeSouza
发明人： K. W. Michael Siu , Ranju Ralhan , Ajay Matta , Leroi V. DeSouza
IPC分类号： G01N33/53
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/158 , G01N33/57484
摘要： The invention provides markers and methods for detecting head-and-neck precancers, (including OPLs), cancers and related disease conditions in a subject. The invention also provides localization and imaging methods for head-and-neck precancers (including OPLs) and cancers, along with kits for carrying out methods of the invention. The invention further provides therapeutic applications for head-and-neck precancers (including OPLs) and cancers which employ head-and-neck precancer and cancer markers, polynucleotides encoding the markers, and binding agents for the markers.
摘要翻译： 本发明提供了用于检测受试者的头颈部预处理剂（包括OPL），癌症和相关疾病状况的标记物和方法。 本发明还提供了头颈部预干燥剂（包括OPL）和癌症的定位和成像方法，以及用于实施本发明方法的试剂盒。 本发明进一步提供了用于头颈部预处理剂（包括OPL）和使用头颈前体癌症和癌症标志物的癌症，编码标记物的多核苷酸和用于标记物的结合剂的治疗应用。
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6.发明申请公开(公告)号：US20110275065A1
公开(公告)日：2011-11-10
申请号：US13102638
申请日：2011-05-06
申请人： Paul Walfish , Ranju Ralhan , K. W. Michael Siu
发明人： Paul Walfish , Ranju Ralhan , K. W. Michael Siu
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/566
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/158 , G01N2333/70503
摘要： Methods for detecting thyroid cancer or thyroid cancer status in a subject are described comprising measuring novel markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for thyroid cancer, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for thyroid cancer employing the novel markers, polynucleotides encoding the markers, and/or binding agents for the markers.
摘要翻译： 描述了用于检测受试者中甲状腺癌或甲状腺癌状态的方法，包括测量来自受试者的样品中编码标记的新标记物或多核苷酸。 本发明还提供甲状腺癌的定位或成像方法以及用于实施本发明方法的试剂盒。 本发明还考虑了使用新型标志物，编码标记物的多核苷酸和/或标记物的结合剂的甲状腺癌的治疗应用。
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