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    METHOD AND SYSTEM FOR ESTIMATING RENAL FUNCTION
    3.
    发明申请
    METHOD AND SYSTEM FOR ESTIMATING RENAL FUNCTION 有权

    公开(公告)号：US20230037869A1

    公开(公告)日：2023-02-09

    申请号：US17789402

    申请日：2020-12-25

    Applicant: Kagami Inc. ,  National Institutes of Biomedical Innovation, Health and Nutrition

    Inventor： Masashi MITA ,  Tatsuhiko IKEDA ,  Tomonori KIMURA

    IPC: G01N33/68 ,  G01N30/86

    Abstract: The present invention provides a method comprising a step of estimating the kidney function of an arbitrary subject by a regression analysis which employs the amount of a D, L-amino acid in a biological sample from the arbitrary subject as an explanatory variable and employs the amount of filtrated glomeruli in the arbitrary subject as an object variable, by employing a previously determined formula (I): Y=a1·X1+a2·X2+ . . . +an·Xn+b (I) [wherein a1 to an independently represent a constant obtained by the regression analysis; X1 to Xn independently represent a variable of the amount of the D,L-amino acid which is selected by the regression analysis; and b represents a constant obtained by the regression analysis] on the basis of the Y value calculated from the amount of the D, L-amino acid in the biological sample from the object to be evaluated. Also provided is a system for carrying out the method.

    METHOD FOR DETERMINING GLOMERULAR FILTRATION ABILITY
    5.
    发明申请
    METHOD FOR DETERMINING GLOMERULAR FILTRATION ABILITY 有权

    公开(公告)号：US20210373031A1

    公开(公告)日：2021-12-02

    申请号：US17286359

    申请日：2019-10-17

    Applicant: Kagami Inc. ,  National Institutes of Biomedical, Innovation, Health and Nutrition

    Inventor： Masashi MITA ,  Tatsuhiko IKEDA ,  Tomonori KIMURA

    IPC: G01N33/68

    Abstract: The present invention provides a method for determining glomerular filtration ability on the basis of the amount of D-serine in the blood. The present invention provides a blood analysis system which includes a storage unit, an analysis measurement unit, a data processing unit and a glomerular filtration ability output unit, wherein: the storage unit stores the correlation equation between the amount of D-serine in the blood and glomerular filtration ability; the analysis measurement unit separates and quantifies the amount of D-serine in the blood; the data processing unit calculates glomerular filtration ability by inputting the D-serine amount into the correlation equation stored in the storage unit; and a pathology information output unit outputs glomerular filtration ability information.

    METHOD FOR PROVIDING INFORMATION PERTAINING TO CANCER, SYSTEM FOR PROVIDING INFORMATION PERTAINING TO CANCER, AND METHOD FOR TREATING CANCER
    6.
    发明申请
    METHOD FOR PROVIDING INFORMATION PERTAINING TO CANCER, SYSTEM FOR PROVIDING INFORMATION PERTAINING TO CANCER, AND METHOD FOR TREATING CANCER 有权

    公开(公告)号：US20250003971A1

    公开(公告)日：2025-01-02

    申请号：US18688730

    申请日：2022-09-05

    Applicant: KAGAMI INC. ,  KEIO UNIVERSITY

    Inventor： Tomohisa SUJINO ,  Takanori KANAI ,  Kai TSUGARU ,  Jumpei SASABE ,  Masashi MITA

    IPC: G01N33/574

    Abstract: There are many options in cancer evaluation and treatment, and it is desired to ascertain the characteristics and conditions of individual patients and improve treatment efficacy and cost performance. Provided is a method for providing information pertaining to a cancer in a subject using an indicator based on the amount of D-amino acid in a biological sample from the subject, wherein the information is selected from the group consisting of: a verification result of the validity of a test or diagnosis result of the cancer in the subject; a classification of the degree of progression of the cancer in the subject; a result of a prognosis prediction for the cancer in the subject; and information for selecting a treatment means for the cancer in the subject. Also provided is a system for providing information pertaining to a cancer in a subject. Further provided is a cancer treatment method for treating a subject via a cancer treatment means selected on the basis of the information provided by the method or the system.

    KIDNEY DISEASE PROGNOSIS PREDICTION METHOD AND SYSTEM
    7.
    发明申请
    KIDNEY DISEASE PROGNOSIS PREDICTION METHOD AND SYSTEM 有权

    公开(公告)号：US20220003774A1

    公开(公告)日：2022-01-06

    申请号：US17374777

    申请日：2021-07-13

    Applicant: Osaka University ,  Kagami Inc.

    Inventor： Yoshitaka ISAKA ,  Tomonori KIMURA ,  Keiko YASUDA ,  Kenji Hamase ,  Masashi MITA

    IPC: G01N33/68 ,  G01N33/72

    Abstract: The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.

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