公开(公告)号：US20240127956A1

公开(公告)日：2024-04-18

申请号：US18488373

申请日：2023-10-17

申请人： Osaka University ,  National Institutes of Biomedical Innovation, Health and Nutrition ,  Kagami Inc.

发明人： Yoshitaka ISAKA ,  Tomonori KIMURA ,  Shihoko KIMURA ,  Masashi MITA

IPC分类号： G16H50/20 ,  G01N33/68 ,  G16H20/10

CPC分类号： G16H50/20 ,  G01N33/6893 ,  G16H20/10 ,  G01N2800/52

摘要： Provided herein is a method for providing information about virus infection and/or virus infection disease in a subject, comprising: making a determination on the detection and/or stage classification of virus infection and/or virus infection disease in the subject using an indicator associated with a D-amino acid in the subject; and providing information about virus infection and/or virus infection disease in the subject based on the results of the determination.

公开(公告)号：US20220003774A1

公开(公告)日：2022-01-06

申请号：US17374777

申请日：2021-07-13

申请人： Osaka University ,  Kagami Inc.

发明人： Yoshitaka ISAKA ,  Tomonori KIMURA ,  Keiko YASUDA ,  Kenji Hamase ,  Masashi MITA

IPC分类号： G01N33/68 ,  G01N33/72

摘要： The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.

公开(公告)号：US20240307375A1

公开(公告)日：2024-09-19

申请号：US18574883

申请日：2022-06-22

申请人： OSAKA UNIVERSITY ,  KYOTO UNIVERSITY

发明人： Ryu NAGATA ,  Yoshitaka ISAKA ,  Takeshi YAMAMOTO ,  Hiroaki YONISHI ,  Tamotsu YOSHIMORI ,  Maho HAMASAKI ,  Yasuo MORI

IPC分类号： A61K31/496 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4995

CPC分类号： A61K31/496 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4995

摘要： An object of this invention is to provide a pharmaceutical composition for preventing and/or treating acute kidney injury, and an autophagy activator. The invention relates to, for example, a pharmaceutical composition for preventing and/or treating acute kidney injury, comprising a compound represented by formula (1), a salt thereof, or a prodrug thereof:






wherein
A is an optionally substituted benzene ring;
B is an optionally substituted aryl or an optionally substituted heteroaryl;
X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom;
of is a single or double bond when Y is a carbon atom, or
of is a single bond when Y is a nitrogen atom;
each R1 independently represents lower alkyl, or
two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or
two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y;
p is 0, 1, or 2; or
(R1)p is oxo.