公开(公告)号：US20140010845A1

公开(公告)日：2014-01-09

申请号：US13879509

申请日：2011-10-14

Applicant: Jens Brimnes ,  Kaare Lund

Inventor： Jens Brimnes ,  Kaare Lund

IPC: A61K39/35

CPC classification number: A61K39/35 ,  A61K38/00 ,  A61K39/36 ,  A61K2039/541 ,  A61K2039/577 ,  A61K2039/58

Abstract: The present invention relates to the treatment of a hypersensitivity immune response, such as allergic rhinitis or asthma, via bystander suppression by use of an antigen unrelated to the allergen triggering the hypersensitivity immune response in an individual to be treated, wherein the antigen is obtainable from the source material comprising the “triggering” allergen.

Abstract translation: 本发明涉及通过使用与变应原无关的抗原通过旁观者抑制来治疗过敏性鼻炎或哮喘的过敏性免疫应答，从而引发在待治疗的个体中的超敏反应免疫应答，其中所述抗原可从 源材料包含“触发”变应原。

公开(公告)号：US06753421B2

公开(公告)日：2004-06-22

申请号：US09544934

申请日：2000-04-07

Applicant: Henrik Stender ,  Kaare Lund ,  Tina Anderson Mollerup

Inventor： Henrik Stender ,  Kaare Lund ,  Tina Anderson Mollerup

IPC: C07H2102

CPC classification number: C07K14/003 ,  C12Q1/689

Abstract: Novel hybridisation assay probes and mixtures of such probes for detecting a target sequence of one or mycobacteria optionally present in a sample. The probes may suitable be directed to target sequences of mycobacterial rDNA, precursor rRNA or rRNA, said probes being capable of forming detectable hybrids. The probes are in particular directed to mycobacterial rDNA, to precursor rRNA, or to 23S, 16S or 5S rRNA. The probes are useful for detecting the organisms in test samples such as sputum, laryngeal swabs, gastric lavage, bronchial washings, biopsies, aspirates, expectorates, body fluids (spinal, pleural, pericardial synovial, blood, pus, bone marrow), urine, tissue sections as well as food samples, soil, air and water samples, and cultures thereof.

Abstract translation: 新型杂交测定探针和这种探针的混合物，用于检测任选存在于样品中的一种或分枝杆菌的靶序列。 探针可以适用于分枝杆菌rDNA，前体rRNA或rRNA的靶序列，所述探针能够形成可检测的杂交体。 探针特别针对分枝杆菌rDNA，前体rRNA或23S，16S或5S rRNA。 探针可用于检测试验样品中的生物，如痰液，喉拭子，胃灌洗液，支气管洗液，活组织检查，抽吸物，痰液，体液（脊髓，胸膜，心包滑膜，血液，脓液，骨髓），尿液， 组织切片以及食物样品，土壤，空气和水样品及其培养物。

公开(公告)号：US20120100163A1

公开(公告)日：2012-04-26

申请号：US13274210

申请日：2011-10-14

Applicant: Jens BRIMNES ,  Kaare LUND

Inventor： Jens BRIMNES ,  Kaare LUND

IPC: A61K39/00 ,  A61P37/06

CPC classification number: A61K39/36 ,  A61K39/35 ,  A61K2039/542 ,  A61K2039/544 ,  A61K2039/545 ,  A61K2039/58

Abstract: The present invention relates to antigens and methods for the suppression of a hypersensitivity immune response via bystander suppression with an antigen unrelated to the allergen triggering a hypersensitivity immune response such as an allergic response in an individual. Treatment regiments covering the administering the unrelated antigen to the oral cavity (e.g. sublingual mucosa) combined with the administration of the unrelated antigen to either the respiratory tract, gastro-intestinal tract or skin in a simultaneous, contemporaneous, separate or sequential manner is provided.

Abstract translation: 本发明涉及抗原和通过旁观者抑制的过敏免疫应答的方法，所述抗原与过敏原无关的抗原触发了超敏反应免疫应答，例如个体的过敏反应。 提供了涉及向口腔（例如舌下粘膜）施用无关抗原与将不相关抗原以同时，同时期，分开或连续方式施用于呼吸道，胃肠道或皮肤的治疗团。

公开(公告)号：US20130216582A1

公开(公告)日：2013-08-22

申请号：US13879486

申请日：2011-10-14

Applicant: Jens Brimnes ,  Kaare Lund

Inventor： Jens Brimnes ,  Kaare Lund

IPC: A61K39/36 ,  A61K39/35

CPC classification number: A61K39/36 ,  A61K39/35 ,  A61K2039/542 ,  A61K2039/544 ,  A61K2039/545 ,  A61K2039/58

Abstract: The present invention relates to antigens and methods for the suppression of a hypersensitivity immune response via bystander suppression with an antigen unrelated to the allergen triggering a hypersensitivity immune response such as an allergic response in an individual. Treatment regiments covering the administering the unrelated antigen to the oral cavity (e.g. sublingual mucosa) combined with the administration of the unrelated antigen to either the respiratory tract, gastro-intestinal tract or skin in a simultaneous, contemporaneous, separate or sequential manner is provided.

Abstract translation: 本发明涉及抗原和通过旁观者抑制的过敏免疫应答的方法，所述抗原与过敏原无关的抗原触发了超敏反应免疫应答，例如个体的过敏反应。 提供了涉及向口腔（例如舌下粘膜）施用无关抗原与将不相关抗原以同时，同时期，分开或连续方式施用于呼吸道，胃肠道或皮肤的治疗团。

公开(公告)号：US20120100164A1

公开(公告)日：2012-04-26

申请号：US13274232

申请日：2011-10-14

Applicant: Jens BRIMNES ,  Kaare Lund

Inventor： Jens BRIMNES ,  Kaare Lund

IPC: A61K39/00 ,  A61P37/06

CPC classification number: A61K39/35 ,  A61K38/00 ,  A61K39/36 ,  A61K2039/541 ,  A61K2039/577 ,  A61K2039/58

Abstract: The present invention relates to the treatment of a hypersensitivity immune response, such as allergic rhinitis or asthma, via bystander suppression by use of an antigen unrelated to the allergen triggering the hypersensitivity immune response in an individual to be treated, wherein the antigen is obtainable from the source material comprising the “triggering” allergen.

Abstract translation: 本发明涉及通过使用与变应原无关的抗原通过旁观者抑制来治疗过敏性鼻炎或哮喘的过敏性免疫应答，从而引发在待治疗的个体中的超敏反应免疫应答，其中所述抗原可从 源材料包含“触发”变应原。