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    Method for preparing nano-scale or amorphous particle using solid fat as a solvent
    2.
    发明授权
    Method for preparing nano-scale or amorphous particle using solid fat as a solvent 有权
    使用固体脂肪作为溶剂制备纳米级或无定形颗粒的方法

    公开(公告)号：US08211470B2

    公开(公告)日：2012-07-03

    申请号：US10596178

    申请日：2004-11-11

    申请人： Kab-Sig Kim

    发明人： Kab-Sig Kim

    IPC分类号： A61K9/14

    CPC分类号： A61K9/5089 ,  A61K9/1694 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5192

    摘要： The present invention relates to a method for preparing nanoscale or amorphous particles using solid fat as a solvent. According to the present invention, nanoscale or amorphous particles of active ingredients are prepared by using fat as a solvent, wherein the fat is in solid phase at room temperature. The nanoscale or amorphous particles of active ingredients can be advantageously used in medicine, cosmetics, functional foods or the like.

    摘要翻译： 本发明涉及使用固体脂肪作为溶剂制备纳米尺度或无定形颗粒的方法。 根据本发明，通过使用脂肪作为溶剂制备活性成分的纳米级或无定形颗粒，其中脂肪在室温下为固相。 活性成分的纳米尺寸或无定形颗粒可以有利地用于医药，化妆品，功能食品等。

    Method For Preparing Nano-Scale Particle of Active Material
    3.
    发明申请
    Method For Preparing Nano-Scale Particle of Active Material 审中-公开
    制备活性物质纳米级粒子的方法

    公开(公告)号：US20090202646A1

    公开(公告)日：2009-08-13

    申请号：US12299500

    申请日：2007-05-03

    申请人： Kab Sig Kim ,  Young Tai Cho

    发明人： Kab Sig Kim ,  Young Tai Cho

    IPC分类号： A61K9/14

    CPC分类号： A61K9/146 ,  A61K9/1694 ,  A61K9/5192

    摘要： Disclosed herein is a method for preparing nanoscale particles of active material with using a gas of a supercritical fluid, by dissolving an active material into a solvent which is in solid phase at room temperature, to produce nanoscale particles of the active materials which can be advantageously used in medicine, cosmetics, functional foods or the like.

    摘要翻译： 本文公开了一种使用超临界流体的气体制备纳米尺寸活性材料颗粒的方法，其通过将活性材料溶解在室温下为固相的溶剂中以产生活性材料的纳米尺寸颗粒，其可以有利地 用于医药，化妆品，功能食品等。

    OXALIPLATIN NANOPARTICLES AND METHOD FOR PREPARING SAME
    6.
    发明申请
    OXALIPLATIN NANOPARTICLES AND METHOD FOR PREPARING SAME 有权
    OXALIPLATIN纳米颗粒及其制备方法

    公开(公告)号：US20120177728A1

    公开(公告)日：2012-07-12

    申请号：US13497208

    申请日：2010-09-20

    申请人： Sung Jae Lee ,  Young Hoon Kim ,  Sang Heon Lee ,  Kab Sig Kim

    发明人： Sung Jae Lee ,  Young Hoon Kim ,  Sang Heon Lee ,  Kab Sig Kim

    IPC分类号： A61K31/282 ,  A61K9/48 ,  B32B5/16 ,  A61K9/00 ,  A61P35/00 ,  B82Y40/00 ,  B82Y5/00

    CPC分类号： A61K9/146 ,  A61K9/0095 ,  A61K9/10 ,  A61K9/2027 ,  A61K9/4866 ,  A61K31/555 ,  A61K47/38 ,  Y10T428/2982

    摘要： The present invention relates to a nanoparticle of oxaliplatin, which is a water-soluble active substance, a pharmaceutical composition containing the same, and a method for preparing an orally administrable oxaliplatin nanoparticle by emulsifying a lipid mixture solution wherein a solid lipid and a surfactant are mixed in an aqueous mixture solution wherein oxaliplatin and a specific cosolvent are mixed and then removing the solid lipid and the cosolvent using a supercritical fluid gas.By providing oxaliplatin, which is currently available only in injection form for parenteral administration, in the form of a nanoparticle, the present invention allows for the development of orally administrable oxaliplatin which is stable against gastric acid and has improved bioavailability, thereby improving patient compliance through avoiding the inconvenience of injection and greatly reducing medical cost. Since the oxaliplatin nanoparticle can be prepared economically using a relatively inexpensive supercritical fluid producing facility, it can be prepared via a simple process with high yield in commercial scale.

    摘要翻译： 本发明涉及奥沙利铂的纳米粒子，其为水溶性活性物质，含有该纳米粒子的药物组合物，以及通过乳化脂质混合溶液制备口服奥沙利铂纳米粒子的方法，其中固体脂质和表面活性剂为 在其中混合奥沙利铂和特定共溶剂的混合物水溶液中混合，然后使用超临界流体气体除去固体脂质和助溶剂。 通过提供目前仅以注射用于肠胃外给药的奥沙利铂作为纳米颗粒的形式，本发明允许开发对胃酸稳定的可口服奥沙利铂，并且具有改善的生物利用度，从而通过 避免注射带来的不便，大大降低医疗成本。 由于奥沙利铂纳米颗粒可以使用相对便宜的超临界流体生产设备经济地制备，所以可以通过工业规模的高产率的简单方法制备。

    Method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed beverage
    7.
    发明授权
    Method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed beverage 失效
    分散饮料用植物甾醇和分散饮料中粒径为纳米级的植物甾醇分散饮料的方法

    公开(公告)号：US07994157B2

    公开(公告)日：2011-08-09

    申请号：US10398001

    申请日：2001-09-28

    申请人： Won-Tae Yoon ,  Kab-Sig Kim ,  Bo-Chun Kim ,  Jung-Hee Han ,  Hyung-Pyo Hong

    发明人： Won-Tae Yoon ,  Kab-Sig Kim ,  Bo-Chun Kim ,  Jung-Hee Han ,  Hyung-Pyo Hong

    IPC分类号： A61K31/56 ,  A61K31/23 ,  A61K31/70 ,  A23L2/02 ,  A23L2/38

    CPC分类号： A23L2/52 ,  A23C9/152 ,  A23L33/11 ,  Y10S514/951

    摘要： Disclosed are a method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed beverage. The dispersion of plant sterols starts with the admixing of plant sterol to at least one emulsifier selected from the group consisting of sucrose fatty acid ester, sorbitan fatty acid ester and polyglycerine fatty acid ester, followed by melting the admixture by heating at 60 to 200° C. Afterwards, the molten substance is mixed with an aqueous beverage alone or an emulsifier-containing aqueous beverage in state of its own molten type or power type. This resulting mixture is stirred at a high speed to give a dispersion of plant sterols in an aqueous beverage. The beverage is superior in bioavailability, having good mouth feel, transparent aspect and no influence on the characteristic taste, flavor and color of the beverages.

    摘要翻译： 公开了分散饮料用植物性甾醇和分散饮料中粒径为纳米级的植物甾醇分散饮料的方法。 植物甾醇的分散体从植物甾醇与至少一种选自蔗糖脂肪酸酯，脱水山梨糖醇脂肪酸酯和聚甘油脂肪酸酯的乳化剂混合开始，然后通过在60〜200℃加热熔融混合物 C.然后，将熔融物与单独的含水饮料或含乳化剂的含水饮料以其自身的熔融型或动力型混合。 将所得混合物高速搅拌，得到植物甾醇在含水饮料中的分散体。 该饮料具有优越的生物利用度，具有良好的口感，透明的方面，并且不影响饮料的特征味道，风味和颜色。

    Bacillus amyloliquefaciens KTGB0202 and control method of plant pathogenic fungi using that
    8.
    发明授权
    Bacillus amyloliquefaciens KTGB0202 and control method of plant pathogenic fungi using that 失效
    解淀粉芽孢杆菌KTGB0202和植物致病真菌的控制方法

    公开(公告)号：US07615366B2

    公开(公告)日：2009-11-10

    申请号：US10583076

    申请日：2004-12-07

    申请人： Kab-Sig Kim ,  Woon-Hyung Yeo

    发明人： Kab-Sig Kim ,  Woon-Hyung Yeo

    IPC分类号： A01N25/00 ,  C12N1/20

    CPC分类号： A01N63/00 ,  A01N63/02 ,  C12R1/07 ,  Y10S435/832

    摘要： The present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 and a method for controlling plant pathogens using the same. More particularly, the present invention relates to a novel microorganism Bacillus amyloliquefaciens KTGB0202 (accession number: KCTC 10564BP) bacterium which has an excellent control effect against crop powdery mildew and a broad spectrum of antifungal activity against plant pathogenic fungi and inhibits tobacco mosaic virus infection, as well as an eco-friendly bacterial culture broth for controlling powdery mildew, which contains the same. Also, the present invention relates to antifungal substance KTGB0202AFO1 obtained by extraction and purification from the Bacillus amyloliquefaciens KTGB0202 bacteria. The inventive Bacillus amyloliquefaciens KTGB0202 bacteria have a broad spectrum of antifungal activity, and are excellent in activity continuance and used for controlling various plant pathogens, including powdery mildew.

    摘要翻译： 本发明涉及一种新型微生物解淀粉芽孢杆菌KTGB0202及其使用该植物病原体的方法。 更具体地说，本发明涉及一种对作物白粉病具有优异防除效果和对植物病原真菌的广谱抗真菌活性和抑制烟草花叶病毒感染的新型微生物解淀粉芽孢杆菌KTGB0202（登录号：KCTC 10564BP）细菌， 以及含有相同的防治白粉病的环保细菌培养液。 此外，本发明涉及通过从解淀粉芽孢杆菌KTGB0202细菌提取和纯化获得的抗真菌物质KTGB0202AFO1。 本发明的解淀粉芽孢杆菌KTGB0202细菌具有广谱的抗真菌活性，活性连续性优异，用于防治各种植物病原体，包括白粉病。

    Method for preparing nano-particles utilizing a saccharide anti-coagulant
    10.
    发明授权
    Method for preparing nano-particles utilizing a saccharide anti-coagulant 有权
    利用糖类抗凝剂制备纳米颗粒的方法

    公开(公告)号：US08828445B2

    公开(公告)日：2014-09-09

    申请号：US13635717

    申请日：2011-03-22

    申请人： Kab Sig Kim ,  Joo Won Park

    发明人： Kab Sig Kim ,  Joo Won Park

    IPC分类号： A61K9/50

    CPC分类号： A61K9/5123

    摘要： The present invention relates to a method for preparing nano-particles, and more particularly, to a method for preparing nano-particles containing active materials in a simple and highly efficient manner through a grinding process.

    摘要翻译： 本发明涉及一种制备纳米颗粒的方法，更具体地涉及通过研磨方法以简单和高效的方式制备含有活性材料的纳米颗粒的方法。