公开(公告)号：US08617490B2

公开(公告)日：2013-12-31

申请号：US12832030

申请日：2010-07-07

申请人： Kai Tsung Teng ,  Yueh-Hui Lin ,  Thomas Y. S. Shen

发明人： Kai Tsung Teng ,  Yueh-Hui Lin ,  Thomas Y. S. Shen

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC分类号： B01L3/502 ,  B01L2200/0621 ,  B01L2300/0809 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N2035/0429

摘要： A reaction cassette for biochemical assay, a biochemical assay device including the reaction cassette, and a biochemical assay method performed by using the biochemical assay device are provided. The reaction cassette includes a first space, a second space, a third space, and an inner wall. The first space is configured to accommodate liquid and includes a first opening facing upward. The second space includes a second opening whose direction is perpendicular to the direction of the first opening. The first space and the second space are disposed such that when the reaction cassette is rotated, liquid in the first space can flow into the second space. The third space is located under the first space and includes a third opening whose direction is the same as the direction of the first opening. The inner wall connects the second opening and the third opening, which serves as a liquid flow channel between the second space and the third space.

摘要翻译： 提供了用于生物化学测定的反应盒，包括该反应盒的生物化学测定装置以及通过使用该生化测定装置进行的生物化学测定方法。 反应盒包括第一空间，第二空间，第三空间和内壁。 第一空间构造成容纳液体并且包括面向上的第一开口。 第二空间包括其方向垂直于第一开口的方向的第二开口。 第一空间和第二空间被布置成使得当反应盒旋转时，第一空间中的液体可以流入第二空间。 第三空间位于第一空间的下方，具有与第一开口方向相同的第三开口。 内壁连接第二开口和第三开口，其作为在第二空间和第三空间之间的液体流动通道。

公开(公告)号：US20110104731A1

公开(公告)日：2011-05-05

申请号：US12832030

申请日：2010-07-07

申请人： Kai Tsung TENG ,  Yueh-Hui LIN ,  Thomas Y. S. SHEN

发明人： Kai Tsung TENG ,  Yueh-Hui LIN ,  Thomas Y. S. SHEN

IPC分类号： C12M1/10 ,  C12Q1/02

CPC分类号： B01L3/502 ,  B01L2200/0621 ,  B01L2300/0809 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N2035/0429

摘要： A reaction cassette for biochemical assay, a biochemical assay device including the reaction cassette, and a biochemical assay method performed by using the biochemical assay device are provided. The reaction cassette includes a first space, a second space, a third space, and an inner wall. The first space is configured to accommodate liquid and includes a first opening facing upward. The second space includes a second opening whose direction is perpendicular to the direction of the first opening. The first space and the second space are disposed such that when the reaction cassette is rotated, liquid in the first space can flow into the second space. The third space is located under the first space and includes a third opening whose direction is the same as the direction of the first opening. The inner wall connects the second opening and the third opening, which serves as a liquid flow channel between the second space and the third space.

摘要翻译： 提供了用于生物化学测定的反应盒，包括该反应盒的生物化学测定装置以及通过使用该生化测定装置进行的生物化学测定方法。 反应盒包括第一空间，第二空间，第三空间和内壁。 第一空间构造成容纳液体并且包括面向上的第一开口。 第二空间包括其方向垂直于第一开口的方向的第二开口。 第一空间和第二空间被布置成使得当反应盒旋转时，第一空间中的液体可以流入第二空间。 第三空间位于第一空间的下方，具有与第一开口方向相同的第三开口。 内壁连接第二开口和第三开口，其作为在第二空间和第三空间之间的液体流动通道。

公开(公告)号：US20100089775A1

公开(公告)日：2010-04-15

申请号：US12641406

申请日：2009-12-18

申请人： Guan-Ting CHEN ,  Yueh-Hui Lin ,  Kai-Tsung Teng ,  Sz-Hau Chen ,  Thomas Y. S. Shen

发明人： Guan-Ting CHEN ,  Yueh-Hui Lin ,  Kai-Tsung Teng ,  Sz-Hau Chen ,  Thomas Y. S. Shen

IPC分类号： G01N27/26

CPC分类号： G01N27/3274

摘要： An electrochemical test strip, an electrochemical test system, and a measurement method using the same are provided. The electrochemical test strip includes an insulating substrate, an electrode system formed on the insulating substrate, and an insulating layer formed on the electrode system. The electrode system includes a set of measurement electrodes, a set of identifying electrodes, and a resistive path having a predetermined resistance value. The set of identifying electrodes is made of metal material, and the resistive path is made of non-metal material. The set of measurement electrodes includes a reference electrode and a working electrode insulated from each other, and the set of identifying electrodes includes a first identifying electrode and a second identifying electrode connected with each other through the resistive path. The insulating layer covers a part of the electrode system, wherein a part of the electrode system not covered by the insulating layer forms a reaction region with a supply port. When a sample is injected into the supply port of the reaction region, the injected sample reaches the set of measurement electrodes and the set of identifying electrodes in sequence.

摘要翻译： 提供电化学测试条，电化学测试系统以及使用其的测量方法。 电化学测试条包括绝缘基板，形成在绝缘基板上的电极系统和形成在电极系统上的绝缘层。 电极系统包括一组测量电极，一组识别电极和具有预定电阻值的电阻路径。 该组识别电极由金属材料制成，电阻路径由非金属材料制成。 该组测量电极包括彼此绝缘的参考电极和工作电极，并且该组识别电极包括通过电阻路径彼此连接的第一识别电极和第二识别电极。 绝缘层覆盖电极系统的一部分，其中未被绝缘层覆盖的电极系统的一部分与供给端口形成反应区域。 当将样品注入反应区域的供给口时，注入的样品依次到达测量电极组和识别电极组。

公开(公告)号：US20050153277A1

公开(公告)日：2005-07-14

申请号：US10849109

申请日：2004-05-18

申请人： Kai-Tsung Teng ,  Sheng-Wen Chang

发明人： Kai-Tsung Teng ,  Sheng-Wen Chang

IPC分类号： C12M1/34 ,  C12Q1/70 ,  G01N33/53

CPC分类号： G01N33/5302

摘要： An immunochemical assay device is proposed. The immunochemical assay device includes a base member, a liquid-flowing layer disposed on the base member and a light-permissible member attached on the liquid-flowing layer. A gap is interposed between the light-permissible member and the liquid-flowing layer, wherein at least an immobilized substance is disposed on the surface of the light-permissible member facing the liquid-flowing layer. The immobilized substance binds to a specific ligand-receptor complex contained in a liquid sample to form an assay marker after the liquid sample has been added into the gap. The liquid sample flows in a microfluidic environment formed between the light-permissible member and the liquid-flowing layer and reacts with the immobilized substance to produce a colored assay marker on the light-permissible member. As the light-permissible member provides better transmission of light than previously known paper materials do, the assay marker can be easily detected by human eyes.

摘要翻译： 提出了免疫化学测定装置。 免疫化学测定装置包括基底构件，设置在基底构件上的液体流动层和附着在液体流动层上的光允许构件。 在光允许部件和液体流动层之间插入有间隙，其中至少一个固定物质设置在面向液体流通层的光允许部件的表面上。 固定化物质与液体样品中包含的特定配体 - 受体复合物结合，在液体样品加入间隙后形成测定标记。 液体样品在形成在光允许构件和液体流动层之间的微流体环境中流动，并与固定化物质反应，以在光允许构件上产生着色测定标记。 由于光允许部件提供比以前已知的纸材更好的透光性，因此可以容易地通过人眼检测测定标记。

公开(公告)号：US20100252453A1

公开(公告)日：2010-10-07

申请号：US12751345

申请日：2010-03-31

申请人： Kai-Tsung TENG ,  Chien-Chuan LIN ,  Shih-Chang WANG ,  Yueh-Hui LIN ,  Thomas Y.S. SHEN

发明人： Kai-Tsung TENG ,  Chien-Chuan LIN ,  Shih-Chang WANG ,  Yueh-Hui LIN ,  Thomas Y.S. SHEN

IPC分类号： G01N27/416 ,  G01N27/26

CPC分类号： G01N27/3274

摘要： A control solution for determining the performance of an electrochemical sensing system for measuring the concentration of an analyte in a body fluid sample and methods using the same are provided. The control solution contains the analyte at a predetermined amount and an alcohol-containing adjustor. The control solution generates a current signal from the electrochemical sensing system when the performance of the electrochemical sensing system is qualified and obtains a measured concentration corresponding to the current signal, wherein the measured concentration is less than the real concentration corresponding to the predetermined amount.

摘要翻译： 提供了一种用于确定用于测量体液样品中分析物浓度的电化学感测系统的性能的控制解决方案及其使用方法。 对照溶液含有预定量的分析物和含醇的调节剂。 当电化学传感系统的性能合格并且获得对应于当前信号的测量浓度时，控制溶液从电化学感测系统产生电流信号，其中测量的浓度小于对应于预定量的实际浓度。

公开(公告)号：US08409424B2

公开(公告)日：2013-04-02

申请号：US12641406

申请日：2009-12-18

申请人： Guan-Ting Chen ,  Yueh-Hui Lin ,  Kai-Tsung Teng ,  Sz-Hau Chen ,  Thomas Y. S. Shen

发明人： Guan-Ting Chen ,  Yueh-Hui Lin ,  Kai-Tsung Teng ,  Sz-Hau Chen ,  Thomas Y. S. Shen

IPC分类号： G01N27/327

CPC分类号： G01N27/3274

摘要： An electrochemical test strip, an electrochemical test system, and a measurement method using the same are provided. The electrochemical test strip includes an insulating substrate, an electrode system formed on the insulating substrate, and an insulating layer formed on the electrode system. The electrode system includes a set of measurement electrodes, a set of identifying electrodes, and a resistive path having a predetermined resistance value. The set of identifying electrodes is made of metal material, and the resistive path is made of non-metal material. The set of measurement electrodes includes a reference electrode and a working electrode insulated from each other, and the set of identifying electrodes includes a first identifying electrode and a second identifying electrode connected with each other through the resistive path. The insulating layer covers a part of the electrode system, wherein a part of the electrode system not covered by the insulating layer forms a reaction region with a supply port. When a sample is injected into the supply port of the reaction region, the injected sample reaches the set of measurement electrodes and the set of identifying electrodes in sequence.

摘要翻译： 提供电化学测试条，电化学测试系统以及使用其的测量方法。 电化学测试条包括绝缘基板，形成在绝缘基板上的电极系统和形成在电极系统上的绝缘层。 电极系统包括一组测量电极，一组识别电极和具有预定电阻值的电阻路径。 该组识别电极由金属材料制成，电阻路径由非金属材料制成。 该组测量电极包括彼此绝缘的参考电极和工作电极，并且该组识别电极包括通过电阻路径彼此连接的第一识别电极和第二识别电极。 绝缘层覆盖电极系统的一部分，其中未被绝缘层覆盖的电极系统的一部分与供给端口形成反应区域。 当将样品注入反应区域的供给口时，注入的样品依次到达测量电极组和识别电极组。