公开(公告)号：US08382054B2

公开(公告)日：2013-02-26

申请号：US13090455

申请日：2011-04-20

申请人： Ming Chang Hsu ,  Ming Hsin Chuang ,  Mon Wen Yang ,  Thomas Y. S. Shen

发明人： Ming Chang Hsu ,  Ming Hsin Chuang ,  Mon Wen Yang ,  Thomas Y. S. Shen

IPC分类号： A47G1/10

CPC分类号： B01L9/52 ,  B01L2300/0825

摘要： A holding device comprises a first accommodation portion, a second accommodation portion, an elastic portion, and an actuating portion. The elastic portion includes a first end contacting the first accommodation portion and a second end contacting the actuating portion. The first accommodation portion includes at least one aperture. The second accommodation portion includes at least one connecting part, which passes through the aperture and connects with the actuating portion. When the actuating portion is pressed toward the first accommodation portion, a space between the first accommodation portion and the second accommodation portion expands.

摘要翻译： 保持装置包括第一容纳部分，第二容纳部分，弹性部分和致动部分。 弹性部分包括接触第一容纳部分的第一端和接触致动部分的第二端部。 第一容纳部分包括至少一个孔。 第二容纳部分包括至少一个连接部分，其穿过孔并与致动部分连接。 当致动部分朝向第一容纳部分被按压时，第一容纳部分和第二容纳部分之间的空间膨胀。

公开(公告)号：US08236154B2

公开(公告)日：2012-08-07

申请号：US12139883

申请日：2008-06-16

申请人： Sz-Hau Chen ,  Chih-Sheng Lin ,  Guan-Tin Chen ,  Yueh-Hui Lin ,  Thomas Y. S. Shen

发明人： Sz-Hau Chen ,  Chih-Sheng Lin ,  Guan-Tin Chen ,  Yueh-Hui Lin ,  Thomas Y. S. Shen

IPC分类号： G01N27/327

CPC分类号： B82Y15/00 ,  B82Y30/00 ,  G01N27/3272

摘要： The present invention provides a surface-modified electrode strip for measuring an electrochemical signal that is synergistically amplified by means of a nano-scaled gold particle layer and a lipid-soluble electron mediator layer. A biosensor comprising the electrode strip is also provided.

摘要翻译： 本发明提供一种用于测量电化学信号的表面改性电极条，其通过纳米级金颗粒层和脂溶性电子介体层协同放大。 还提供了包括电极条的生物传感器。

公开(公告)号：US20110104731A1

公开(公告)日：2011-05-05

申请号：US12832030

申请日：2010-07-07

申请人： Kai Tsung TENG ,  Yueh-Hui LIN ,  Thomas Y. S. SHEN

发明人： Kai Tsung TENG ,  Yueh-Hui LIN ,  Thomas Y. S. SHEN

IPC分类号： C12M1/10 ,  C12Q1/02

CPC分类号： B01L3/502 ,  B01L2200/0621 ,  B01L2300/0809 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N2035/0429

摘要： A reaction cassette for biochemical assay, a biochemical assay device including the reaction cassette, and a biochemical assay method performed by using the biochemical assay device are provided. The reaction cassette includes a first space, a second space, a third space, and an inner wall. The first space is configured to accommodate liquid and includes a first opening facing upward. The second space includes a second opening whose direction is perpendicular to the direction of the first opening. The first space and the second space are disposed such that when the reaction cassette is rotated, liquid in the first space can flow into the second space. The third space is located under the first space and includes a third opening whose direction is the same as the direction of the first opening. The inner wall connects the second opening and the third opening, which serves as a liquid flow channel between the second space and the third space.

摘要翻译： 提供了用于生物化学测定的反应盒，包括该反应盒的生物化学测定装置以及通过使用该生化测定装置进行的生物化学测定方法。 反应盒包括第一空间，第二空间，第三空间和内壁。 第一空间构造成容纳液体并且包括面向上的第一开口。 第二空间包括其方向垂直于第一开口的方向的第二开口。 第一空间和第二空间被布置成使得当反应盒旋转时，第一空间中的液体可以流入第二空间。 第三空间位于第一空间的下方，具有与第一开口方向相同的第三开口。 内壁连接第二开口和第三开口，其作为在第二空间和第三空间之间的液体流动通道。

公开(公告)号：US20100089775A1

公开(公告)日：2010-04-15

申请号：US12641406

申请日：2009-12-18

申请人： Guan-Ting CHEN ,  Yueh-Hui Lin ,  Kai-Tsung Teng ,  Sz-Hau Chen ,  Thomas Y. S. Shen

发明人： Guan-Ting CHEN ,  Yueh-Hui Lin ,  Kai-Tsung Teng ,  Sz-Hau Chen ,  Thomas Y. S. Shen

IPC分类号： G01N27/26

CPC分类号： G01N27/3274

摘要： An electrochemical test strip, an electrochemical test system, and a measurement method using the same are provided. The electrochemical test strip includes an insulating substrate, an electrode system formed on the insulating substrate, and an insulating layer formed on the electrode system. The electrode system includes a set of measurement electrodes, a set of identifying electrodes, and a resistive path having a predetermined resistance value. The set of identifying electrodes is made of metal material, and the resistive path is made of non-metal material. The set of measurement electrodes includes a reference electrode and a working electrode insulated from each other, and the set of identifying electrodes includes a first identifying electrode and a second identifying electrode connected with each other through the resistive path. The insulating layer covers a part of the electrode system, wherein a part of the electrode system not covered by the insulating layer forms a reaction region with a supply port. When a sample is injected into the supply port of the reaction region, the injected sample reaches the set of measurement electrodes and the set of identifying electrodes in sequence.

摘要翻译： 提供电化学测试条，电化学测试系统以及使用其的测量方法。 电化学测试条包括绝缘基板，形成在绝缘基板上的电极系统和形成在电极系统上的绝缘层。 电极系统包括一组测量电极，一组识别电极和具有预定电阻值的电阻路径。 该组识别电极由金属材料制成，电阻路径由非金属材料制成。 该组测量电极包括彼此绝缘的参考电极和工作电极，并且该组识别电极包括通过电阻路径彼此连接的第一识别电极和第二识别电极。 绝缘层覆盖电极系统的一部分，其中未被绝缘层覆盖的电极系统的一部分与供给端口形成反应区域。 当将样品注入反应区域的供给口时，注入的样品依次到达测量电极组和识别电极组。

公开(公告)号：US08728407B2

公开(公告)日：2014-05-20

申请号：US13620728

申请日：2012-09-15

申请人： Ming-Chang Hsu ,  Ming-Hsin Chuang ,  Mon-Wen Yang ,  Thomas Y. S. Shen

发明人： Ming-Chang Hsu ,  Ming-Hsin Chuang ,  Mon-Wen Yang ,  Thomas Y. S. Shen

IPC分类号： G01N33/00

CPC分类号： A61B5/145 ,  A61B2562/0295 ,  G01N33/4875

摘要： A holding device disposed in a bio-detecting instrument for holding a test strip is provided, wherein the holding device comprises a first casing, a second casing, an ejecting member, and an elastic member. The second casing is assembled with the first casing to form an accommodating space, wherein the sensing terminals are extended into the accommodating space. The ejecting member comprises a push rod configured to be reciprocated in the accommodating space. The elastic member is configured to be compressed by driving the ejecting member to an ejecting position, where the push rod enters the accommodating space and is adapted to push the test strip outward without being contact with the sensing terminals, and the elastic member is configured to be released by drawing the push rod back from the accommodating space to an initial position.

摘要翻译： 设置在用于保持测试条的生物检测仪器中的保持装置，其中保持装置包括第一壳体，第二壳体，排出构件和弹性构件。 第二壳体与第一壳体组装以形成容纳空间，其中感测端子延伸到容纳空间中。 排出构件包括构造成在容纳空间中往复运动的推杆。 弹性构件被构造成通过将排出构件驱动到排出位置而被压缩，其中推杆进入容纳空间，并且适于将测试条向外推动而不与感测端接触，并且弹性构件被配置为 通过将推杆从容纳空间拉回到初始位置而被释放。

公开(公告)号：US08524168B2

公开(公告)日：2013-09-03

申请号：US12816281

申请日：2010-06-15

申请人： Ming-Chang Hsu ,  Mon Wen Yang ,  Ming-Hsin Chuang ,  Thomas Y. S. Shen

发明人： Ming-Chang Hsu ,  Mon Wen Yang ,  Ming-Hsin Chuang ,  Thomas Y. S. Shen

IPC分类号： G01N33/00

CPC分类号： G01N33/4875

摘要： A device for holding a medical test strip is provided. The device comprises a receiving casing having an opening for receiving the medical test strip and a first stopping portion protruding from an upper surface of the receiving casing; an ejection base having a cover and a pusher beneath the cover, the cover downwardly extending a second stopping portion for sliding against the upper surface of the receiving casing; and an elastic member located between the receiving casing and the ejection base. When the pusher moves toward the opening by an external force to eject the test strip from the opening, the elastic member is compressed and the second stopping portion slides away from the first stopping portion. When the external force disappears, the second stopping portion slides toward the first stopping portion by a resilient force of the elastic member until the first stopping portion and the second stopping portion are engaged.

摘要翻译： 提供了一种用于保持医用测试条的装置。 该装置包括：接收壳体，具有用于容纳医用测试条的开口和从接收壳体的上表面突出的第一止动部分; 具有盖和推动器的喷射基座，所述盖在所述盖下方延伸，所述第二止动部向下延伸以抵靠所述接收壳体的上表面滑动; 以及位于接收壳体和喷射基座之间的弹性构件。 当推动器通过外力朝向开口移动以从开口弹出测试条时，弹性构件被压缩，并且第二止动部分从第一止动部分滑离。 当外力消失时，第二止动部通过弹性部件的弹力向第一止动部滑动，直到第一止动部和第二止动部接合。

公开(公告)号：US07384659B2

公开(公告)日：2008-06-10

申请号：US10401035

申请日：2003-03-28

申请人： Yueh-Hui Lin ,  Thomas Y. S. Shen

发明人： Yueh-Hui Lin ,  Thomas Y. S. Shen

IPC分类号： B05D5/12

CPC分类号： G01N33/49

摘要： The present invention relates to a method of producing a non-enzymatic whole blood uric acid detecting electrode strip for use on whole blood, characterized by comprising the step of adding dropwise a reaction film formulation onto the electrochemical reaction zone wherein the formulation comprises an electron mediator, a water-soluble polymer carrier and a volatile organic solvent.

摘要翻译： 本发明涉及一种生产全血用非酶全血尿酸检测电极条的方法，其特征在于包括将反应膜制剂滴加到电化学反应区上的步骤，其中制剂包含电子介体 ，水溶性聚合物载体和挥发性有机溶剂。

公开(公告)号：US08512532B2

公开(公告)日：2013-08-20

申请号：US12035231

申请日：2008-02-21

申请人： Yueh-Hui Lin ,  Thomas Y. S. Shen

发明人： Yueh-Hui Lin ,  Thomas Y. S. Shen

IPC分类号： G01N27/327

CPC分类号： G01N33/49

摘要： The present invention relates to a reaction film formulation used in the preparation of a non-enzymatic whole blood uric acid detecting electrode strip, which comprises an electron mediator, a water-soluble polymer carrier, and a volatile organic solvent, and to whole blood biosensor systems.

摘要翻译： 本发明涉及用于制备非酶全血尿酸检测电极条的反应膜制剂，其包含电子介体，水溶性聚合物载体和挥发性有机溶剂，以及全血生物传感器 系统。

公开(公告)号：US06491803B1

公开(公告)日：2002-12-10

申请号：US09859371

申请日：2001-05-18

申请人： Thomas Y. S. Shen ,  Wen-Chang Chen ,  Hong-Ming Lin ,  Jen-Hung Chuang

发明人： Thomas Y. S. Shen ,  Wen-Chang Chen ,  Hong-Ming Lin ,  Jen-Hung Chuang

IPC分类号： G01N27327

CPC分类号： G01N33/5438 ,  G01N27/3272 ,  G01N2333/904

摘要： The present invention relates to a test strip and a biosensor having an increased conductivity and a slurry comprising a fiber, meal particles having a size in nanometer and a bioactive substance. The invention is characterized by incorporating metal particles having size in nanometer into the reaction layer of test strip and biosensor to increase the conductivity between the reaction layer and the electrodes so that the redox reaction can be readily completed and the measurement time can thus be shortened.

摘要翻译： 本发明涉及具有增加的导电性的测试条和生物传感器以及包含纤维，具有纳米尺寸的粕颗粒和生物活性物质的浆料。 本发明的特征在于将具有纳米尺寸的金属颗粒结合到测试条的反应层和生物传感器中以增加反应层与电极之间的导电性，从而可以容易地完成氧化还原反应，从而缩短测量时间。

公开(公告)号：US08409424B2

公开(公告)日：2013-04-02

申请号：US12641406

申请日：2009-12-18

申请人： Guan-Ting Chen ,  Yueh-Hui Lin ,  Kai-Tsung Teng ,  Sz-Hau Chen ,  Thomas Y. S. Shen

发明人： Guan-Ting Chen ,  Yueh-Hui Lin ,  Kai-Tsung Teng ,  Sz-Hau Chen ,  Thomas Y. S. Shen

IPC分类号： G01N27/327

CPC分类号： G01N27/3274

摘要： An electrochemical test strip, an electrochemical test system, and a measurement method using the same are provided. The electrochemical test strip includes an insulating substrate, an electrode system formed on the insulating substrate, and an insulating layer formed on the electrode system. The electrode system includes a set of measurement electrodes, a set of identifying electrodes, and a resistive path having a predetermined resistance value. The set of identifying electrodes is made of metal material, and the resistive path is made of non-metal material. The set of measurement electrodes includes a reference electrode and a working electrode insulated from each other, and the set of identifying electrodes includes a first identifying electrode and a second identifying electrode connected with each other through the resistive path. The insulating layer covers a part of the electrode system, wherein a part of the electrode system not covered by the insulating layer forms a reaction region with a supply port. When a sample is injected into the supply port of the reaction region, the injected sample reaches the set of measurement electrodes and the set of identifying electrodes in sequence.

摘要翻译： 提供电化学测试条，电化学测试系统以及使用其的测量方法。 电化学测试条包括绝缘基板，形成在绝缘基板上的电极系统和形成在电极系统上的绝缘层。 电极系统包括一组测量电极，一组识别电极和具有预定电阻值的电阻路径。 该组识别电极由金属材料制成，电阻路径由非金属材料制成。 该组测量电极包括彼此绝缘的参考电极和工作电极，并且该组识别电极包括通过电阻路径彼此连接的第一识别电极和第二识别电极。 绝缘层覆盖电极系统的一部分，其中未被绝缘层覆盖的电极系统的一部分与供给端口形成反应区域。 当将样品注入反应区域的供给口时，注入的样品依次到达测量电极组和识别电极组。