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公开(公告)号：US20080181889A1
公开(公告)日：2008-07-31
申请号：US11868788
申请日：2007-10-08
IPC分类号： A61K39/395 , A61K38/02 , A61K31/7052 , A61K38/16 , A61K38/10 , G01N33/53 , C12N5/00 , C07K16/00
CPC分类号： C07K16/125 , C07K2317/622 , C07K2317/76
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The compositions include EMP2 nucleic acids and polypeptides as well as anti-EMP2 antibodies.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染的方法和组合物。 方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 组合物包括EMP2核酸和多肽以及抗EMP2抗体。
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公开(公告)号：US08648052B2
公开(公告)日：2014-02-11
申请号：US11868788
申请日：2007-10-08
IPC分类号： C12N15/11 , A61K39/118
CPC分类号： C07K16/125 , C07K2317/622 , C07K2317/76
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The compositions include EMP2 nucleic acids and polypeptides as well as anti-EMP2 antibodies.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染的方法和组合物。 方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 组合物包括EMP2核酸和多肽以及抗EMP2抗体。
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公开(公告)号：US20120020983A9
公开(公告)日：2012-01-26
申请号：US12682032
申请日：2008-10-08
申请人： Jonathan Braun , Lynn K. Gordon , Kaori Shimazaki , Madhuri Wadehra , Kathy A. Kelly , Anna M. Wu
发明人： Jonathan Braun , Lynn K. Gordon , Kaori Shimazaki , Madhuri Wadehra , Kathy A. Kelly , Anna M. Wu
IPC分类号： A61K39/395 , G01N33/53 , A61P35/00 , C07K16/18
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , C07K16/125 , C07K16/28 , C07K2316/96 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染和癌症的方法和组合物。 方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 方法和组合物靶向通过靶向EMP2表达或过表达EMP2核酸和多肽的癌症。
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公开(公告)号：US20100272732A1
公开(公告)日：2010-10-28
申请号：US12682032
申请日：2008-10-08
申请人： Jonathan Braun , Lynn K. Gordon , Kaori Shimazaki , Madhuri Wadehra , Kathy A. Kelly , Anna M. Wu
发明人： Jonathan Braun , Lynn K. Gordon , Kaori Shimazaki , Madhuri Wadehra , Kathy A. Kelly , Anna M. Wu
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53 , A61P35/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , C07K16/125 , C07K16/28 , C07K2316/96 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染和癌症的方法和组合物。 该方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 方法和组合物靶向通过靶向EMP2表达或过表达EMP2核酸和多肽的癌症。
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