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公开(公告)号：US08648052B2
公开(公告)日：2014-02-11
申请号：US11868788
申请日：2007-10-08
IPC分类号： C12N15/11 , A61K39/118
CPC分类号： C07K16/125 , C07K2317/622 , C07K2317/76
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The compositions include EMP2 nucleic acids and polypeptides as well as anti-EMP2 antibodies.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染的方法和组合物。 方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 组合物包括EMP2核酸和多肽以及抗EMP2抗体。
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公开(公告)号：US20080181889A1
公开(公告)日：2008-07-31
申请号：US11868788
申请日：2007-10-08
IPC分类号： A61K39/395 , A61K38/02 , A61K31/7052 , A61K38/16 , A61K38/10 , G01N33/53 , C12N5/00 , C07K16/00
CPC分类号： C07K16/125 , C07K2317/622 , C07K2317/76
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The compositions include EMP2 nucleic acids and polypeptides as well as anti-EMP2 antibodies.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染的方法和组合物。 方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 组合物包括EMP2核酸和多肽以及抗EMP2抗体。
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公开(公告)号：US20120020983A9
公开(公告)日：2012-01-26
申请号：US12682032
申请日：2008-10-08
申请人： Jonathan Braun , Lynn K. Gordon , Kaori Shimazaki , Madhuri Wadehra , Kathy A. Kelly , Anna M. Wu
发明人： Jonathan Braun , Lynn K. Gordon , Kaori Shimazaki , Madhuri Wadehra , Kathy A. Kelly , Anna M. Wu
IPC分类号： A61K39/395 , G01N33/53 , A61P35/00 , C07K16/18
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , C07K16/125 , C07K16/28 , C07K2316/96 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染和癌症的方法和组合物。 方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 方法和组合物靶向通过靶向EMP2表达或过表达EMP2核酸和多肽的癌症。
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公开(公告)号：US20100272732A1
公开(公告)日：2010-10-28
申请号：US12682032
申请日：2008-10-08
申请人： Jonathan Braun , Lynn K. Gordon , Kaori Shimazaki , Madhuri Wadehra , Kathy A. Kelly , Anna M. Wu
发明人： Jonathan Braun , Lynn K. Gordon , Kaori Shimazaki , Madhuri Wadehra , Kathy A. Kelly , Anna M. Wu
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53 , A61P35/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , C07K16/125 , C07K16/28 , C07K2316/96 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染和癌症的方法和组合物。 该方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 方法和组合物靶向通过靶向EMP2表达或过表达EMP2核酸和多肽的癌症。
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公开(公告)号：US08318906B2
公开(公告)日：2012-11-27
申请号：US12682032
申请日：2008-10-08
申请人： Jonathan Braun , Lynn K. Gordon , Kaori Shimizaki , Madhuri Wadegra-Dhawan , Kathy A. Kelly , Anna M. Wu
发明人： Jonathan Braun , Lynn K. Gordon , Kaori Shimizaki , Madhuri Wadegra-Dhawan , Kathy A. Kelly , Anna M. Wu
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , G01N33/566
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , C07K16/125 , C07K16/28 , C07K2316/96 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染和癌症的方法和组合物。 方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 方法和组合物靶向通过靶向EMP2表达或过表达EMP2核酸和多肽的癌症。
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6.发明授权Epithelial membrane protein-2 (EMP2) and proliferative vitroretinopathy (PVR) 有权上皮膜蛋白-2（EMP2）和增殖性视网膜病变（PVR）公开(公告)号：US09464135B2
公开(公告)日：2016-10-11
申请号：US13510877
申请日：2010-11-18
CPC分类号： C07K16/28 , A61K9/0048 , A61K9/0051 , A61K2039/505
摘要： Methods of preventing retinal detachment associated with proliferative vitreoretinopathy are provided by administering agents which antagonize the activity or function of EMP2 to subjects at risk of the detachment.
摘要翻译： 防止与增殖性玻璃体视网膜病变相关的视网膜脱离的方法是通过将拮抗EMP2的活性或功能的给药剂施用于具有脱离风险的受试者来提供的。
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7.发明申请EPITHELIAL MEMBRANE PROTEIN 2 (EMP2) BINDING REAGENTS AND THEIR THERAPEUTIC USES IN OCULAR DISEASES 审中-公开上皮蛋白2（EMP2）结合试剂及其在眼部疾病中的治疗用途公开(公告)号：US20130034555A1
公开(公告)日：2013-02-07
申请号：US13580100
申请日：2011-02-22
IPC分类号： A61K39/395 , A61P27/02 , A61K31/7088
CPC分类号： C07K16/18 , A61K38/00 , C07K16/28 , C07K2317/21 , C07K2317/35 , C07K2317/76 , C12N15/1138 , C12N2310/14
摘要： A method is disclosed for treating diseases or disorders of the eye involving undesired expression of vascular endothelial growth factor (VEGF) by administration of endothelial membrane protein 2 (EMP2) inhibitor. The present invention relates to the direct treatment of macular degeneration, particularly age-related macular degeneration (AMD), by administering an EMP2 inhibitor intraocularly or systemically.
摘要翻译： 公开了一种通过施用内皮细胞膜蛋白2（EMP2）抑制剂治疗涉及血管内皮生长因子（VEGF）不希望的表达的疾病或病症的方法。 本发明涉及通过在眼内或全身施用EMP2抑制剂来直接治疗黄斑变性，特别是年龄相关性黄斑变性（AMD）。
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8.发明申请EPITHELIAL MEMBRANE PROTEIN-2 (EMP2) AND PROLIFERATIVE VITRORETINOPATHY (PVR) 有权上皮膜蛋白-2（EMP2）和增殖性VITRORETINOPATHY（PVR）公开(公告)号：US20130004493A1
公开(公告)日：2013-01-03
申请号：US13510877
申请日：2010-11-18
IPC分类号： A61K39/395 , C12N5/079 , A61P27/02
CPC分类号： C07K16/28 , A61K9/0048 , A61K9/0051 , A61K2039/505
摘要： Methods of preventing retinal detachment associated with proliferative vitreoretinopathy are provided by administering agents which antagonize the activity or function of EMP2 to subjects at risk of the detachment.
摘要翻译： 防止与增殖性玻璃体视网膜病变相关的视网膜脱离的方法是通过将拮抗EMP2的活性或功能的给药剂施用于具有脱离风险的受试者来提供的。
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9.发明授权Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen 有权使用OmpC抗原诊断，预防和治疗克罗恩病公开(公告)号：US07993865B2
公开(公告)日：2011-08-09
申请号：US11561024
申请日：2006-11-17
IPC分类号： G01N33/564 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在或IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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公开(公告)号：US20100196509A1
公开(公告)日：2010-08-05
申请号：US11884806
申请日：2006-02-28
IPC分类号： A61K33/24 , C12Q1/68 , G01N33/53 , A61K31/4355 , A61K31/56 , A61K31/7088 , A61P35/00
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57442 , G01N2500/02 , G01N2500/10
摘要： The present invention discloses methods of using endothelial membrane protein 2 (EMP2) as a biomarker for stratification of endometrial premalignancy, diagnosing, staging and imaging of endometrial neoplasia. Further, methods for identifying pharmaceutical/therapeutic modalities are described, including compositions which modulate glycolipid-enriched lipid raft microdomains (GEMs).
摘要翻译： 本发明公开了使用内皮膜蛋白2（EMP2）作为子宫内膜癌前期分期，诊断，分期和成像子宫内膜瘤形成的生物标志物的方法。 此外，描述了用于鉴定药物/治疗方式的方法，包括调节富含糖脂的脂筏微结构域（GEM））的组合物。
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