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公开(公告)号：US07959917B2
公开(公告)日：2011-06-14
申请号：US12032061
申请日：2008-02-15
Applicant: Duncan Cochrane , Suzanne Cohen , Claire Louise Dobson , Per-Olof Eriksson , Karin Von Wachenfeldt , Phillip David Monk
Inventor： Duncan Cochrane , Suzanne Cohen , Claire Louise Dobson , Per-Olof Eriksson , Karin Von Wachenfeldt , Phillip David Monk
IPC: A61K39/00
CPC classification number: C07K16/4291 , A61K2039/505 , C07K14/70535 , C07K16/26 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00 , Y10S424/805 , Y10S424/81 , Y10S530/862
Abstract: This invention relates to binding members, especially antibody molecules, for IgE. The binding members are useful for, inter alia, treatment of disorders mediated by IgE including allergies and asthma.
Abstract translation: 本发明涉及IgE的结合成员，特别是抗体分子。 结合成员尤其可用于治疗由IgE介导的疾病，包括过敏和哮喘。
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公开(公告)号：US08389704B2
公开(公告)日：2013-03-05
申请号：US12527169
申请日：2008-02-15
Applicant: Duncan Cochrane , Suzanne Cohen , Louise Claire Dobson , Fredick Per-Olof Eriksson , David Phillip Monk , Karin Von-Wachenfeldt
Inventor： Duncan Cochrane , Suzanne Cohen , Louise Claire Dobson , Fredick Per-Olof Eriksson , David Phillip Monk , Karin Von-Wachenfeldt
IPC: C07H21/04
CPC classification number: C07K16/4291 , A61K2039/505 , C07K14/70535 , C07K16/26 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00 , Y10S424/805 , Y10S424/81 , Y10S530/862
Abstract: This invention relates to binding members, especially antibody molecules, for IgE. The binding members are useful for, inter alia, treatment of disorders mediated by IgE including allergies and asthma.
Abstract translation: 本发明涉及IgE的结合成员，特别是抗体分子。 结合成员尤其可用于治疗由IgE介导的疾病，包括过敏和哮喘。
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3.发明申请公开(公告)号：US20120171197A1
公开(公告)日：2012-07-05
申请号：US13311715
申请日：2011-12-06
Applicant: PER-OLOF FREDRIK ERIKSSON , KARIN VON WACHENFELDT , SUZANNE COHEN , CLAIRE LOUISE DOBSON , DEBORAH LOUISE LANE
Inventor： PER-OLOF FREDRIK ERIKSSON , KARIN VON WACHENFELDT , SUZANNE COHEN , CLAIRE LOUISE DOBSON , DEBORAH LOUISE LANE
CPC classification number: C07K16/2866 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
Abstract: Binding members, especially antibody molecules, for interleukin (IL)-4 receptor alpha (IL-4Rα), and their therapeutic use e.g. in treating or preventing disorders associated with IL-4Rα, IL-4 and/or IL-13, examples of which are asthma and COPD.
Abstract translation: 用于白细胞介素（IL）-4受体α（IL-4Rα）的结合成员，特别是抗体分子，以及它们的治疗用途。 在治疗或预防与IL-4Rα，IL-4和/或IL-13相关的疾病中，其实例是哮喘和COPD。
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4.发明授权公开(公告)号：US08092804B2
公开(公告)日：2012-01-10
申请号：US12338161
申请日：2008-12-18
Applicant: Per-Olof Fredrik Eriksson , Karin Von Wachenfeldt , Suzanne Cohen , Claire Louise Dobson , Deborah Louise Lane
Inventor： Per-Olof Fredrik Eriksson , Karin Von Wachenfeldt , Suzanne Cohen , Claire Louise Dobson , Deborah Louise Lane
IPC: A61K39/395 , C07K16/00 , C07K16/18 , C07K16/28 , C12N15/13
CPC classification number: C07K16/2866 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
Abstract: Binding members, especially antibody molecules, for interleukin (IL)-4 receptor alpha (IL-4Rα), and their therapeutic use e.g. in treating or preventing disorders associated with IL-4Rα, IL-4 and/or IL-13, examples of which are asthma and COPD.
Abstract translation: 用于白细胞介素（IL）-4受体α（IL-4Rα）的结合成员，特别是抗体分子，以及它们的治疗用途。 在治疗或预防与IL-4Rα，IL-4和/或IL-13相关的疾病中，其实例是哮喘和COPD。
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Patent Agency Ranking
公开(公告)号：US20100021940A1
公开(公告)日：2010-01-28
申请号：US12296568
申请日：2007-04-11
Applicant: Anders Blomgren , Anders Eriksson , Thomas Hansson , Keith Jolley , Matti Lepisto , Karin Von Wachenfeldt
Inventor： Anders Blomgren , Anders Eriksson , Thomas Hansson , Keith Jolley , Matti Lepisto , Karin Von Wachenfeldt
IPC: C12Q1/37 , G01N33/573 , C07K2/00 , C07C205/00
CPC classification number: C12Q1/37 , G01N2333/96486 , G01N2500/00 , G01N2800/122
Abstract: There is provided a method for determining the activity of a protease in a sample. The method comprises (i) admixing said sample with a substrate, wherein the substrate has the formula (1a) wherein: R1 is a hydrocarbyl group; R2 is a first peptide moiety; R3 is a second peptide moiety and X is selected from the group consisting of O, S and NH; Y1 is a suitable substituent; Y2 is a suitable substituent; and (ii) determining the activity of said protease by detecting the presence of a reporter having the formula H—X—R1, wherein: X is selected from the group consisting of O, S and NH; R1 is a hydrocarbyl group. The substrate and reporter are useful for determining the efficacy of protease-modulators and candidate protease-modulators and in the diagnosis of a disease or disorder in a subject.
Abstract translation: 提供了测定样品中蛋白酶活性的方法。 该方法包括（i）将所述样品与基底混合，其中基底具有式（1a），其中：R1是烃基; R2是第一个肽部分; R3是第二肽部分，X选自O，S和NH; Y1是合适的取代基; Y2是合适的取代基; 和（ii）通过检测存在具有式H-X-R1的报告基来确定所述蛋白酶的活性，其中：X选自O，S和NH; R1是烃基。 底物和报告物可用于确定蛋白酶调节剂和候选蛋白酶调节剂的功效以及受试者中疾病或病症的诊断。
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公开(公告)号：US20110212084A1
公开(公告)日：2011-09-01
申请号：US12527135
申请日：2008-02-15
Applicant: Duncan Cochrane , Suzanne Cohen , Louise Claire Dobson , Fredick Per-Olof Eriksson , David Phillip Monk , Karin Von-Wachenfeldt
Inventor： Duncan Cochrane , Suzanne Cohen , Louise Claire Dobson , Fredick Per-Olof Eriksson , David Phillip Monk , Karin Von-Wachenfeldt
IPC: A61K39/395 , C12N5/10 , C12N1/00 , C07K16/42 , C12P21/02 , C07H21/00 , A61P37/08 , A61P11/06 , A61P29/00 , A61P27/14
CPC classification number: C07K16/4291 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: This invention relates to binding members, especially antibody molecules, for IgE. The binding members are useful for, inter alia, treatment of disorders mediated by IgE including allergies and asthma.
Abstract translation: 本发明涉及IgE的结合成员，特别是抗体分子。 结合成员尤其可用于治疗由IgE介导的疾病，包括过敏和哮喘。
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公开(公告)号：US20100150904A1
公开(公告)日：2010-06-17
申请号：US12527169
申请日：2008-02-15
Applicant: Duncan Cochrane , Suzanne Cohen , Louise Claire Dobson , Fredick Per-Olof Eriksson , David Phillip Monk , Karin Von-Wachenfeldt
Inventor： Duncan Cochrane , Suzanne Cohen , Louise Claire Dobson , Fredick Per-Olof Eriksson , David Phillip Monk , Karin Von-Wachenfeldt
CPC classification number: C07K16/4291 , A61K2039/505 , C07K14/70535 , C07K16/26 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00 , Y10S424/805 , Y10S424/81 , Y10S530/862
Abstract: This invention relates to binding members, especially antibody molecules, for IgE. The binding members are useful for, inter alia, treatment of disorders mediated by IgE including allergies and asthma.
Abstract translation: 本发明涉及IgE的结合成员，特别是抗体分子。 结合成员尤其可用于治疗由IgE介导的疾病，包括过敏和哮喘。
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8.发明申请公开(公告)号：US20090202568A1
公开(公告)日：2009-08-13
申请号：US12338161
申请日：2008-12-18
Applicant: Per-Olof Fredrik Eriksson , Karin Von Wachenfeldt , Suzanne Cohen , Claire Louise Dobson , Deborah Louise Lane
Inventor： Per-Olof Fredrik Eriksson , Karin Von Wachenfeldt , Suzanne Cohen , Claire Louise Dobson , Deborah Louise Lane
IPC: A61K39/395 , A61P11/06 , C07K16/28 , C07H21/00 , C12N5/10
CPC classification number: C07K16/2866 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
Abstract: Binding members, especially antibody molecules, for interleukin (IL)-4 receptor alpha (IL-4Rα), and their therapeutic use e.g. in treating or preventing disorders associated with IL-4Rα, IL-4 and/or IL-13, examples of which are asthma and COPD.
Abstract translation: 用于白细胞介素（IL）-4受体α（IL-4Ralpha）的结合成员，特别是抗体分子，以及它们的治疗用途。 在治疗或预防与IL-4Ralpha，IL-4和/或IL-13相关的疾病中，其实例是哮喘和COPD。
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公开(公告)号：US20090060919A1
公开(公告)日：2009-03-05
申请号：US12032061
申请日：2008-02-15
Applicant: Duncan Cochrane , Suzanne Cohen , Claire Louise Dobson , Per-Olof Eriksson , Karin Von Wachenfeldt , Phillip David Monk
Inventor： Duncan Cochrane , Suzanne Cohen , Claire Louise Dobson , Per-Olof Eriksson , Karin Von Wachenfeldt , Phillip David Monk
CPC classification number: C07K16/4291 , A61K2039/505 , C07K14/70535 , C07K16/26 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00 , Y10S424/805 , Y10S424/81 , Y10S530/862
Abstract: This invention relates to binding members, especially antibody molecules, for IgE. The binding members are useful for, inter alia, treatment of disorders mediated by IgE including allergies and asthma.
Abstract translation: 本发明涉及IgE的结合成员，特别是抗体分子。 结合成员尤其可用于治疗由IgE介导的疾病，包括过敏和哮喘。
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