公开(公告)号：US4065568A

公开(公告)日：1977-12-27

申请号：US634913

申请日：1975-11-24

Applicant: Karl Heinrich Mayer ,  Friedrich Hoffmeister ,  Wolfgang Wuttke

Inventor： Karl Heinrich Mayer ,  Friedrich Hoffmeister ,  Wolfgang Wuttke

IPC: C07D231/56 ,  A61K31/415

CPC classification number: C07D231/56 ,  Y10S514/916

Abstract: 3-Hydrazinoindazoles acylated with a carbo(lower alkoxy) group in the 3-position and further being optionally substituted in one or more of the 4-, 5-, 6- and/or 7-positions are analgesic, anti-inflammatory and antipyretic agents. The compounds, of which 3-carbomethoxyhydrazino-6-chloroindazole is a typical embodiment, are prepared through treatment of the appropriate 3-hydrazinoindazole with a derivative of carbonic acid.

Abstract translation: 在3-位上被碳（低级烷氧基）基团酰化并且进一步任选在一个或多个4-，5-，6-和/或7-位被取代的3-肼基吲唑是止痛，抗炎和解热 代理商 通过用碳酸衍生物处理合适的3-肼基吲唑，制备3-甲酯基肼基-6-氯吲唑是其典型实施方案的化合物。

公开(公告)号：US3995044A

公开(公告)日：1976-11-30

申请号：US583464

申请日：1975-06-03

Applicant: Hans-Joachim Kabbe ,  Hinrich Otten ,  Karl Heinrich Mayer ,  Erich Klauke

Inventor： Hans-Joachim Kabbe ,  Hinrich Otten ,  Karl Heinrich Mayer ,  Erich Klauke

IPC: C07D207/32 ,  C07D207/325 ,  C07D207/335 ,  C07D209/14 ,  C07D209/16 ,  C07D213/40 ,  C07D215/10 ,  C07D215/12 ,  C07D217/02 ,  C07D217/14 ,  C07D231/56 ,  C07D235/14 ,  C07D239/26 ,  C07D249/04 ,  C07D277/28 ,  C07D307/14 ,  C07D307/52 ,  C07D309/20 ,  A61K31/44

CPC classification number: C07D309/20 ,  C07D207/32 ,  C07D207/335 ,  C07D209/14 ,  C07D209/16 ,  C07D213/40 ,  C07D215/12 ,  C07D217/14 ,  C07D231/56 ,  C07D235/14 ,  C07D239/26 ,  C07D249/04 ,  C07D277/28 ,  C07D307/14 ,  C07D307/52

Abstract: Benzoic acid amides characterized by the presence of a nitro, cyano, trifluoromethyl, alkylsulfonyl, carboxy, carbalkoxy, amido or sulfonamido substituent in the phenyl ring and by the presence of a heterocyclic group connected to the amide nitrogen atom through a hydrocarbon chain are antibacterial agents and in particular antituberculosis agents. The compounds, of which N-(pyrid-2-yl-methyl)3,5-dinitrobenzoic acid amide is a typical embodiment, are prepared by the reaction of an appropriately substituted benzoic acid, or derivative thereof, with an appropriate amine.

Abstract translation: 特征在于苯环中存在硝基，氰基，三氟甲基，烷基磺酰基，羧基，烷氧基，酰氨基或亚磺酰氨基取代基的苯甲酸酰胺和通过烃链与酰胺氮原子连接的杂环基的存在是抗菌剂 特别是抗结核药物。 通过使适当取代的苯甲酸或其衍生物与适当的胺反应，制备其N-（吡啶-2-基 - 甲基）3,5-二硝基苯甲酸酰胺的化合物是典型的实施方案。

公开(公告)号：US4051252A

公开(公告)日：1977-09-27

申请号：US634914

申请日：1975-11-24

Applicant: Karl Heinrich Mayer ,  Siegfried Petersen ,  Erich Klauke ,  Friedrich Hoffmeister ,  Wolfgang Wuttke

Inventor： Karl Heinrich Mayer ,  Siegfried Petersen ,  Erich Klauke ,  Friedrich Hoffmeister ,  Wolfgang Wuttke

IPC: C07D231/56 ,  A61K31/415

CPC classification number: C07D231/56 ,  Y10S514/916

Abstract: 3-Aminoindazoles bearing a carbo(lower alkoxy), lower alkylamide or di(lower alkyl)amide group in the 1-or 2-position and further being optionally substituted in one or more of the 4-, 5-, 6- and/or 7-positions are analgesic, anti-inflammatory and antipyretic agents. The compounds, of which 3-amino-6-chloroindazole-1-carboxylic acid ethyl ester is a typical embodiment, are prepared through treatment of the appropriate 3-aminoindazole with a derivative of carbonic acid or through thermal isomerization.

公开(公告)号：US4006239A

公开(公告)日：1977-02-01

申请号：US564224

申请日：1975-04-02

Applicant: Karl Heinrich Mayer ,  Hans-Joachim Kabbe ,  Hinrich Otten

Inventor： Karl Heinrich Mayer ,  Hans-Joachim Kabbe ,  Hinrich Otten

IPC: C07D207/32 ,  C07D207/325 ,  C07D213/40 ,  C07D215/12 ,  C07D217/14 ,  C07D231/56 ,  C07D239/26 ,  C07D241/12 ,  C07D307/14 ,  C07D309/20 ,  C07D401/12 ,  A61K31/44

CPC classification number: C07D309/20 ,  C07D207/32 ,  C07D207/325 ,  C07D213/40 ,  C07D215/12 ,  C07D217/14 ,  C07D231/56 ,  C07D239/26 ,  C07D241/12 ,  C07D307/14

Abstract: Benzoic acid amides characterized by the presence of a hydroxy or amino substituent in the phenyl ring, or an alkylated or acylated derivative thereof and by a heterocyclic group connected to the amide nitrogen atom through a hydrocarbon chain are antibacterial agents and in particular anti-tuberculosis agents. The compounds, of which N-[pyridyl-(2)-methyl]-2-hydroxybenzoic acid amide is a typical embodiment, are prepared by the reaction of an appropriately substituted benzoic acid, or derivative thereof, with an appropriate amine.

Abstract translation: 特征在于苯环中存在羟基或氨基取代基或其烷基化或酰化衍生物和通过烃链与酰胺氮原子连接的杂环基的苯甲酸酰胺是抗菌剂，特别是抗结核剂 。 其中N- [吡啶基 - （2） - 甲基] -2-羟基苯甲酸酰胺是其典型实施方案的化合物通过适当取代的苯甲酸或其衍生物与适当的胺的反应制备。