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1.发明授权Method for extracellular matrix mediated differentiation and proliferation of stem cells 失效细胞外基质介导干细胞分化和增殖的方法公开(公告)号：US08372643B2
公开(公告)日：2013-02-12
申请号：US12746512
申请日：2008-12-05
CPC分类号： C12N5/0606 , C12N5/0663 , C12N2502/13 , C12N2502/22 , C12N2502/256 , C12N2533/90
摘要： There is provided a method of culturing a stem cell on extracellular matrix extracted from support cells and in a stem cell culture medium comprising medium conditioned by the support cells.
摘要翻译： 提供了一种培养从支持细胞提取的细胞外基质上的干细胞的方法，以及包含由支持细胞调节的培养基的干细胞培养基。
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2.发明申请METHOD FOR EXTRACELLULAR MATRIX MEDIATED DIFFERENTIATION AND PROLIFERATION OF STEM CELLS 失效超细胞基质介导的分化和干细胞增殖的方法公开(公告)号：US20100285585A1
公开(公告)日：2010-11-11
申请号：US12746512
申请日：2008-12-05
IPC分类号： C12N5/0775
CPC分类号： C12N5/0606 , C12N5/0663 , C12N2502/13 , C12N2502/22 , C12N2502/256 , C12N2533/90
摘要： There is provided a method of culturing a stem cell on extracellular matrix extracted from support cells and in a stem cell culture medium comprising medium conditioned by the support cells
摘要翻译： 提供了一种培养从支持细胞提取的细胞外基质上的干细胞的方法，以及包含由支持细胞调节的培养基的干细胞培养基
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3.发明申请公开(公告)号：US20100111917A1
公开(公告)日：2010-05-06
申请号：US12293801
申请日：2006-10-17
CPC分类号： A61L27/34
摘要： A multilayer polyelectrolyte support material is provided that includes a polyelectrolyte layer and a polyelectrolyte-polyethylene glycol layer adjacent to the polyelectrolyte layer. The support material also includes a ligand conjugated to the polyelectrolyte-polyethylene glycol layer, allowing for attachment of a protein or a cell to the support material with controlled orientation.
摘要翻译： 提供了多层聚电解质载体材料，其包括聚电解质层和邻近聚电解质层的聚电解质 - 聚乙二醇层。 支持材料还包括与聚电解质 - 聚乙二醇层缀合的配体，允许蛋白质或细胞与受控取向的载体材料连接。
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4.发明授权Method for differentiating embryonic stem cells into cells expressing AQP-1 有权将胚胎干细胞分化成表达AQP-1的细胞的方法公开(公告)号：US08481316B2
公开(公告)日：2013-07-09
申请号：US12669457
申请日：2008-07-21
申请人： Karl M. Schumacher , Jackie Y. Ying , Annegret Schumacher , Karthikeyan Narayanan , Gunter Maubach
发明人： Karl M. Schumacher , Jackie Y. Ying , Annegret Schumacher , Karthikeyan Narayanan , Gunter Maubach
CPC分类号： C12N5/0686 , A61F2/06 , C12N2501/11 , C12N2501/155 , C12N2506/02
摘要： The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis.
摘要翻译： 本发明涉及将人胚胎干（ES）细胞分化成表达AQP-1的细胞，特别是肾上皮细胞的方法。 所公开的方法包括在细胞外基质分子的存在下在肾特异性培养基中培养人ES细胞。 根据所述方法产生的细胞可用于治疗肾脏相关疾病如肾衰竭，肾病，光明病和肾小球炎。
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5.发明申请METHOD FOR DIFFERENTIATING EMBRYONIC STEM CELLS INTO CELLS EXPRESSING AQP-1 有权将胚胎干细胞分化成表达AQP-1的细胞的方法公开(公告)号：US20110070280A1
公开(公告)日：2011-03-24
申请号：US12669457
申请日：2008-07-21
申请人： Karl M. Schumacher , Jackie Y. Ying , Annegret Schumacher , Karthikeyan Narayanan , Gunter Maubach
发明人： Karl M. Schumacher , Jackie Y. Ying , Annegret Schumacher , Karthikeyan Narayanan , Gunter Maubach
IPC分类号： A61F2/00 , C12N5/0735 , A61K35/12 , A61P13/12
CPC分类号： C12N5/0686 , A61F2/06 , C12N2501/11 , C12N2501/155 , C12N2506/02
摘要： The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis.
摘要翻译： 本发明涉及将人胚胎干（ES）细胞分化成表达AQP-1的细胞，特别是肾上皮细胞的方法。 所公开的方法包括在细胞外基质分子的存在下在肾特异性培养基中培养人ES细胞。 根据所述方法产生的细胞可用于治疗肾脏相关疾病如肾衰竭，肾病，光明病和肾小球炎。
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