公开(公告)号：US07738946B2

公开(公告)日：2010-06-15

申请号：US11906706

申请日：2007-10-03

Applicant: Marlin O. Thurston ,  Helen Thurston, legal representative ,  Karl W. Olson

Inventor： Marlin O. Thurston ,  Karl W. Olson

IPC: A61B6/00 ,  A61B8/00

CPC classification number: A61B5/0059 ,  A61B5/415 ,  A61B5/418

Abstract: System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing (e.g., nanocrystal) tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.

Abstract translation: 系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光（例如，纳米晶体）示踪剂结合使用。 探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。 描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

公开(公告)号：US5857463A

公开(公告)日：1999-01-12

申请号：US543032

申请日：1995-10-13

Applicant: Marlin O. Thurston ,  Karl W. Olson

Inventor： Marlin O. Thurston ,  Karl W. Olson

IPC: G01T1/161 ,  G01T1/24 ,  A61B5/00

CPC classification number: G01T1/161 ,  A61B6/4258 ,  Y10S977/873

Abstract: System and apparatus particularly suited for tracking a radiopharmaceutical present within a lymph duct and locating a sentinel node within which the radiopharmaceutical has concentrated. A smaller, straight, hand-held probe is employed carrying two hand actuable switches. For tracking procedures, the probe is moved in an undulatory manner wherein the location of the radiopharmaceutical containing duct is determined by observing a graphics readout developed preferably employing a circularly accessed data memory. When the region of the sentinel node is approached, a switch on the probe device is actuated by the surgeon to carry out a sequence of squelching operations until a small node locating region is defined. At that point in the procedure, the straight small probe will be pointed at and in adjacency with the radiopharmaceutical containing sentinel node. The probe-mounted switches are configured to apply preset current levels upon the probe pre-amplifier power supply. These levels are detected, identified by a discriminator and emulating signals are generated. A sterilizable remote switch provides a squelch threaded level trim function.

Abstract translation: 特别适用于跟踪存在于淋巴管内的放射性药物并定位放射性药物集中在其中的前哨淋巴结的系统和装置。 采用较小直的手持式探头承载双手可致动开关。 对于跟踪程序，探针以波动方式移动，其中通过观察优选采用循环访问的数据存储器开发的图形读出来确定放射性药物容纳管道的位置。 当前哨淋巴结的区域接近时，外科医生启动探针装置上的一个开关，以执行一系列压制操作，直到定义小节点定位区域。 在该过程的那一点上，直接的小探针将被指向并且与包含前哨淋巴结的放射性药物相邻。 探头安装的开关配置为在探头前置放大器电源上施加预设电流电平。 通过鉴别器检测这些电平，并产生仿真信号。 可灭菌的遥控开关提供静噪线程调整功能。

公开(公告)号：US5740080A

公开(公告)日：1998-04-14

申请号：US680831

申请日：1996-07-16

Applicant: William B. Shook ,  Dennis R. Pugh ,  Karl W. Olson

Inventor： William B. Shook ,  Dennis R. Pugh ,  Karl W. Olson

IPC: G01K1/02 ,  G01K7/02 ,  G01K13/00 ,  G01K7/00

CPC classification number: G01K7/021 ,  G01K1/024 ,  G01K13/00

Abstract: An industrial mobile process monitoring system is described which provides a means by which a measurable atmospheric condition, such as temperature, can be measured in real time at a plurality of different locations in a structure such as a kiln, and the information transmitted to a base station computer via magnetic energy linking primary and secondary windings of an air-core transformer.

Abstract translation: 描述了一种工业移动过程监控系统，其提供了一种方法，通过该工具可以在诸如窑炉的结构中的多个不同位置实时地测量诸如温度的可测量的大气条件，并且将信息传输到基座 空气变压器的主要和次级绕组的磁能连接。

公开(公告)号：US20080281208A1

公开(公告)日：2008-11-13

申请号：US11906706

申请日：2007-10-03

Applicant: Marlin O. Thurston ,  Helen Thurston ,  Karl W. Olson

Inventor： Marlin O. Thurston ,  Helen Thurston ,  Karl W. Olson

IPC: A61B5/00

CPC classification number: A61B5/0059 ,  A61B5/415 ,  A61B5/418

Abstract: System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing (e.g., nanocrystal) tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.

Abstract translation: 系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光（例如，纳米晶体）示踪剂结合使用。 探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。 描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

公开(公告)号：US06222193B1

公开(公告)日：2001-04-24

申请号：US09167704

申请日：1998-10-06

Applicant: Marlin O. Thurston ,  Karl W. Olson

Inventor： Marlin O. Thurston ,  Karl W. Olson

IPC: A61B600

CPC classification number: G01T1/161 ,  A61B6/4258

Abstract: A hand-held surgical probe is provided with a crystal detector mount architecture wherein a rigid mounting of key components is achieved. In one embodiment, the crystal detector mount is supported and suspended by a vibration damping suspension externally located with respect to the crystal detector mount. The crystal detector mount architecture and vibration damping suspension act to reduce a variety of noise phenomena.

Abstract translation: 手持式手术探针具有晶体检测器安装架构，其中实现了关键部件的刚性安装。 在一个实施例中，晶体检测器支架由相对于晶体检测器支架外部的振动阻尼悬架支撑和悬挂。 晶体检测器安装架构和减震悬架可减少各种噪声现象。

公开(公告)号：US5732704A

公开(公告)日：1998-03-31

申请号：US542955

申请日：1995-10-13

Applicant: Marlin O. Thurston ,  Karl W. Olson ,  Richard C. Orahood ,  Michael D. Magill

Inventor： Marlin O. Thurston ,  Karl W. Olson ,  Richard C. Orahood ,  Michael D. Magill

IPC: G01T1/161 ,  A61B6/00

CPC classification number: A61B6/4258 ,  G01T1/161 ,  A61B6/4423 ,  Y10S977/906

Abstract: The method for identifying a sentinel lymph node located within a grouping of regional nodes at a lymph draininage basin associated with neoplastic tissue wherein a radiopharmaceutical is injected at the situs of the neoplastic tissue. This radiopharmaceutical migrates along a lymph duct toward the drainage basin containing the sentinel node. A hand-held probe with a forwardly disposed radiation detector crystal is maneuvered along the duct while the clinician observes a graphical readout of count rate amplitudes to determine when the probe is aligned with the duct. The region containing the sentinel node is identified when the count rate at the probe substantially increases. Following incision, the probe is maneuvered utilizing a sound output in connection with actuation of the probe to establish increasing count rate thresholds followed by incremental movements until the threshold is not reached and no sound cue is given the surgeon. At this point of the maneuvering of the probe its detector will be in adjacency with the sentinel node which then may be removed.

Abstract translation: 用于鉴定位于与肿瘤组织相关的淋巴流域盆地的一组区域节点内的前哨淋巴结的方法，其中在肿瘤组织的位置注射放射性药物。 这种放射性药物沿着淋巴管向包含前哨淋巴结的排水盆移动。 具有向前布置的放射线检测器晶体的手持式探针沿管道操纵，而临床医生观察计数速率幅度的图形读出以确定探针何时与导管对准。 当探头的计数率显着增加时，识别包含前哨节点的区域。 在切割之后，使用与探针的致动相关联的声音输出来操纵探针，以建立增加的计数率阈值，随后进行增量移动，直到阈值未达到，并且外科医生没有给出声音提示。 在探测器的这一点上，探测器将与前哨节点邻接，然后可以将其移除。

公开(公告)号：US5572445A

公开(公告)日：1996-11-05

申请号：US288567

申请日：1994-08-10

Applicant: William B. Shook ,  Dennis R. Pugh ,  Karl W. Olson

Inventor： William B. Shook ,  Dennis R. Pugh ,  Karl W. Olson

IPC: G01K1/02 ,  G01K7/02 ,  G01K13/00 ,  G01K7/00

CPC classification number: G01K7/021 ,  G01K1/024 ,  G01K13/00

Abstract: An industrial mobile process monitoring system is described which provides a means by which a measurable atmospheric condition, such as temperature, can be measured in real time at a plurality of different locations in a structure such as a kiln, and the information transmitted to a base station computer via magnetic energy linking primary and secondary windings of an air-core transformer.

Abstract translation: 描述了一种工业移动过程监控系统，其提供了一种方法，通过该工具可以在诸如窑炉的结构中的多个不同位置实时地测量诸如温度的可测量的大气条件，并且将信息传输到基座 空气变压器的主要和次级绕组的磁能连接。

公开(公告)号：US5475219A

公开(公告)日：1995-12-12

申请号：US329505

申请日：1994-10-26

Applicant: Karl W. Olson

Inventor： Karl W. Olson

IPC: G01T1/161 ,  G01T1/24

CPC classification number: G01T1/161 ,  A61B6/4258

Abstract: A system for detecting photon emissions wherein a detector serves to derive electrical parameter signals having amplitudes corresponding with the detected energy of the photon emissions and other signal generating events. Two comparator networks are employed within an energy window defining function to develop an output, L, when an event based signal amplitude is equal to or above a threshold value, and to develop an output, H, when such signal amplitude additionally extends above an upper limit. Improved reliability and accuracy is achieved with a discriminator circuit which responds to these outputs L and H to derive an event output upon the occurrence of an output L in the absence of an output H. This discriminator circuit is an asynchronous, sequential, fundamental mode discriminator circuit with three stable states.

Abstract translation: 一种用于检测光子发射的系统，其中检测器用于导出具有与检测到的光子发射能量和其它信号产生事件相对应的振幅的电参数信号。 当基于事件的信号幅度等于或高于阈值时，在能量窗口定义函数中使用两个比较器网络来产生输出L，并且当这种信号幅度另外延伸到上面的上方时产生输出H 限制。 通过鉴别器电路可以实现提高的可靠性和准确度，该鉴频器电路响应于这些输出L和H以在没有输出H的情况下在出现输出L时导出事件输出。该鉴频电路是异步的，顺序的基本模式鉴别器 电路具有三个稳定状态。

公开(公告)号：US4241519A

公开(公告)日：1980-12-30

申请号：US6333

申请日：1979-01-25

Applicant: Richard D. Gilson ,  Marlin O. Thurston ,  Karl W. Olson ,  Ronald W. Ventola

Inventor： Richard D. Gilson ,  Marlin O. Thurston ,  Karl W. Olson ,  Ronald W. Ventola

IPC: G09B9/30 ,  G09B9/08 ,  H04N7/18

CPC classification number: G09B9/302

Abstract: A flight simulator arrangement wherein a conventional, movable base flight trainer is combined with a visual cue display surface spaced a predetermined distance from an eye position within the trainer. Thus, three degrees of motive freedom (roll, pitch and crab) are provided for a visual proprioceptive, and vestibular cue system by the trainer while the remaining geometric visual cue image alterations are developed by a video system. A geometric approach to computing runway image eliminates a need to electronically compute trigonometric functions, while utilization of a line generator and designated vanishing point at the video system raster permits facile development of the images of the longitudinal edges of the runway.

Abstract translation: 一种飞行模拟器装置，其中常规的可移动基本飞行训练器与与训练器内的眼睛位置间隔开预定距离的视觉提示显示表面组合。 因此，为视觉本体感觉提供三个动量自由度（滚动，俯仰和螃蟹），训练者提供前庭提示系统，而由视频系统开发剩余的几何视觉提示图像改变。 计算跑道图像的几何方法消除了电子计算三角函数的需要，而在视频系统光栅处利用线路发生器和指定的消失点可以容易地开发跑道纵向边缘的图像。

公开(公告)号：US5495111A

公开(公告)日：1996-02-27

申请号：US329319

申请日：1994-10-26

Applicant: Marlin O. Thurston ,  Karl W. Olson

Inventor： Marlin O. Thurston ,  Karl W. Olson

IPC: G01T1/29 ,  G01T7/00 ,  G01T1/24

CPC classification number: G01T1/2942 ,  G01T7/00

Abstract: Intended for use in a pathology laboratory, the apparatus includes a multi-segment crystal array over which is positioned a platform supported receiving region with a pattern carrying indicia emulating and in registry with the pattern of the crystal array segments. The tissue carrying a radiolabeled locator is positioned on the receiving region and the photon emission count values for each segment are compiled and displayed at a computer monitor or as a print-out in conjunction with crystal segment identification. Observation of the count values by a pathologist then shows the location over a segment of highest count value at which locator is more likely to be concentrated. Sectioning then is carried out at that location.

Abstract translation: 旨在用于病理学实验室中，该装置包括多段晶体阵列，在其上定位有平台支撑的接收区域，其具有模拟模式并与晶体阵列段的图案对齐的模式。 携带放射性标记的定位器的组织定位在接收区域上，并且每个段的光子发射计数值被编译并显示在计算机监视器处或作为结合晶片段识别的打印输出。 然后由病理学家观察计数值，然后显示定位器更有可能集中在最高计数值的一段上的位置。 然后在那个地方执行剖面。