公开(公告)号：US06875757B2

公开(公告)日：2005-04-05

申请号：US09811838

申请日：2001-03-19

申请人： Duane D. Miller ,  Gabor Tigyi ,  James T. Dalton ,  Vineet M. Sardar ,  Don B. Elrod ,  Huiping Xu ,  Daniel L. Baker ,  Dean Wang ,  Karoly Liliom ,  David J. Fischer ,  Tamas Virag ,  Nora Nusser

发明人： Duane D. Miller ,  Gabor Tigyi ,  James T. Dalton ,  Vineet M. Sardar ,  Don B. Elrod ,  Huiping Xu ,  Daniel L. Baker ,  Dean Wang ,  Karoly Liliom ,  David J. Fischer ,  Tamas Virag ,  Nora Nusser

IPC分类号： C12N15/09 ,  A61K31/27 ,  A61K31/66 ,  A61K31/685 ,  A61P17/02 ,  A61P35/00 ,  A61P43/00 ,  C07F9/09 ,  C07F9/10 ,  C07F9/11 ,  C07F9/17 ,  C07F9/22 ,  C07F9/38 ,  C07F9/40 ,  A61K31/661 ,  C07F9/06

CPC分类号： C07F9/4028 ,  A61K31/27 ,  A61K31/66 ,  C07F9/091 ,  C07F9/093 ,  C07F9/094 ,  C07F9/098 ,  C07F9/11 ,  C07F9/17 ,  C07F9/222 ,  C07F9/3808

摘要： The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.

公开(公告)号：US20050261252A1

公开(公告)日：2005-11-24

申请号：US11067884

申请日：2005-02-28

申请人： Duane Miller ,  Gabor Tigyi ,  James Dalton ,  Vineet Sardar ,  Don Elrod ,  Huiping Xu ,  Daniel Baker ,  Dean Wang ,  Karoly Liliom ,  David Fischer ,  Tamas Virag ,  Nora Nusser

发明人： Duane Miller ,  Gabor Tigyi ,  James Dalton ,  Vineet Sardar ,  Don Elrod ,  Huiping Xu ,  Daniel Baker ,  Dean Wang ,  Karoly Liliom ,  David Fischer ,  Tamas Virag ,  Nora Nusser

IPC分类号： C12N15/09 ,  A61K31/27 ,  A61K31/66 ,  A61K31/685 ,  A61P17/02 ,  A61P35/00 ,  A61P43/00 ,  C07F9/09 ,  C07F9/10 ,  C07F9/11 ,  C07F9/17 ,  C07F9/22 ,  C07F9/38 ,  C07F9/40 ,  A61K31/675 ,  A61K31/663 ,  C07F9/28

摘要： The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.

摘要翻译： 本发明涉及本文公开的式（I）化合物以及包括那些化合物的药物组合物。 还公开了使用这些化合物的方法，其具有活性作为LPA受体的激动剂或拮抗剂; 这些方法包括抑制LPA受体的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖和治疗伤口。