Methods and Systems to Determine Fetal Sex and Detect Fetal Abnormalities
    3.
    发明申请
    Methods and Systems to Determine Fetal Sex and Detect Fetal Abnormalities 审中-公开
    确定胎儿性别和检测胎儿异常的方法和系统

    公开(公告)号:US20080108071A1

    公开(公告)日:2008-05-08

    申请号:US11869064

    申请日:2007-10-09

    IPC分类号: C12Q1/68 A61B8/13

    摘要: Non-invasive methods for determining the sex of a human fetus and predicting other genetic abnormalities are disclosed. The methods include screening a maternal sample for biomarkers known to be associated with risk of genetic abnormalities; removing all or substantially all nucleated and anucleated cell populations from the maternal sample to obtain a remaining material; detecting in the remaining material, the presence of nucleic acid; and determining the sex of the fetus from the nucleic acid wherein the presence of a certain marker is indicative of a male fetus; performing an ultrasound scan which yields quantitative measurements of the fetus; and interpreting the results of the genetic abnormality screening in conjunction with the ultrasound measurements.

    摘要翻译: 公开了用于确定人胎儿性别和预测其他遗传异常的非侵入性方法。 这些方法包括筛选已知与遗传异常风险相关的生物标志物的母体样品; 从母体样品中去除所有或基本上所有的有核和无核细胞群体以获得剩余的材料; 在剩余物质中检测核酸的存在; 以及确定来自核酸的胎儿的性别,其中某一标记物的存在指示男性胎儿; 执行产生胎儿定量测量的超声扫描; 并结合超声测量解释遗传异常筛查的结果。