IgE isoforms and methods of use
    3.
    发明授权
    IgE isoforms and methods of use 失效
    IgE异构体和使用方法

    公开(公告)号:US6043345A

    公开(公告)日:2000-03-28

    申请号:US601184

    申请日:1996-02-14

    IPC分类号: A61K38/00 C07K16/00

    摘要: Methods and compositions are provided relating to novel IgE isoforms and their use in immune hypersensitivity diagnosis and treatment. The compositions include transcription and translation products of the immunoglobulin epsilon locus, specific probes for epsilon transcription products, and compounds that specifically bind epitopes of epsilon translation products. Novel products of the epsilon locus include the following transcription products and translation products thereof: CH4-M2", CH4'-CH5-M1'-M2, CH4'-CH5-M2', CH4'-CH5-M2.increment. and CH4-M2'. Such epsilon products, specific probes and binding compounds find use in methods and kits for immune hypersensitivity diagnosis and treatment.

    摘要翻译: 提供了关于新型IgE同种型及其在免疫超敏反应诊断和治疗中的应用的方法和组合物。 组合物包括免疫球蛋白ε位点的转录和翻译产物,ε转录产物的特异性探针和特异性结合ε平衡产物表位的化合物。 ε位点的新产物包括以下转录产物及其翻译产物:CH4-M2“,CH4'-CH5-M1'-M2,CH4'-CH5-M2',CH4'-CH5-M2 INCREMENT和CH4- M2'。 这种ε产品,特异性探针和结合化合物可用于免疫超敏反应诊断和治疗的方法和试剂盒。