公开(公告)号：US08859597B2

公开(公告)日：2014-10-14

申请号：US13454702

申请日：2012-04-24

Applicant: Albert Edge ,  Sang-Jun Jeon ,  Kathleen Seyb ,  Marcie Glicksman ,  Lixin Qiao ,  Gregory D. Cuny

Inventor： Albert Edge ,  Sang-Jun Jeon ,  Kathleen Seyb ,  Marcie Glicksman ,  Lixin Qiao ,  Gregory D. Cuny

IPC: A61K31/41 ,  A61K31/381 ,  A61K31/423 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/343 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/341 ,  A61K31/428

CPC classification number: A61K31/5377 ,  A61K9/0046 ,  A61K31/341 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/498 ,  A61K31/517 ,  A61K31/519 ,  A61K35/28 ,  A61K35/545

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract translation: 本发明通常提供化合物，药物组合物及其使用方法，其包括导致生物细胞中Atoh1基因（例如Hath1）表达增加的方法。 更具体地，本发明涉及可以从Atoh1表达增加中受益的疾病和/或病症的治疗，例如与听觉毛细胞丧失相关的听力损伤或不平衡障碍或与异常细胞增殖相关的病症。

公开(公告)号：US08188131B2

公开(公告)日：2012-05-29

申请号：US12368173

申请日：2009-02-09

Applicant: Albert Edge ,  Sang-Jun Jeon ,  Kathleen Seyb ,  Marcie Glicksman ,  Lixin Qiao ,  Gregory D. Cuny

Inventor： Albert Edge ,  Sang-Jun Jeon ,  Kathleen Seyb ,  Marcie Glicksman ,  Lixin Qiao ,  Gregory D. Cuny

IPC: A61K31/415

CPC classification number: A61K31/5377 ,  A61K9/0046 ,  A61K31/341 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/498 ,  A61K31/517 ,  A61K31/519 ,  A61K35/28 ,  A61K35/545

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract translation: 本发明通常提供化合物，药物组合物及其使用方法，其包括导致生物细胞中Atoh1基因（例如Hath1）表达增加的方法。 更具体地，本发明涉及可以从Atoh1表达增加中受益的疾病和/或病症的治疗，例如与听觉毛细胞丧失相关的听力损伤或不平衡障碍或与异常细胞增殖相关的病症。

公开(公告)号：US20120328580A1

公开(公告)日：2012-12-27

申请号：US13454702

申请日：2012-04-24

Applicant: Albert Edge ,  Sang-Jun Jeon ,  Kathleen Seyb ,  Marcie Glicksman ,  Lixin Qiao ,  Gregory D. Cuny

Inventor： Albert Edge ,  Sang-Jun Jeon ,  Kathleen Seyb ,  Marcie Glicksman ,  Lixin Qiao ,  Gregory D. Cuny

IPC: A61K31/4245 ,  A61K31/454 ,  A61P27/16 ,  A61P35/00 ,  C12N5/0775 ,  A61K35/12 ,  C12N5/071 ,  C12N5/0735 ,  C12N5/074 ,  A61K31/4439 ,  A61P19/02

CPC classification number: A61K31/5377 ,  A61K9/0046 ,  A61K31/341 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/498 ,  A61K31/517 ,  A61K31/519 ,  A61K35/28 ,  A61K35/545

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract translation: 本发明通常提供化合物，药物组合物及其使用方法，其包括导致生物细胞中Atoh1基因（例如Hath1）表达增加的方法。 更具体地，本发明涉及可以从Atoh1表达增加中受益的疾病和/或病症的治疗，例如与听觉毛细胞丧失相关的听力损伤或不平衡障碍或与异常细胞增殖相关的病症。

公开(公告)号：US20090232780A1

公开(公告)日：2009-09-17

申请号：US12368173

申请日：2009-02-09

Applicant: Albert Edge ,  Sang-Jun Jeon ,  Kathleen Seyb ,  Marcie Glicksman ,  Lixin Qiao ,  Gregory D. Cuny

Inventor： Albert Edge ,  Sang-Jun Jeon ,  Kathleen Seyb ,  Marcie Glicksman ,  Lixin Qiao ,  Gregory D. Cuny

IPC: A61K35/12 ,  C12N5/02 ,  A61K31/5377 ,  A61K31/53 ,  A61K31/445 ,  A61K31/41

CPC classification number: A61K31/5377 ,  A61K9/0046 ,  A61K31/341 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/498 ,  A61K31/517 ,  A61K31/519 ,  A61K35/28 ,  A61K35/545

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract translation: 本发明通常提供化合物，药物组合物及其使用方法，其包括导致生物细胞中Atoh1基因（例如Hath1）表达增加的方法。 更具体地，本发明涉及可以从Atoh1表达增加中受益的疾病和/或病症的治疗，例如与听觉毛细胞丧失相关的听力损伤或不平衡障碍或与异常细胞增殖相关的病症。