公开(公告)号：US4077968A

公开(公告)日：1978-03-07

申请号：US730965

申请日：1976-10-08

Applicant: Ryozo Maeda ,  Katsumi Hirose

Inventor： Ryozo Maeda ,  Katsumi Hirose

IPC: C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/42 ,  C07D277/56 ,  A61K31/38

CPC classification number: C07D277/34 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D277/56 ,  Y10S514/825 ,  Y10S514/87

Abstract: Thiazole derivatives represented by the general formula: ##STR1## wherein A is oxygen, sulfur, imino, or NR.sub.3, wherein R.sub.3 is C.sub.1-5 alkyl, C.sub.2-5 alkenyl, C.sub.3-5 alkynyl, C.sub.3-6 cycloalkyl-C.sub.1-3 alkyl or C.sub.7-8 aralkyl; R.sub.1 is hydrogen, C.sub.1-5 alkyl, C.sub.2-5 alkenyl, C.sub.3-5 alkynyl, C.sub.3-6 cycloalkyl-C.sub.1-3 alkyl or C.sub.7-8 aralkyl; R.sub.2 is hydroxy, C.sub.1-5 alkoxy or OM, wherein M is alkali metal, or one equivalent of alkaline earth metal, cupric or aluminum cation; n is an integer of 0 or 1; X.sub.1 and X.sub.2 are independently hydrogen or C.sub.1-5 alkyl; Y.sub.1 and Y.sub.2 are independently hydrogen, halogen, C.sub.1-5 alkyl, C.sub.1-5 alkoxy or trifluoromethyl; and the group ##STR2## is linked to one of the meta or para positions of the benzene ring A, n is not 0 when A is imino and --CH.sub.2 --COR.sub.2 does not substitute the thiazole ring when A is imino, being useful as anti-inflammatory, anti-rheumatic, analgesic or anti-lipemia agents.

Abstract translation: 由以下通式表示的噻唑衍生物：其中A是氧，硫，亚氨基或NR 3，其中R 3是C 1-5烷基，C 2-5烯基，C 3-5炔基，C 3-6环烷基-C 1-3烷基 或C7-8芳烷基; R 1是氢，C 1-5烷基，C 2-5烯基，C 3-5炔基，C 3-6环烷基-C 1-3烷基或C 7-8芳烷基; R2是羟基，C1-5烷氧基或OM，其中M是碱金属，或1当量碱土金属，铜或铝阳离子; n为0或1的整数; X 1和X 2独立地是氢或C 1-5烷基; Y1和Y2独立地是氢，卤素，C1-5烷基，C1-5烷氧基或三氟甲基; 并且组与苯环A的间位或对位相连，当A为亚氨基时，n不为0，当A为亚氨基时，-CH2-COR2不取代噻唑环，可用作抗 炎性，抗风湿，镇痛或抗血脂代谢。

公开(公告)号：US4025528A

公开(公告)日：1977-05-24

申请号：US596244

申请日：1975-07-16

Applicant: Ryozo Maeda ,  Katsumi Hirose

Inventor： Ryozo Maeda ,  Katsumi Hirose

IPC: C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/42 ,  C07D277/56 ,  C07D277/54

CPC classification number: C07D277/34 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D277/56

Abstract: Thiazole derivatives represented by the general formula: ##STR1## wherein A is oxygen, sulfur, imino, or NR.sub.3, wherein R.sub.3 is C.sub.1.sub.-5 alkyl, C.sub.2.sub.-5 alkenyl, C.sub.3.sub.-5 alkynyl, C.sub.3.sub.-6 cycloalkyl-C.sub.1.sub.-3 alkyl or C.sub.7.sub.-8 aralkyl; R.sub.1 is hydrogen, C.sub.1.sub.-5 alkyl, C.sub.2.sub.-5 alkenyl, C.sub.3.sub.-5 alkynyl, C.sub.3.sub.-6 cycloalkyl-C.sub.1.sub.-3 alkyl or C.sub.7.sub.- 8 aralkyl; R.sub.2 is hydroxy, C.sub.1.sub.-5 alkoxy or OM, wherein M is alkali metal, or one equivalent of alkaline earth metal, cupric or aluminum cation; n is an integer of 0 or 1; X.sub.1 and X.sub.2 are independently hydrogen or C.sub.1.sub.-5 alkyl; Y.sub.1 and Y.sub.2 are independently hydrogen, halogen, C.sub.1.sub.-5 alkyl, C.sub.1.sub.-5 alkoxy or trifluoromethyl; and the group ##STR2## is linked to one of the meta or para positions of the benzene ring A, n is not 0 when A is imino and --CH.sub.2 --COR.sub.2 does not substitute the thiazole ring when A is imino, being useful as anti-inflammatory, anti-rheumatic, analgesic or anti-lipemia agents.

Abstract translation: 由以下通式表示的噻唑衍生物：其中A是氧，硫，亚氨基或NR 3，其中R 3是C 1-5烷基，C 2-5烯基，C 3-5炔基，C 3-6环烷基-C 1-3烷基 或C7-8芳烷基; R1是氢，C1-5烷基，C2-5烯基，C3-5炔基，C3-6环烷基C1-3烷基或C7-8芳烷基; R2是羟基，C1-5烷氧基或OM，其中M是碱金属，或1当量碱土金属，铜或铝阳离子; n为0或1的整数; X 1和X 2独立地是氢或C 1-5烷基; Y1和Y2独立地为氢，卤素，C1-5烷基，C1-5烷氧基或三氟甲基; 并且组与苯环A的间位或对位相连，当A为亚氨基时，n不为0，当A为亚氨基时，-CH2-COR2不取代噻唑环，可用作抗 炎性，抗风湿，镇痛或抗血脂代谢。

公开(公告)号：US4018785A

公开(公告)日：1977-04-19

申请号：US637479

申请日：1975-12-03

Applicant: Ryozo Maeda ,  Katsumi Hirose

Inventor： Ryozo Maeda ,  Katsumi Hirose

IPC: F23G5/14 ,  B04C9/00 ,  C07D277/42 ,  F23G5/16 ,  F23J15/00 ,  C07D277/38

CPC classification number: C07D277/42 ,  Y10S514/916

Abstract: Thiazoline derivatives represented by the general formula: ##STR1## wherein X.sub.1 represents hydrogen or methyl; Y.sub.1 and Y.sub.2 each represents hydrogen, halogen, C.sub.1.sub.-3 alkyl, C.sub.1.sub.-3 alkoxy or trifluoromethyl; R.sub.1 represents hydrogen, methyl, or ethyl; R.sub.2 represents C.sub.1.sub.-3 alkyl or C.sub.3.sub.-5 alkenyl and Z represents hydrogen, carboxy or carboxy ester group and its esters and pharmaceutically acceptable salts, synthesized by quaternization and acid-elimination reaction being useful as anti-inflammatory, anti-rheumatic, analgesic and anti-pyretic agents.

Abstract translation: 由以下通式表示的噻唑啉衍生物：其中X1表示氢或甲基; Y1和Y2各自表示氢，卤素，C1-3烷基，C1-3烷氧基或三氟甲基; R1代表氢，甲基或乙基; R2表示C1-3烷基或C3-5烯基，Z表示氢，羧基或羧基酯基，其酯和药学上可接受的盐，通过季铵化和酸消除反应合成，可用作抗炎，抗风湿，止痛和抗炎 抗热解剂。

公开(公告)号：US3994908A

公开(公告)日：1976-11-30

申请号：US635253

申请日：1975-11-25

Applicant: Ryozo Maeda ,  Katsumi Hirose

Inventor： Ryozo Maeda ,  Katsumi Hirose

IPC: C07D213/64 ,  C07D213/70 ,  C07D213/78 ,  C07D213/81 ,  C07D213/82 ,  C07D213/84 ,  C07D213/85 ,  C07D213/89 ,  C07D217/24 ,  C07D213/55

CPC classification number: C07D213/78 ,  C07D213/64 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D213/84 ,  C07D213/85 ,  C07D213/89 ,  C07D217/24 ,  Y10S514/916

Abstract: Substituted acetic acid derivatives represented by the formula: ##SPC1##Wherein X, X', X", Y, Y' and Y" each represents a hydrogen atom, an alkyl group of 1 to 8 carbon atoms, an alkoxy group of 1 to 8 carbon atoms, a hydroxy group, an acyl group, an acylamino group, an acyloxy group, an amino group, a cyano group, a nitro group, an alkoxycarbonyl group of 2 to 9 carbon atoms, an alkoxycarbonylalkyl group of 3 to 10 carbon atoms, an alkoxycarbonylamino group of 2 to 9 carbon atoms, a trifluoromethyl group, a halogen atom, a carboxy group, or a carbamoyl group, two of X, X' and X", or two of Y, Y' and Y" are optionally combined to form an alicyclic ring of 5 to 7 carbon atoms or a benzene ring, A represents an oxygen atom or a sulfur atom, R and R.sub.1 each represents a hydrogen atom or a lower alkyl group of 1 to 4 carbon atoms and Q represents the optional presence of an oxygen atom, or their alkali metal or alkali earth metal salts, being useful as anti-inflammatory, anti-rheumatic, analgesic or anti-pyretic agents, are prepared essentially by the Arndt-Eistert reaction.

Abstract translation: 由下式表示的取代的乙酸衍生物：

公开(公告)号：US20110308679A1

公开(公告)日：2011-12-22

申请号：US13161382

申请日：2011-06-15

Applicant: Katsumi Hirose ,  Naoto Kaba

Inventor： Katsumi Hirose ,  Naoto Kaba

IPC: B60C11/117 ,  B60C11/12

CPC classification number: B60C11/0304 ,  B60C11/12 ,  B60C2011/0365 ,  B60C2011/0369 ,  B60C2011/0372 ,  Y10S152/03

Abstract: A pneumatic tire, wherein the central narrow groove includes an arc, the inner diameter side of the arc is facing towards the tire ground contact edge side, one end is open to another adjacent central narrow groove and the other end is open to the circumferential main groove on the inner side area side. A first central sipe is disposed between adjacent central narrow grooves, and connects the central narrow groove and the circumferential main groove on the inner side area side. One end of the notch portion is open to the circumferential main groove on the outer side area side, and the other end terminates within the central land portion. A second central sipe is disposed between adjacent notch portions. One end of the second central sipe is connected to the circumferential main groove on the outer side area side and another end terminates within the central land portion.

Abstract translation: 一种充气轮胎，其中，所述中央窄槽包括弧形，所述弧的内径侧朝向所述轮胎接地边缘侧，一端与另一相邻的中央窄槽相通，所述另一端与所述周向主体 凹槽在内侧区域侧。 第一中心刀槽花纹布置在相邻的中央窄槽之间，并且将中央窄槽与周边主槽连接在内侧区域侧。 切口部的一端与外侧区域侧的周向主槽相通，另一端终止于中央接地部。 第二中心刀槽花纹布置在相邻的切口部分之间。 第二中央刀槽花纹的一端在外侧区域侧与周向主槽连接，另一端终止于中央陆部。

公开(公告)号：US07666472B2

公开(公告)日：2010-02-23

申请号：US10547334

申请日：2004-04-13

Applicant: Katsumi Hirose

Inventor： Katsumi Hirose

IPC: C05D7/22

CPC classification number: B29D30/0685 ,  B05D1/02 ,  B29C73/163 ,  B29D2030/0697 ,  B29L2030/00 ,  Y10T152/10684

Abstract: Disclosed is a sealing material formed of a powdered material into which a rubber base sealing material with a viscosity of 20 to 200 Pa·s/100° C. is pulverized at a temperature lower than, or equal to, a brittle temperature of the rubber base sealing material, and a method of applying the sealing material, which includes applying the powdered material to a surface to be coated with the powdered material, by a spray coating process.

Abstract translation: 公开了一种由粉末材料形成的密封材料，其中粘度为20-200Pa·s / 100℃的橡胶基础密封材料在低于或等于橡胶的脆性温度的温度下被粉碎 基础密封材料，以及施加密封材料的方法，其包括通过喷涂工艺将粉末材料施加到待涂覆粉末材料的表面上。

公开(公告)号：US4301159A

公开(公告)日：1981-11-17

申请号：US161492

申请日：1980-06-20

Applicant: Masaru Ogata ,  Hiroshi Matsumoto ,  Katsumi Hirose ,  Masami Eigyo

Inventor： Masaru Ogata ,  Hiroshi Matsumoto ,  Katsumi Hirose ,  Masami Eigyo

IPC: C07C233/12 ,  C07C311/02 ,  C07C143/74 ,  A61K31/25

CPC classification number: C07C233/12 ,  C07C311/02

Abstract: A compound of the formula: ##STR1## wherein R is alkyl;R.sup.1 is hydrogen, halogen, alkyl or alkoxy;R.sup.2 is amino, alkanoyl, ##STR2## R.sup.3 is alkyl or dialkylamino; andR.sup.4 is hydrogen or alkylwith the proviso that when R.sup.2 is amino or alkanoyl, R.sup.1 is alkyland or a pharmaceutically acceptable acid addition salt thereof, being useful as gastric disorder remedies or antiemetics are provided via several routes.

Abstract translation: 下式的化合物：其中R是烷基; R1是氢，卤素，烷基或烷氧基; R2是氨基，烷酰基，R3是烷基或二烷基氨基; R4为氢或烷基，条件是当R 2为氨基或烷酰基时，R 1为烷基和/或其药学上可接受的酸加成盐，可作为胃病症治疗剂或止吐剂用于多种途径。

公开(公告)号：US09004125B2

公开(公告)日：2015-04-14

申请号：US13161382

申请日：2011-06-15

Applicant: Katsumi Hirose ,  Naoto Kaba

Inventor： Katsumi Hirose ,  Naoto Kaba

IPC: B60C11/12 ,  B60C11/03

CPC classification number: B60C11/0304 ,  B60C11/12 ,  B60C2011/0365 ,  B60C2011/0369 ,  B60C2011/0372 ,  Y10S152/03

Abstract: A pneumatic tire, wherein the central narrow groove includes an arc, the inner diameter side of the arc is facing towards the tire ground contact edge side, one end is open to another adjacent central narrow groove and the other end is open to the circumferential main groove on the inner side area side. A first central sipe is disposed between adjacent central narrow grooves, and connects the central narrow groove and the circumferential main groove on the inner side area side. One end of the notch portion is open to the circumferential main groove on the outer side area side, and the other end terminates within the central land portion. A second central sipe is disposed between adjacent notch portions. One end of the second central sipe is connected to the circumferential main groove on the outer side area side and another end terminates within the central land portion.

Abstract translation: 一种充气轮胎，其中，所述中央窄槽包括弧形，所述弧的内径侧朝向所述轮胎接地边缘侧，一端与另一相邻的中央窄槽相通，所述另一端与所述周向主体 凹槽在内侧区域侧。 第一中心刀槽花纹布置在相邻的中央窄槽之间，并且将中央窄槽与周边主槽连接在内侧区域侧。 切口部的一端与外侧区域侧的周向主槽相通，另一端终止于中央接地部。 第二中心刀槽花纹布置在相邻的切口部分之间。 第二中央刀槽花纹的一端在外侧区域侧与周向主槽连接，另一端终止于中央陆部。

公开(公告)号：US20060148927A1

公开(公告)日：2006-07-06

申请号：US10547334

申请日：2004-04-13

Applicant: Katsumi Hirose

Inventor： Katsumi Hirose

IPC: B29C73/00 ,  B05D1/12

CPC classification number: B29D30/0685 ,  B05D1/02 ,  B29C73/163 ,  B29D2030/0697 ,  B29L2030/00 ,  Y10T152/10684

Abstract: Disclosed are a sealing material comprises a powdered material into which a rubber base sealing material with a viscosity of 20 to 200 Pa·s/100° C. is pulverized at a temperature lower than, or equal to, a brittle temperature of the rubber base sealing material, and a method of applying the sealing material, which comprising applying the powdered material to a surface, intended to be coated with the powered material, by a spay coating process.

Abstract translation: 公开了一种密封材料，其包括粉末材料，其中粘度为20-200Pa.s / 100℃的橡胶基础密封材料在低于或等于橡胶基体的脆性温度的温度下被粉碎 密封材料和施加密封材料的方法，其包括通过喷涂方法将粉末材料施加到旨在用动力材料涂覆的表面上。

公开(公告)号：USD519443S1

公开(公告)日：2006-04-25

申请号：US29211842

申请日：2004-08-24

Applicant: Hirotada Saito ,  Katsumi Hirose

Designer： Hirotada Saito ,  Katsumi Hirose