公开(公告)号：US06656229B1

公开(公告)日：2003-12-02

申请号：US09648209

申请日：2000-08-25

申请人： Kazumi Taguchi ,  Takao Tokano ,  Yoshio Yamaoka ,  Kazumaro Furuse

发明人： Kazumi Taguchi ,  Takao Tokano ,  Yoshio Yamaoka ,  Kazumaro Furuse

IPC分类号： A61K713

CPC分类号： A61K8/66 ,  A61K8/97 ,  A61Q5/10

摘要： A hair dye and hair-dyeing methods using the hair dye are provided. The hair dye comprises, as essential ingredients, (i) a formulation primarily composed of a dye component including indican derived from indigo plants and (ii) a formulation primarily composed of a &bgr;-glucosidase enzyme component. Hair is first mordanted with a dye mordant such as aluminum, iron and the like, and then secondly the prepared hair dye is uniformly applied to the hair either directly or as a mixture of the dye and a proper amount of water. Upon completion of the hair-dyeing, hair is rinsed with water and is finished by drying.

摘要翻译： 提供使用染发剂的染发剂和染发方法。 染发剂作为必需成分包含（i）主要由染料组分组成的制剂，其包含衍生自靛蓝植物的标记物和（ii）主要由β-葡糖苷酶组分组成的制剂。 头发首先与染料媒染剂如铝，铁等混合，然后将制备的染发剂直接或作为染料与适量的水的混合物均匀地施加到头发上。 染发完成后，用水冲洗头发，并通过干燥完成。

公开(公告)号：US20090162283A1

公开(公告)日：2009-06-25

申请号：US12095320

申请日：2006-11-30

申请人： Kazunori Bando ,  Kazumi Taguchi

发明人： Kazunori Bando ,  Kazumi Taguchi

IPC分类号： A61K51/04 ,  C07D413/14 ,  A61K31/4439 ,  G01N33/566 ,  A61P25/28 ,  A61K101/02 ,  C07D417/14 ,  C07D413/02 ,  C07D417/02 ,  A61K31/506 ,  A61K31/423 ,  A61K31/4245

CPC分类号： C07D471/04 ,  A61K31/423 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0459 ,  C07D235/18 ,  C07D263/57 ,  C07D277/66 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  G01N2333/4709 ,  G01N2500/04

摘要： To provide a diagnostic drug which binds specifically to an amyloid aggregate and/or an amyloid deposit, to thereby realize imaging and quantification of a disease caused by amyloid aggregation and/or deposition.The invention provides a compound represented by formula (1): (wherein X1 represents an optionally substituted bicyclic heterocyclic group; X2 represents a hydrogen atom, a halogen atom, or a chelate-forming group; ring A represents a benzene ring or a pyridine ring; and ring B represents an optionally substituted 5-membered aromatic heterocyclic group which is bonded to the benzene ring or the pyridine ring via a carbon atom of ring B), a salt thereof, a solvate of any of these, or a transition metal coordination compound of any of these, and a diagnostic, preventive, or therapeutic drug containing the same.

摘要翻译： 提供与淀粉样蛋白聚集体和/或淀粉样沉积物特异性结合的诊断药物，从而实现由淀粉样蛋白聚集和/或沉积引起的疾病的成像和定量。 本发明提供由式（1）表示的化合物：其中X1表示任选取代的双环杂环基; X2表示氢原子，卤素原子或螯合形成基团;环A表示苯环或吡啶环 环B表示任意取代的5元芳族杂环基，其通过环B）的碳原子，其盐，任何这些的溶剂合物或过渡金属配位键与苯环或吡啶环键合 任何这些的化合物，以及含有其的诊断，预防或治疗药物。

公开(公告)号：US06849096B2

公开(公告)日：2005-02-01

申请号：US10668656

申请日：2003-09-23

申请人： Kazumi Taguchi ,  Takao Tokano ,  Yoshio Yamaoka ,  Kazumaro Furuse

发明人： Kazumi Taguchi ,  Takao Tokano ,  Yoshio Yamaoka ,  Kazumaro Furuse

IPC分类号： A61K8/00 ,  A61K8/26 ,  A61K8/33 ,  A61K8/36 ,  A61K8/368 ,  A61K8/49 ,  A61K8/64 ,  A61K8/66 ,  A61K8/73 ,  A61K8/92 ,  A61K8/96 ,  A61K8/97 ,  A61Q5/10 ,  C09B61/00 ,  C09B67/42 ,  D06P1/34 ,  A61K7/13

CPC分类号： A61K8/66 ,  A61K8/97 ,  A61Q5/10

摘要： A hair dye and hair-dyeing methods using the hair dye are provided. The hair dye comprises, as essential ingredients, (i) a formulation primarily composed of a dye component-including indican derived from indigo plants and (ii) a formulation primarily composed of a β-glucosidase enzyme component. Hair is first mordanted with a dye mordant such as aluminum, iron and the like, and then secondly the prepared hair dye is uniformly applied to the hair either directly or as a mixture of the dye and a proper amount of water. Upon completion of the hair-dyeing, hair is rinsed with water and is finished by drying.

摘要翻译： 提供使用染发剂的染发剂和染发方法。 染发剂包含作为必需成分的（i）主要由含有靛蓝植物的染料成分的指示剂组成的制剂和（ii）主要由β-葡糖苷酶组分组成的制剂。 头发首先与染料媒染剂如铝，铁等混合，然后将制备的染发剂直接或作为染料与适量的水的混合物均匀地施加到头发上。 染发完成后，用水冲洗头发，并通过干燥完成。

公开(公告)号：US08022075B2

公开(公告)日：2011-09-20

申请号：US12095320

申请日：2006-11-30

申请人： Kazunori Bando ,  Kazumi Taguchi

发明人： Kazunori Bando ,  Kazumi Taguchi

IPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/5025 ,  C07D471/04 ,  C07D487/04 ,  C07D235/18 ,  C07D263/57 ,  C07D277/66

CPC分类号： C07D471/04 ,  A61K31/423 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0459 ,  C07D235/18 ,  C07D263/57 ,  C07D277/66 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  G01N2333/4709 ,  G01N2500/04

摘要： To provide a diagnostic drug which binds specifically to an amyloid aggregate and/or an amyloid deposit, to thereby realize imaging and quantification of a disease caused by amyloid aggregation and/or deposition.The invention provides a compound represented by formula (1): (wherein X1 represents an optionally substituted bicyclic heterocyclic group; X2 represents a hydrogen atom, a halogen atom, or a chelate-forming group; ring A represents a benzene ring or a pyridine ring; and ring B represents an optionally substituted 5-membered aromatic heterocyclic group which is bonded to the benzene ring or the pyridine ring via a carbon atom of ring B), a salt thereof, a solvate of any of these, or a transition metal coordination compound of any of these, and a diagnostic, preventive, or therapeutic drug containing the same.

摘要翻译： 提供与淀粉样蛋白聚集体和/或淀粉样沉积物特异性结合的诊断药物，从而实现由淀粉样蛋白聚集和/或沉积引起的疾病的成像和定量。 本发明提供由式（1）表示的化合物：其中X1表示任选取代的双环杂环基; X2表示氢原子，卤素原子或螯合形成基团;环A表示苯环或吡啶环 环B表示任意取代的5元芳族杂环基，其通过环B）的碳原子，其盐，任何这些的溶剂合物或过渡金属配位键与苯环或吡啶环键合 任何这些的化合物，以及含有其的诊断，预防或治疗药物。