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公开(公告)号：US20100240650A1
公开(公告)日：2010-09-23
申请号：US12787034
申请日：2010-05-25
申请人： Han-Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
发明人： Han-Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
IPC分类号： A61K31/5377 , C07D403/04 , A61K31/404 , A61P3/10 , A61P9/00 , A61P29/00 , A61P37/00 , A61P17/00 , A61P27/02 , A61P25/00 , C07D401/14 , A61K31/4439 , C07D403/14 , A61K31/496 , C07D413/14 , A61K31/506 , A61K31/416
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
摘要翻译： 本发明涉及用作激酶或双重激酶抑制剂的新型取代的吡咯啉化合物，用于制备这些化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。
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公开(公告)号：US07608634B2
公开(公告)日：2009-10-27
申请号：US11800912
申请日：2007-05-08
申请人： Han-Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
发明人： Han-Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
IPC分类号： A61K31/415 , A61K31/40
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
摘要翻译： 本发明涉及用作激酶或双重激酶抑制剂的新型取代的吡咯啉化合物，用于制备这些化合物的方法以及用于治疗或改善激酶或双重激酶介导的病症的方法。
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公开(公告)号：US07232906B2
公开(公告)日：2007-06-19
申请号：US10454561
申请日：2003-06-04
申请人： Han Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
发明人： Han Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
IPC分类号： C07D239/24 , C07D209/02
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
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公开(公告)号：US07329657B2
公开(公告)日：2008-02-12
申请号：US10909537
申请日：2004-08-02
申请人： Han-Cheng Zhang , Bruce Maryanoff , Bruce Conway , Kimberly White , Hong Ye , Leonard Robert Hecker , David F. McComsey
发明人： Han-Cheng Zhang , Bruce Maryanoff , Bruce Conway , Kimberly White , Hong Ye , Leonard Robert Hecker , David F. McComsey
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/4709 , A61K31/4439 , C07D403/14 , C07D217/22 , C07D231/56
CPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
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公开(公告)号：US07304060B2
公开(公告)日：2007-12-04
申请号：US10885373
申请日：2004-07-06
申请人： Han-Cheng Zhang , Bruce Maryanoff , Bruce Conway , Kimberly White , Hong Ye , Leonard Robert Hecker , David F. McComsey
发明人： Han-Cheng Zhang , Bruce Maryanoff , Bruce Conway , Kimberly White , Hong Ye , Leonard Robert Hecker , David F. McComsey
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/4709 , A61K31/4439 , C07D403/14 , C07D217/22 , C07D231/56
CPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
摘要翻译： 本发明涉及式（I）的新的吲唑基取代的吡咯啉化合物：
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公开(公告)号：US06849643B2
公开(公告)日：2005-02-01
申请号：US10013181
申请日：2001-12-06
申请人： Han-Cheng Zhang , Bruce Maryanoff , Bruce Conway , Kimberly White , Hong Ye , Leonard Robert Hecker , David F. McComsey
发明人： Han-Cheng Zhang , Bruce Maryanoff , Bruce Conway , Kimberly White , Hong Ye , Leonard Robert Hecker , David F. McComsey
IPC分类号： A61K31/416 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P17/00 , A61P17/06 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/28 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , A61K31/4709 , A61K31/4725
CPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
摘要翻译： 本发明涉及式（I）的新的吲唑基取代的吡咯啉化合物：可用作激酶或双重激酶抑制剂，用于制备这些化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。
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公开(公告)号：US20070213387A1
公开(公告)日：2007-09-13
申请号：US11800912
申请日：2007-05-08
申请人： Han-Cheng Zhang , Bruce Maryanoff , David McComsey , Kimberly White , Hong Ye , Leonard Hecker , Bruce Conway , Keith Demarest
发明人： Han-Cheng Zhang , Bruce Maryanoff , David McComsey , Kimberly White , Hong Ye , Leonard Hecker , Bruce Conway , Keith Demarest
IPC分类号： A61K31/415 , A61K31/40
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
摘要翻译： 本发明涉及用作激酶或双重激酶抑制剂的新型取代的吡咯啉化合物，用于制备这些化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。
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公开(公告)号：US20070213386A1
公开(公告)日：2007-09-13
申请号：US11800878
申请日：2007-05-08
申请人： Han-Cheng Zhang , Bruce Maryanoff , David McComsey , Kimberly White , Hong Ye , Leonard Hecker , Bruce Conway , Keith Demarest
发明人： Han-Cheng Zhang , Bruce Maryanoff , David McComsey , Kimberly White , Hong Ye , Leonard Hecker , Bruce Conway , Keith Demarest
IPC分类号： A61K31/40 , A61K31/415 , C07D209/02 , C07D221/00 , C07D231/56 , C07D239/02 , C07D401/02
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
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公开(公告)号：US06828327B2
公开(公告)日：2004-12-07
申请号：US10008982
申请日：2001-12-06
申请人： Gee-Hong Kuo , Han-Cheng Zhang , Catherine Prouty , Alan DeAngelis , Peter Connolly , William V. Murray , Lan Shen , Bruce Conway , Keith Demarest , Chandra R. Shah , Bruce E. Maryanoff , Kimberly B. White
发明人： Gee-Hong Kuo , Han-Cheng Zhang , Catherine Prouty , Alan DeAngelis , Peter Connolly , William V. Murray , Lan Shen , Bruce Conway , Keith Demarest , Chandra R. Shah , Bruce E. Maryanoff , Kimberly B. White
IPC分类号： A61K3144
CPC分类号： C07D471/22 , C07D487/22 , C07D498/22 , C07D515/22
摘要： This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
摘要翻译： 本发明涉及可用作激酶或双重激酶抑制剂的大量杂环化合物，用于制备此类化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。
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公开(公告)号：US20060205763A1
公开(公告)日：2006-09-14
申请号：US11436000
申请日：2006-05-17
申请人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce Conway , David McComsey
发明人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce Conway , David McComsey
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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