公开(公告)号：US20050163745A1

公开(公告)日：2005-07-28

申请号：US10620686

申请日：2003-07-17

申请人： Kenneth Sokoll ,  Pele Chong ,  Michel Klein

发明人： Kenneth Sokoll ,  Pele Chong ,  Michel Klein

IPC分类号： A61K9/48 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K39/39 ,  A61K47/34 ,  C08G63/685 ,  C08G63/688 ,  C08G63/78 ,  C08G75/26 ,  C08J3/14 ,  C08J5/18 ,  C08K5/00 ,  C08L101/16 ,  A61K31/785

CPC分类号： A61K9/1647 ,  A61K9/167 ,  A61K2039/55555 ,  C08G63/6852 ,  Y10S514/952 ,  Y10S530/815 ,  Y10S530/816 ,  Y10T428/2982

摘要： Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligands are described. The copolymers are polyesters composed of α-hydroxy acid subunits such as D,L-lactide and pseudo-α-amino acid subunits which may be derived from serine or terpolymers of D,L-lactide and glycolide and pseudo-α-amino acid subunits which may be derived from serine. Stable vaccine preparations useful as delayed release formulations containing antigen or antigens and adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody and protective responses.

摘要翻译： 描述了设计用作颗粒载体的共聚物，其含有用于与靶配体偶联的可官能化氨基酸亚单位。 共聚物是由α-羟基酸亚基如D，L-丙交酯和拟α-氨基酸亚基组成的聚酯，其可衍生自D，L-丙交酯和乙交酯的丝氨酸或三元共聚物和假α-氨基酸亚基 其可以来自丝氨酸。 描述了可用作包含包封在聚合物微粒内或与聚合物微粒物理混合的抗原或抗原和佐剂的延迟释放制剂的稳定的疫苗制剂。 颗粒载体可用于通过粘膜或肠胃外途径将药剂递送至受试者的免疫系统，以产生免疫应答，包括抗体和保护性反应。