公开(公告)号：US07811605B2

公开(公告)日：2010-10-12

申请号：US10960461

申请日：2004-10-06

申请人： Daniel G. Moro ,  John V. St. John ,  Kevin F. Shannon ,  Bill C. Ponder

发明人： Daniel G. Moro ,  John V. St. John ,  Kevin F. Shannon ,  Bill C. Ponder

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  G02C7/04

CPC分类号： A61L27/52 ,  A61K9/0024 ,  A61K9/1635 ,  A61K9/5138 ,  A61K9/5192 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/442 ,  A61L2300/602 ,  C08L33/14 ,  C08L71/00 ,  C08L2312/00 ,  C08L2666/16

摘要： The present invention relates to a method of forming shape-retentive aggregates of gel particles in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a suspension of gel particles in a polar liquid at a selected concentration, wherein the gel particles have an absolute zeta potential, into a medium in which the absolute zeta potential of the gel particles is decreased, resulting in the gel particles coalescing into the claimed shape-retentive aggregate. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel particles.

摘要翻译： 本发明涉及一种形成凝胶颗粒的形状保持性聚集体的方法，其中聚集体通过非共价键的物理力例如但不限于疏水 - 亲水相互作用和氢键保持在一起。 该方法包括将凝胶颗粒悬浮液以选定浓度的极性液体（其中凝胶颗粒具有绝对ζ电位）引入凝胶颗粒的绝对ζ电位降低的介质中，导致凝胶颗粒聚结 进入要求保护的形状保持性聚集体。 本发明还涉及形成凝胶颗粒的形状保持性聚集体的方法的用途。

公开(公告)号：US20080228268A1

公开(公告)日：2008-09-18

申请号：US11686902

申请日：2007-03-15

申请人： Kevin F. Shannon ,  John V. St. John ,  Bill C. Ponder

发明人： Kevin F. Shannon ,  John V. St. John ,  Bill C. Ponder

IPC分类号： A61K47/30 ,  A61F2/02 ,  A61K9/00 ,  B01J13/14

CPC分类号： A61L27/52 ,  A61L27/16 ,  C08L33/00

摘要： This invention provides a viscous, shape conforming gel, comprising between about 1% and 50% by weight (dry) of a plurality of polymeric nanoparticles suspended in a liquid or liquids, at least one of which is polar. The plurality of polymeric nanoparticles contained in the gel have an average diameter of less than 1 micrometer and are comprised of an effective amount of polymeric strands each of which is obtained by polymerization of an effective amount of a monomer or two or more monomers in a polar liquid or a mixture of two or more miscible liquids, at least one of which is polar, and an effective amount of a surfactant to stabilize the plurality of gel particles, thereby forming a suspension of gel particles.

摘要翻译： 本发明提供一种粘稠的形状符合凝胶，其包含悬浮在液体或液体中的多个聚合物纳米颗粒的重量的约1％至50％（干），其中至少一种是极性的。 包含在凝胶中的多个聚合物纳米颗粒具有小于1微米的平均直径，并且由有效量的聚合物链组成，每个聚合物链通过有效量的单体或两种或更多种极性单体的聚合而获得 液体或两种或更多种可混溶液体的混合物，其中至少一种是极性的，以及有效量的表面活性剂以稳定多种凝胶颗粒，从而形成凝胶颗粒的悬浮液。