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    Method of Formation of Viscous, Shape Conforming Gels and Their Uses as Medical Prosthesis
    2.
    发明申请
    Method of Formation of Viscous, Shape Conforming Gels and Their Uses as Medical Prosthesis 审中-公开
    形成凝胶凝胶及其用途作为医疗假体的方法

    公开(公告)号：US20080228268A1

    公开(公告)日：2008-09-18

    申请号：US11686902

    申请日：2007-03-15

    申请人： Kevin F. Shannon ,  John V. St. John ,  Bill C. Ponder

    发明人： Kevin F. Shannon ,  John V. St. John ,  Bill C. Ponder

    IPC分类号： A61K47/30 ,  A61F2/02 ,  A61K9/00 ,  B01J13/14

    CPC分类号： A61L27/52 ,  A61L27/16 ,  C08L33/00

    摘要： This invention provides a viscous, shape conforming gel, comprising between about 1% and 50% by weight (dry) of a plurality of polymeric nanoparticles suspended in a liquid or liquids, at least one of which is polar. The plurality of polymeric nanoparticles contained in the gel have an average diameter of less than 1 micrometer and are comprised of an effective amount of polymeric strands each of which is obtained by polymerization of an effective amount of a monomer or two or more monomers in a polar liquid or a mixture of two or more miscible liquids, at least one of which is polar, and an effective amount of a surfactant to stabilize the plurality of gel particles, thereby forming a suspension of gel particles.

    摘要翻译： 本发明提供一种粘稠的形状符合凝胶，其包含悬浮在液体或液体中的多个聚合物纳米颗粒的重量的约1％至50％（干），其中至少一种是极性的。 包含在凝胶中的多个聚合物纳米颗粒具有小于1微米的平均直径，并且由有效量的聚合物链组成，每个聚合物链通过有效量的单体或两种或更多种极性单体的聚合而获得 液体或两种或更多种可混溶液体的混合物，其中至少一种是极性的，以及有效量的表面活性剂以稳定多种凝胶颗粒，从而形成凝胶颗粒的悬浮液。

    N,O-amidomalonate platinum complexes
    4.
    发明授权
    N,O-amidomalonate platinum complexes 失效
    N，O-酰氨基马来酸盐铂络合物

    公开(公告)号：US06692734B2

    公开(公告)日：2004-02-17

    申请号：US09755220

    申请日：2001-01-04

    申请人： Donald R. Stewart ,  John R. Rice ,  John V. St. John

    发明人： Donald R. Stewart ,  John R. Rice ,  John V. St. John

    IPC分类号： A61K3174

    CPC分类号： C07F15/0093 ,  A61K47/58

    摘要： The present invention relates to purified platinum complexes in which platinum is coordinated to form a single N,O- or O,O-chelate of an amidomalonate. The chelates, and pharmaceutically acceptable formulations thereof, are useful for the treatment of cancer. The platinum chelates may additionally be linked to one or more functional groups which increases water solubility and/or assists in tumor targeting of the chelate. Examples of tumor targeting moieties include polymers, in which one or more platinum chelates are attached to the polymer backbone via linkers capable of being cleaved in the body, and molecules with a high affinity for receptors which are concentrated or upregulated in tumor tissue and/or the tumor vasculature.

    摘要翻译： 本发明涉及铂络合物，其中铂被配位形成酰胺二酸单体的单一N，O-或O，O-螯合物。 螯合物及其药学上可接受的制剂可用于治疗癌症。 铂螯合物还可以连接到增加水溶性的一个或多个官能团和/或有助于螯合物的肿瘤靶向。 肿瘤靶向部分的实例包括聚合物，其中一种或多种铂螯合物通过能够在体内切割的接头连接到聚合物主链上，以及对在肿瘤组织中浓缩或上调的受体具有高亲和力的分子和/或 肿瘤脉管系统。