公开(公告)号：US07351430B2

公开(公告)日：2008-04-01

申请号：US10289756

申请日：2002-11-06

申请人： John V. St. John ,  Daniel G. Moro ,  Bill C. Ponder

发明人： John V. St. John ,  Daniel G. Moro ,  Bill C. Ponder

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  G02C7/04

CPC分类号： A61L27/54 ,  A61K9/5138 ,  A61L27/52 ,  A61L2300/102 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/44 ,  A61L2300/602 ,  C08F220/06 ,  C08F220/28 ,  C08F220/34 ,  C08F222/1006 ,  C08L33/14 ,  C08L71/00 ,  C08L2312/00 ,  Y10T442/2525 ,  C08L2666/16

摘要： The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.

摘要翻译： 本发明涉及由其形成的水凝胶颗粒和聚集体，其特征包括但不限于形状保持性，弹性，可控的孔径和可控的降解速率，使其可用于各种应用，包括但不限于受控释放 生物活性物质，体内医疗器械，组织生长脚手架和组织置换。

公开(公告)号：US5177154A

公开(公告)日：1993-01-05

申请号：US693833

申请日：1991-04-30

申请人： Daniel G. Moro

发明人： Daniel G. Moro

IPC分类号： C08F8/44 ,  C08F220/28

CPC分类号： C08F220/28 ,  C08F8/44

摘要： A water compatible terpolymer for sealing and coating building materials which protects surfaces from environmental staining agents. The terpolymer is created by polymerizing a HEMA:SMA co-polymer with another monomer which contains either free acid or base groups. The resultant terpolymer is water solution after neutralization. Water is then added to bring the solvent level to 40% maximum and the solids level to 8%.

摘要翻译： 用于密封和涂覆建筑材料的水相容三元共聚物，可保护表面免受环境污染。 三元共聚物是通过将HEMA：SMA共聚物与含有游离酸或碱基的另一种单体聚合而产生的。 所得三元共聚物是中和后的水溶液。 然后加入水使溶剂水平达到最大40％，固体含量达到8％。

公开(公告)号：US5045266A

公开(公告)日：1991-09-03

申请号：US430839

申请日：1989-11-02

申请人： Daniel G. Moro ,  Samuel H. Ronel ,  Petr Kuzma

发明人： Daniel G. Moro ,  Samuel H. Ronel ,  Petr Kuzma

IPC分类号： C08F265/04 ,  H04R25/00

CPC分类号： H04R25/658 ,  C08F265/04 ,  H04R25/652 ,  Y10S264/30

摘要： An acoustically sealed earmold for a hearing aid insertable into the ear of individuals with impaired hearing can be prepared in situ employing the hydrophilic composite polymer materials described herein. Such composite materials include at least one hydrophilic polymer in a powder form and one or more liquid components of which at least one is hydrophilic and which can be polymerized with said hydrophilic polymer. The resulting earmold has a shape-retaining, non-tacky flexible consistency which allows it to be shaped further and also to be modified to accommodate a receiver adapter or external receiver. The earmold can then be cured by any of the conventional curing methods to retain its shape permanently. This method enables an audiologist to fit the earmold and evaluate the hearing aid in a single office visit.

摘要翻译： 用于助听器的声学密封耳塞可以被插入到具有受损听力的个人的耳朵中，可以原位使用本文所述的亲水性复合聚合物材料来制备。 这种复合材料包括至少一种粉末形式的亲水性聚合物和一种或多种液体组分，其至少一种是亲水性的并且可与所述亲水性聚合物聚合。 所得到的电子书具有形状保持性，非粘性的柔性一致性，其允许其进一步成形并且还被修改以容纳接收器适配器或外部接收器。 然后可以通过任何常规固化方法固化该耳朵以永久保持其形状。 这种方法使得听力学家能够在单次访问中适应艾玛尔并评估助听器。

公开(公告)号：US07910135B2

公开(公告)日：2011-03-22

申请号：US11581049

申请日：2006-10-13

申请人： John St. John ,  Daniel G. Moro

发明人： John St. John ,  Daniel G. Moro

IPC分类号： A61K9/14 ,  A61K35/00 ,  A61F2/00 ,  A61K38/00 ,  A61K31/715 ,  A61K31/65 ,  A61K31/167 ,  A61K31/7048 ,  A61K31/497 ,  A61F13/00 ,  A01N37/18 ,  A01N37/22 ,  A01N43/16

CPC分类号： A61L26/0061 ,  A61L26/0014 ,  A61L2400/12 ,  Y10S977/906 ,  C08L33/08

摘要： The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

摘要翻译： 本发明涉及形成保持性和形状一致性的聚集伤口敷料和由凝胶纳米颗粒和伤口或体液组成的生物材料的方法，其中聚集体通过非共价键物理力保持在一起，例如但不限于， 疏水 - 亲水相互作用和氢键。 该方法包括将干燥的凝胶纳米颗粒粉末引入伤口部位，其中纳米颗粒吸收一些血液或伤口渗出物，并原位聚结成要求保护的形状保持性骨料敷料。 该方法还包括将体内干燥的纳米颗粒粉末引入湿身体组织中以形成所要求保护的形状保持性生物材料。 此外，该方法还包括结合生物医学剂以产生用于各种医疗应用的药物骨料敷料或生物材料。 本发明还涉及形成凝胶纳米颗粒形状保持性聚集体的方法的用途。

公开(公告)号：US20090196936A1

公开(公告)日：2009-08-06

申请号：US11581049

申请日：2006-10-13

申请人： John ST. John ,  Daniel G. Moro

发明人： John ST. John ,  Daniel G. Moro

IPC分类号： A61K9/14 ,  A61K35/12 ,  A61P17/02 ,  A61K38/02 ,  A61K31/715 ,  A61K31/164 ,  A61K31/7048 ,  A61K31/65 ,  A61K31/496 ,  A61K38/18

CPC分类号： A61L26/0061 ,  A61L26/0014 ,  A61L2400/12 ,  Y10S977/906 ,  C08L33/08

摘要： The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

摘要翻译： 本发明涉及形成保持性和形状一致性的聚集伤口敷料和由凝胶纳米颗粒和伤口或体液组成的生物材料的方法，其中聚集体通过非共价键物理力保持在一起，例如但不限于， 疏水 - 亲水相互作用和氢键。 该方法包括将干燥的凝胶纳米颗粒引入到伤口部位，其中纳米颗粒吸收一些血液或伤口渗出物，并原位聚结成要求保护的形状保持性骨料敷料。 该方法还包括将体内干燥的纳米颗粒粉末引入湿身体组织中以形成所要求保护的形状保持性生物材料。 此外，该方法还包括结合生物医学剂以产生用于各种医疗应用的药物骨料敷料或生物材料。 本发明还涉及形成凝胶纳米颗粒形状保持性聚集体的方法的用途。

公开(公告)号：US20080166409A1

公开(公告)日：2008-07-10

申请号：US11929534

申请日：2007-10-30

申请人： John V. St. John ,  Daniel G. Moro ,  Bill C. Ponder

发明人： John V. St. John ,  Daniel G. Moro ,  Bill C. Ponder

IPC分类号： A61K9/10

CPC分类号： A61L27/54 ,  A61K9/5138 ,  A61L27/52 ,  A61L2300/102 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/44 ,  A61L2300/602 ,  C08F220/06 ,  C08F220/28 ,  C08F220/34 ,  C08F222/1006 ,  C08L33/14 ,  C08L71/00 ,  C08L2312/00 ,  Y10T442/2525 ,  C08L2666/16

摘要： The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.

摘要翻译： 本发明涉及由其形成的水凝胶颗粒和聚集体，其特征包括但不限于形状保持性，弹性，可控的孔径和可控的降解速率，使其可用于各种应用，包括但不限于受控释放 生物活性物质，体内医疗器械，组织生长脚手架和组织置换。

公开(公告)号：US5468811A

公开(公告)日：1995-11-21

申请号：US295357

申请日：1994-08-24

申请人： Daniel G. Moro ,  Samuel H. Ronel ,  Petr Kuzma

发明人： Daniel G. Moro ,  Samuel H. Ronel ,  Petr Kuzma

IPC分类号： A61L9/04 ,  A61L15/12 ,  A61L24/04 ,  A61L24/06 ,  A61L27/16 ,  C08F265/04 ,  A61L15/16 ,  A61L15/07 ,  A61L15/24 ,  C08F265/06

CPC分类号： A61L27/16 ,  A61L15/12 ,  A61L24/04 ,  A61L24/06 ,  A61L9/042 ,  C08F265/04

摘要： Hydrophilic composite polymer articles are provided which comprise at least one hydrophilic polymer in a powder form and one or more liquid components of which at least one is hydrophilic and which can be polymerized with said hydrophilic polymer. This composition is produced from a homogeneously mixed paste which can be molded or cast into a desired shape which will subsequently set. The resulting article has a shape-retaining, non-tacky flexible consistency which allows the shape to be further modified, if necessary.Such object can be then cured by any of the conventional curing methods to retain its shape permanently. The final properties of the composite can be tailored to suit the final application by using fillers or modifiers. In the medical field, such articles can be utilized as a sustained release devices as they can be loaded with the desired therapeutic drugs. These articles can be made non-toxic and biocompatible and used as prosthetic devices.The final cured article can be modified further by polishing, drilling, cutting, etc. When exposed to moisture or a humid environment, the article will become partially hydrated with a resultant softer surface yet retain good mechanical strength.

摘要翻译： 提供了亲水性复合聚合物制品，其包括至少一种粉末形式的亲水性聚合物和一种或多种液体组分，其至少一种是亲水性的，并且可与所述亲水性聚合物聚合。 该组合物由均匀混合的浆料制成，其可以模塑或浇铸成随后固化的所需形状。 所得制品具有形状保持性，非粘性柔性稠度，如果需要，允许形状进一步修饰。 然后可以通过任何常规的固化方法固化该物体以永久地保持其形状。 复合材料的最终性能可以通过使用填料或改性剂进行定制，以适应最终的应用。 在医疗领域中，这些制品可用作持续释放装置，因为它们可以装载所需的治疗药物。 这些制品可以制成无毒和生物兼容并用作假肢装置。 最终的固化制品可以通过抛光，钻孔，切割等进一步改进。当暴露于潮湿或潮湿的环境中时，制品将变得部分水合，得到较软的表面，但仍保持良好的机械强度。

公开(公告)号：US5292515A

公开(公告)日：1994-03-08

申请号：US41523

申请日：1993-03-31

申请人： Daniel G. Moro ,  Petr Kuzma ,  Harry Quandt

发明人： Daniel G. Moro ,  Petr Kuzma ,  Harry Quandt

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61M31/00 ,  B29C41/04 ,  B29C41/50 ,  A61M5/178

CPC分类号： A61K9/0092 ,  A61K9/0024 ,  A61M31/002 ,  A61M37/0069 ,  B29C41/042 ,  B29C41/50

摘要： A method of preparing a hydrophilic plastic cartridge by centrifugally cang polymerizable hydrophilic material in a rotating polymerization tube whose longitudinal axis is maintained parallel to the ground. The speed of rotation causes radial outward displacement of the polymerizable material which upon assuming a predetermined shape within the rotating tube is then polymerized to the predetermined solid configuration. The resulting plastic cartridge is characterized by smooth, unscored internal and external cylindrical surfaces. The cartridges are used as a rate-limiting membrane in drug delivery devices. Sterilized kits containing a disposable needle/syringe or trocar-like instrument and the drug delivery device are used for subcutaneous implantation of the device in an animal body.

摘要翻译： 一种通过在可旋转的聚合管中离心浇铸可聚合的亲水材料制备亲水性塑料盒的方法，该旋转聚合管的纵轴保持平行于地面。 旋转速度导致聚合材料的径向向外位移，其在旋转管内假定预定形状之后，然后聚合成预定的固体构型。 所得到的塑料盒的特征在于平滑的，未刻痕的内部和外部圆柱形表面。 药筒用作药物递送装置中的限速膜。 包含一次性针/注射器或套管针状器械的灭菌药盒和药物递送装置用于将装置皮下植入动物体内。

公开(公告)号：US5266325A

公开(公告)日：1993-11-30

申请号：US621346

申请日：1990-12-03

申请人： Petr Kuzma ,  Daniel G. Moro ,  Harry Quandt

发明人： Petr Kuzma ,  Daniel G. Moro ,  Harry Quandt

IPC分类号： A61K9/00 ,  A61M5/178

CPC分类号： A61K9/0092

摘要： A method is provided for the preparation of homogeneous copolymers having aredetermined equilibrium water content (EWC) value formed by the addition polymerization of a mixture of ethylenically unsaturated monomer A and ethylenically unsaturated monomer B, for example, 2-hydroxyethyl methacrylate and hydroxypropyl methacrylate. The method requires determining the EWC values of the hydrogel homopolymer of hydrophilic monomer A (homopolymer A) and the hydrogel homopolymer of hydrophilic monomer B (homopolymer B); determining the relationship of the EWC values of the homogeneous copolymers AB versus the chemical composition of said copolymers AB; selecting the targeted EWC value and determining the chemical composition of copolymer AB having the targeted EWC value; forming a polymerizable mixture of monomer A and monomer B in amounts sufficient to yield copolymer AB having the targeted EWC value; and effect the polymerization reaction to yield copolymer AB characterized by the targeted EWC value. A method is also provided for the preparation of a delivery device including a drug contained in the reservoir of the hydrogel of copolymer AB, said device being characterized by its capability of eluting or releasing the drug through the hydrogel membrane to a delivery environment at a predetermined rate. There is also disclosed a sterilized kit containing a trocar or hypodermic needle/syringe and the aforesaid drug delivery device having a cylindrical shape with a rounded or bullet-like extremity.

摘要翻译： 提供了通过烯属不饱和单体A和烯属不饱和单体B的混合物例如甲基丙烯酸2-羟乙酯和甲基丙烯酸羟丙酯的加成聚合制备具有预定平衡水含量（EWC）值的均相共聚物的方法。 该方法需要测定亲水性单体A（均聚物A）和亲水性单体B（均聚物B）的水凝胶均聚物的水凝胶均聚物的EWC值。 确定均相共聚物AB的EWC值与所述共聚物AB的化学组成的关系; 选择目标EWC值并确定具有目标EWC值的共聚物AB的化学组成; 以足以产生具有目标EWC值的共聚物AB的量形成单体A和单体B的可聚合混合物; 并进行聚合反应，得到以目标EWC值为特征的共聚物AB。 还提供了一种用于制备包含在共聚物AB的水凝胶的储存器中的药物的递送装置的方法，所述装置的特征在于其能够通过水凝胶膜将药物以预定的方式洗脱或释放到递送环境 率。 还公开了一种含有套管针或皮下注射针/注射器的灭菌试剂盒，上述药物输送装置具有圆形或子弹状末端的圆柱形形状。

公开(公告)号：US20110123621A1

公开(公告)日：2011-05-26

申请号：US12901390

申请日：2010-10-08

申请人： John St. John ,  Daniel G. Moro

发明人： John St. John ,  Daniel G. Moro

IPC分类号： A61K9/14 ,  A61K31/765 ,  A61P17/02

CPC分类号： A61L26/0061 ,  A61L26/0014 ,  A61L2400/12 ,  Y10S977/906 ,  C08L33/08

摘要： The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

摘要翻译： 本发明涉及形成保持性和形状一致性的聚集伤口敷料和由凝胶纳米颗粒和伤口或体液组成的生物材料的方法，其中聚集体通过非共价键物理力保持在一起，例如但不限于， 疏水 - 亲水相互作用和氢键。 该方法包括将干燥的凝胶纳米颗粒引入到伤口部位，其中纳米颗粒吸收一些血液或伤口渗出物，并原位聚结成要求保护的形状保持性骨料敷料。 该方法还包括将体内干燥的纳米颗粒粉末引入湿身体组织中以形成所要求保护的形状保持性生物材料。 此外，该方法还包括结合生物医学剂以产生用于各种医疗应用的药物骨料敷料或生物材料。 本发明还涉及形成凝胶纳米颗粒形状保持性聚集体的方法的用途。