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    FLUORESCENT PARTICLES COMPRISING NANOSCALE ZnO LAYER AND EXHIBITING CELL-SPECIFIC TOXICITY
    2.
    发明申请
    FLUORESCENT PARTICLES COMPRISING NANOSCALE ZnO LAYER AND EXHIBITING CELL-SPECIFIC TOXICITY 失效
    包含纳米ZnO层和展示细胞特异性毒性的荧光颗粒

    公开(公告)号：US20090137666A1

    公开(公告)日：2009-05-28

    申请号：US12235575

    申请日：2008-09-22

    申请人： Hua Wang ,  Denise Wingett ,  Kevin Feris ,  Madhusudan R. Kongara ,  Alex Punnoose

    发明人： Hua Wang ,  Denise Wingett ,  Kevin Feris ,  Madhusudan R. Kongara ,  Alex Punnoose

    IPC分类号： A61K31/315 ,  B05D3/00 ,  A61P31/04

    CPC分类号： A61K49/0043 ,  A61K31/315 ,  A61K49/0093 ,  B82Y5/00 ,  B82Y20/00 ,  B82Y30/00 ,  Y02A50/473 ,  Y10S977/701 ,  Y10S977/712 ,  Y10S977/715

    摘要： Multifunctional “smart” nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO2 core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO2-FITC core. These ˜200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations ≧250-500 μg/mL (for Staphylococcus aureus and Escherichia coli, respectively). These results indicate that the FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.

    摘要翻译： 公开了多功能“智能”纳米结构，其包括具有纳米尺度ZnO整理层的异氰酸荧光素（FITC） - 包封的SiO2核 - 壳颗粒，其中在SiO 2 -FFTC芯上形成外部ZnO层。 这些〜200nm大小的颗粒分别显示使用细菌大肠杆菌和Jurkat癌细胞的细胞成像和细胞摄取研究的希望。 FITC封装的ZnO颗粒显示出优异的杀死Jurkat癌细胞的选择性，对正常的初级免疫细胞具有最小的毒性（分别为暴露于60μg/ mL后分别为18％和75％存活率），并抑制革兰氏阳性 和浓度> 250-500 mug / mL的革兰阴性菌（分别用于金黄色葡萄球菌和大肠杆菌）。 这些结果表明，具有纳米尺度ZnO表面层的FITC封装的多功能颗粒可用作微粒跟踪，细胞成像，抗菌治疗和癌症治疗的智能纳米结构。

    Fluorescent particles comprising nanoscale ZnO layer and exhibiting cell-specific toxicity
    4.
    发明授权
    Fluorescent particles comprising nanoscale ZnO layer and exhibiting cell-specific toxicity 失效
    荧光颗粒包含纳米尺度的ZnO层并显示细胞特异性毒性

    公开(公告)号：US07939560B2

    公开(公告)日：2011-05-10

    申请号：US12235575

    申请日：2008-09-22

    申请人： Hua Wang ,  Denise Wingett ,  Kevin Feris ,  Madhusudan R Kongara ,  Alex Punnoose

    发明人： Hua Wang ,  Denise Wingett ,  Kevin Feris ,  Madhusudan R Kongara ,  Alex Punnoose

    IPC分类号： A61K31/315 ,  A61K9/28

    CPC分类号： A61K49/0043 ,  A61K31/315 ,  A61K49/0093 ,  B82Y5/00 ,  B82Y20/00 ,  B82Y30/00 ,  Y02A50/473 ,  Y10S977/701 ,  Y10S977/712 ,  Y10S977/715

    摘要： Multifunctional “smart” nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO2 core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO2-FITC core. These ˜200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations ≧250-500 μg/mL (for Staphylococcus aureus and Escherichia coli, respectively). These results indicate that the FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.

    摘要翻译： 公开了多功能“智能”纳米结构，其包括具有纳米尺度ZnO整理层的异氰酸荧光素（FITC） - 包封的SiO2核 - 壳颗粒，其中在SiO 2 -FFTC芯上形成外部ZnO层。 这些〜200nm大小的颗粒分别显示出使用细菌大肠杆菌和Jurkat癌细胞的细胞成像和细胞摄取研究的希望。 FITC封装的ZnO颗粒在优先杀死Jurkat癌细胞中具有优异的选择性，对正常的初级免疫细胞具有最小的毒性（暴露于60μg/ mL后分别为18％和75％的活力），并抑制革兰氏阳性 和浓度为250-500μg/ mL的革兰氏阴性细菌（分别用于金黄色葡萄球菌和大肠杆菌）。 这些结果表明，具有纳米尺度ZnO表面层的FITC封装的多功能颗粒可用作微粒跟踪，细胞成像，抗菌治疗和癌症治疗的智能纳米结构。

    ULTRAVIOLET RADIATION PRE-TREATMENT OF WASTEWATER, IMPROVING ITS UTILITY FOR ALGAL CULTIVATION
    5.
    发明申请
    ULTRAVIOLET RADIATION PRE-TREATMENT OF WASTEWATER, IMPROVING ITS UTILITY FOR ALGAL CULTIVATION 审中-公开
    超声波辐射预处理废水，改善其对ALGAL生长的实用性

    公开(公告)号：US20150275166A1

    公开(公告)日：2015-10-01

    申请号：US14667893

    申请日：2015-03-25

    申请人： Kevin Feris ,  Maxine Prior

    发明人： Kevin Feris ,  Maxine Prior

    IPC分类号： C12N1/12 ,  C02F3/32 ,  C12M1/00 ,  C02F1/32

    CPC分类号： C12N1/12 ,  C02F1/001 ,  C02F1/281 ,  C02F1/283 ,  C02F1/32 ,  C02F1/36 ,  C02F1/44 ,  C02F1/78 ,  C02F3/322 ,  C02F2101/105 ,  C02F2101/16 ,  C02F2103/20 ,  C02F2103/22 ,  C02F2103/327 ,  C12N13/00 ,  Y02W10/37

    摘要： The present invention relates to a process of remediating wastewaters, preferably agricultural wastewaters resulting from animal production or contained animal feeding operation sites. The water is treated to promote assimilation of nutrients into algal biomass, which can be harvested and sold, and the resultant wastewater is then purified. According to the invention, short wavelength UV radiation (less than 280 nm wavelength) is used to pretreat wastewater, with the dose determined by absorbance of the water, not by bacterial load. Pretreated water exhibits changes in chromophoric dissolved organic matter that allows for improved and increased algae production by as much as 88%.

    摘要翻译： 本发明涉及一种补救废水，优选由动物生产产生的农业废水或含有动物饲养操作场所的方法。 处理水以促进营养物质同化到藻类生物质中，其可以被收获和销售，然后纯化所得废水。 根据本发明，使用短波长紫外辐射（小于280nm波长）来预处理废水，其剂量由水的吸光度决定，而不是细菌负荷。 预处理的水表现出发色体溶解的有机物质的变化，允许藻类生产的提高和增加高达88％。