公开(公告)号：US20080227777A1

公开(公告)日：2008-09-18

申请号：US11961282

申请日：2007-12-20

申请人： Henning STEINHAGEN ,  Jochen HUBER ,  Kurt RITTER ,  Bernard PIRARD ,  Kirsten BJERGARDE ,  Marcel PATEK ,  Martin SMRCINA ,  Linli WEI

发明人： Henning STEINHAGEN ,  Jochen HUBER ,  Kurt RITTER ,  Bernard PIRARD ,  Kirsten BJERGARDE ,  Marcel PATEK ,  Martin SMRCINA ,  Linli WEI

IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61P31/12 ,  A61P25/36 ,  A61K31/437

CPC分类号： C07D471/04

摘要： The invention relates to 6-amido substituted pyrazolopyridine derivatives of the formula (I) useful as inhibitors of beta-adrenergic receptor kinase 1 (βARK-1), compositions containing such compounds and their use for the treatment and prevention of chronic heart failure, hypertension, myocardial ischemia and hepatitis C virus (HCV) infections, and for the prevention of opiate addiction.

摘要翻译： 本发明涉及可用作β-肾上腺素能受体激酶1（βARK-1）抑制剂的式（I）的6-酰氨基取代的吡唑并吡啶衍生物，含有这些化合物的组合物及其用于治疗和预防慢性心力衰竭，高血压的用途 ，心肌缺血和丙型肝炎病毒（HCV）感染，以及预防鸦片成瘾。

公开(公告)号：US07910602B2

公开(公告)日：2011-03-22

申请号：US11961282

申请日：2007-12-20

申请人： Henning Steinhagen ,  Jochen Huber ,  Kurt Ritter ,  Bernard Pirard ,  Kirsten Bjergarde ,  Marcel Patek ,  Martin Smrcina ,  Linli Wei

发明人： Henning Steinhagen ,  Jochen Huber ,  Kurt Ritter ,  Bernard Pirard ,  Kirsten Bjergarde ,  Marcel Patek ,  Martin Smrcina ,  Linli Wei

IPC分类号： A61K31/44 ,  A01N43/42 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02

CPC分类号： C07D471/04

摘要： The invention relates to 6-amido substituted pyrazolopyridine derivatives of the formula (I) useful as inhibitors of beta-adrenergic receptor kinase 1 (βARK-1), compositions containing such compounds and their use for the treatment and prevention of chronic heart failure, hypertension, myocardial ischemia and hepatitis C virus (HCV) infections, and for the prevention of opiate addiction.

摘要翻译： 本发明涉及可用作β-肾上腺素能受体激酶1抑制剂（＆Bgr; ARK-1）的式（I）的6-酰氨基取代的吡唑并吡啶衍生物，含有这些化合物的组合物及其用于治疗和预防慢性心力衰竭 ，高血压，心肌缺血和丙型肝炎病毒（HCV）感染以及预防鸦片成瘾。

公开(公告)号：US07635698B2

公开(公告)日：2009-12-22

申请号：US11320298

申请日：2005-12-28

申请人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

发明人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

IPC分类号： A61K31/497 ,  C07D295/00 ,  C07D241/04

CPC分类号： C07D207/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D487/08 ,  C07D491/10

摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

摘要翻译： 本发明涉及可用作趋化因子受体拮抗剂的化合物。 提供通式I的化合物：或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物以及使用化合物和组合物抑制趋化因子受体的方法，还用于治疗各种疾病，病症或病症，包括急性或慢性炎性疾病，癌症和溶骨性骨 疾病

公开(公告)号：US20060189628A1

公开(公告)日：2006-08-24

申请号：US11320298

申请日：2005-12-28

申请人： Gerard Rosse ,  Linli Wei ,  Kenneth Carson

发明人： Gerard Rosse ,  Linli Wei ,  Kenneth Carson

IPC分类号： A61K31/496 ,  A61K31/4545 ,  C07D403/14 ,  C07D401/14

CPC分类号： C07D207/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D487/08 ,  C07D491/10

摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

公开(公告)号：US08399455B2

公开(公告)日：2013-03-19

申请号：US12577853

申请日：2009-10-13

申请人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

发明人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

IPC分类号： A61K31/55 ,  C07D243/08

CPC分类号： C07D207/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D487/08 ,  C07D491/10

摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

公开(公告)号：US20100234356A1

公开(公告)日：2010-09-16

申请号：US12577853

申请日：2009-10-13

申请人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

发明人： Gerard Rosse ,  Linli Wei ,  Kenneth G. Carson

IPC分类号： A61K31/551 ,  C07D403/04 ,  A61K31/454 ,  C07D401/14 ,  A61K31/496 ,  C07D243/08 ,  A61P9/10 ,  A61P37/06 ,  A61P19/02 ,  A61P11/06 ,  A61P17/06 ,  A61P3/10 ,  C07D403/14

CPC分类号： C07D207/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D487/08 ,  C07D491/10

摘要： The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

摘要翻译： 本发明涉及可用作趋化因子受体拮抗剂的化合物。 提供通式I的化合物：或其药学上可接受的盐。 本发明还提供包含所述化合物的药学上可接受的组合物以及使用化合物和组合物抑制趋化因子受体的方法，还用于治疗各种疾病，病症或病症，包括急性或慢性炎性疾病，癌症和溶骨性骨 疾病