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公开(公告)号：US09642907B2
公开(公告)日：2017-05-09
申请号：US12227250
申请日：2007-05-11
Applicant: Krishna Murthy Ella , Victor Jerusha Augustus Harshavardhan Gutla , Krishna Mohan Vadrevu , Smita Suneel Singhania
Inventor： Krishna Murthy Ella , Victor Jerusha Augustus Harshavardhan Gutla , Krishna Mohan Vadrevu , Smita Suneel Singhania
CPC classification number: A61K39/15 , A61K39/12 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , A61K2039/55505 , C12N7/00 , C12N2720/12334
Abstract: The present invention relates to a composition comprising a viral antigen, a first protein and a second protein. Optionally, the composition also comprises three different disaccharaides, or, optionally, the composition comprises a primary sugar and at least one, preferably two secondary sugars. The present invention also relates to the use of a viral antigen, a first protein and a second protein for the manufacture of a composition, preferably a vaccine. The present invention furthermore relates to a method of treatment or prevention of virus associates diseases in humans. Moreover, the present invention relates to a method of adapting a virus to a suitable cell-line. The invention is also useful for the production of virus suspensions suitable for making stable, live/inactivated, monovalent and/or polyvalent, liquid/lyophilized rotavirus vaccine compositions for oral and/or nasal or any other suitable route of administration in human.
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公开(公告)号：US20100173842A1
公开(公告)日：2010-07-08
申请号：US12575667
申请日：2009-10-08
Applicant: Krishna Murthy ELLA , Kandaswamy SUMATHY , Krishna Mohan VADREVU
Inventor： Krishna Murthy ELLA , Kandaswamy SUMATHY , Krishna Mohan VADREVU
CPC classification number: C07K14/31 , A61K39/00 , A61K2039/53 , C07K16/1271 , G01N33/56938 , G01N2333/31 , G01N2469/20
Abstract: The invention relates to a method of preparation and use of a polypeptide vaccine formulation for prevention and control of Staphylococci mediated infections in human, bovine and other mammals, using recombinant DNA technology.
Abstract translation: 本发明涉及使用重组DNA技术制备和使用多肽疫苗制剂以预防和控制人，牛和其他哺乳动物中葡萄球菌介导的感染的方法。
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Patent Agency Ranking
公开(公告)号：US20100068227A1
公开(公告)日：2010-03-18
申请号：US12227250
申请日：2007-05-11
Applicant: Krishna Murthy Ella , Victor Jerusha Augustus Harshavardhan Gutla , Krishna Mohan Vadrevu , Smita Suneel Singhania
Inventor： Krishna Murthy Ella , Victor Jerusha Augustus Harshavardhan Gutla , Krishna Mohan Vadrevu , Smita Suneel Singhania
CPC classification number: A61K39/15 , A61K39/12 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , A61K2039/55505 , C12N7/00 , C12N2720/12334
Abstract: The present invention relates to a composition comprising a viral antigen, a first protein and a second protein. Optionally, the composition also comprises three different disaccharaides, or, optionally, the composition comprises a primary sugar and at least one, preferably two secondary sugars. The present invention also relates to the use of a viral antigen, a first protein and a second protein for the manufacture of a composition, preferably a vaccine. The present invention furthermore relates to a method of treatment or prevention of virus associates diseases in humans. Moreover, the present invention relates to a method of adapting a virus to a suitable cell-line. The invention is also useful for the production of virus suspensions suitable for making stable, live/inactivated, monovalent and/or polyvalent, liquid/lyophilized rotavirus vaccine compositions for oral and/or nasal or any other suitable route of administration in human.
Abstract translation: 本发明涉及包含病毒抗原，第一蛋白质和第二蛋白质的组合物。 任选地，组合物还包含三种不同的糖苷，或者任选地，组合物包含初级糖和至少一种，优选两种二级糖。 本发明还涉及病毒抗原，第一蛋白质和第二蛋白质用于制备组合物，优选疫苗的用途。 本发明还涉及治疗或预防人类疾病病毒相关疾病的方法。 此外，本发明涉及使病毒适应于合适的细胞系的方法。 本发明还可用于生产适用于制备用于口服和/或鼻或其它合适的人类给药途径的稳定，活/灭活的单价和/或多价液体/冻干轮状病毒疫苗组合物的病毒悬浮液。
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公开(公告)号：US20120107356A1
公开(公告)日：2012-05-03
申请号：US13383629
申请日：2010-01-25
Applicant: Krishna Mohan Vadrevu , Selvi Veerabadran , Sai Devarajulu Prasad
Inventor： Krishna Mohan Vadrevu , Selvi Veerabadran , Sai Devarajulu Prasad
CPC classification number: C12N7/00 , A61K39/12 , A61K39/15 , A61K2039/5254 , C12N2720/12334 , C12N2720/12351 , C12N2999/007
Abstract: Compositions and methods related to live or live attenuated pre-conditioned and typical viruses such as rotaviruses are disclosed. The live attenuated rotaviruses exhibit better stability characteristics and are useful for the prevention of a rotavirus infection and/or rotavirus gastroenteritis in children.
Abstract translation: 公开了与活或减毒预处理和典型病毒如轮状病毒相关的组合物和方法。 活的减毒轮状病毒表现出更好的稳定性特征，可用于预防儿童轮状病毒感染和/或轮状病毒肠胃炎。
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公开(公告)号：US10568957B2
公开(公告)日：2020-02-25
申请号：US14396691
申请日：2013-04-23
Inventor： Krishna Mohan Vadrevu , Sai Devarajulu Prasad
Abstract: Invention provides novel rotavirus vaccine compositions comprising rotavirus antigens, stabilizers and buffers. The buffers in the invention are pre-mixed in the rotavirus vaccine compositions to neutralize the high acidic pH of the stomach without requiring separate administration of an antacid before vaccine administration. Vaccine compositions with buffers of the invention are stable liquid rotavirus vaccine formulations for oral administration.
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公开(公告)号：US09598676B2
公开(公告)日：2017-03-21
申请号：US13383629
申请日：2010-01-25
Applicant: Krishna Mohan Vadrevu , Selvi Veerabadran , Sai Devarajulu Prasad
Inventor： Krishna Mohan Vadrevu , Selvi Veerabadran , Sai Devarajulu Prasad
IPC: C12N7/02 , A61K39/02 , A61K39/145 , A61K39/155 , A61P37/04 , C12N7/00 , A61K39/15 , A61K39/12 , A61K39/00
CPC classification number: C12N7/00 , A61K39/12 , A61K39/15 , A61K2039/5254 , C12N2720/12334 , C12N2720/12351 , C12N2999/007
Abstract: Compositions and methods related to live or live attenuated pre-conditioned and typical viruses such as rotaviruses are disclosed. The live attenuated rotaviruses exhibit better stability characteristics and are useful for the prevention of a rotavirus infection and/or rotavirus gastroenteritis in children.
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公开(公告)号：US20090220538A1
公开(公告)日：2009-09-03
申请号：US12067458
申请日：2006-07-13
Applicant: Krishna Murthy Ella , Kandaswamy Sumathy , Krishna Mohan Vadrevu
Inventor： Krishna Murthy Ella , Kandaswamy Sumathy , Krishna Mohan Vadrevu
IPC: A61K39/085 , C07K14/195 , C12N15/31 , C12N15/85 , C12P21/02 , A61K31/713 , A61P31/04
CPC classification number: C07K14/31 , A61K39/00 , A61K2039/53
Abstract: The present invention describes method of preparation and use of polypeptide vaccine formulation for prevention and control of Staphylococci mediated infections in human, bovine and other mammals, using recombinant DNA technology.
Abstract translation: 本发明描述了使用重组DNA技术制备和使用多肽疫苗制剂以预防和控制人，牛和其他哺乳动物中葡萄球菌介导的感染的方法。
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