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公开(公告)号：US20090098576A1
公开(公告)日：2009-04-16
申请号：US12252120
申请日：2008-10-15
申请人： Philip Andersen , Melissa Jane Beall , Jesse Buch , Ku-chuan Hsiao , Stacey Pazar Huth , Eugene Regis Krah , Barbara O'Brien , Marilyn Strong-Townsend
发明人： Philip Andersen , Melissa Jane Beall , Jesse Buch , Ku-chuan Hsiao , Stacey Pazar Huth , Eugene Regis Krah , Barbara O'Brien , Marilyn Strong-Townsend
IPC分类号： G01N33/573 , C07K16/18 , C12N5/06
摘要： Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Host cells comprising a vector containing the polynucleotide sequences and methods for expressing the polypeptides. The generation of monoclonal antibodies that specifically binds to the feline pancreatic lipase polypeptides, and cell lines secreting the monoclonal antibodies. Methods for determining the presence or amount of feline pancreatic lipase in a biological sample. The methods include using standards or calibrators of recombinant feline pancreatic lipase to quantify the lipase in a sample. Devices and kits for performing methods for detecting feline pancreatic lipase in biological samples.
摘要翻译： 具有编码猫胰脂肪酶多肽，剪接变体，等位基因变体及其片段的核苷酸序列的分离的核酸分子。 分离的猫胰脂肪酶多肽，剪接变体，等位变体及其片段。 宿主细胞包含含有多核苷酸序列的载体和表达多肽的方法。 特异性结合猫胰脂肪酶多肽的单克隆抗体的产生，以及分泌单克隆抗体的细胞系。 确定生物样品中猫胰脂肪酶的存在或量的方法。 所述方法包括使用重组猫胰脂肪酶的标准品或校准物来定量样品中的脂肪酶。 用于检测生物样品中的猫胰脂肪酶的方法的装置和试剂盒。
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公开(公告)号：US20100267131A1
公开(公告)日：2010-10-21
申请号：US12813068
申请日：2010-06-10
申请人： Philip Andersen , Melissa Jane Beall , Jesse Buch , Ku-chuan Hsiao , Stacey Pazar Huth , Eugene Regis Krash, III , Barbara O'Brien , Marilyn Strong-Townsend
发明人： Philip Andersen , Melissa Jane Beall , Jesse Buch , Ku-chuan Hsiao , Stacey Pazar Huth , Eugene Regis Krash, III , Barbara O'Brien , Marilyn Strong-Townsend
摘要： Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Host cells comprising a vector containing the polynucleotide sequences and methods for expressing the polypeptides. The generation of monoclonal antibodies that specifically binds to the feline pancreatic lipase polypeptides, and cell lines secreting the monoclonal antibodies. Methods for determining the presence or amount of feline pancreatic lipase in a biological sample. The methods include using standards or calibrators of recombinant feline pancreatic lipase to quantify the lipase in a sample. Devices and kits for performing methods for detecting feline pancreatic lipase in biological samples.
摘要翻译： 具有编码猫胰脂肪酶多肽，剪接变体，等位基因变体及其片段的核苷酸序列的分离的核酸分子。 分离的猫胰脂肪酶多肽，剪接变体，等位变体及其片段。 宿主细胞包含含有多核苷酸序列的载体和表达多肽的方法。 特异性结合猫胰脂肪酶多肽的单克隆抗体的产生，以及分泌单克隆抗体的细胞系。 确定生物样品中猫胰脂肪酶的存在或量的方法。 所述方法包括使用重组猫胰脂肪酶的标准品或校准物来定量样品中的脂肪酶。 用于检测生物样品中的猫胰脂肪酶的方法的装置和试剂盒。
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公开(公告)号：US07771960B2
公开(公告)日：2010-08-10
申请号：US12252120
申请日：2008-10-15
申请人： Philip Andersen , Melissa Jane Beall , Jesse Buch , Ku-chuan Hsiao , Stacey Pazar Huth , Eugene Regis , Barbara O'Brien , Marilyn Strong-Townsend
发明人： Philip Andersen , Melissa Jane Beall , Jesse Buch , Ku-chuan Hsiao , Stacey Pazar Huth , Eugene Regis , Barbara O'Brien , Marilyn Strong-Townsend
IPC分类号： G01N33/573 , G01N33/53 , C07K16/18
摘要： Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Host cells comprising a vector containing the polynucleotide sequences and methods for expressing the polypeptides. The generation of monoclonal antibodies that specifically binds to the feline pancreatic lipase polypeptides, and cell lines secreting the monoclonal antibodies. Methods for determining the presence or amount of feline pancreatic lipase in a biological sample. The methods include using standards or calibrators of recombinant feline pancreatic lipase to quantify the lipase in a sample. Devices and kits for performing methods for detecting feline pancreatic lipase in biological samples.
摘要翻译： 具有编码猫胰脂肪酶多肽，剪接变体，等位基因变体及其片段的核苷酸序列的分离的核酸分子。 分离的猫胰脂肪酶多肽，剪接变体，等位变体及其片段。 宿主细胞包含含有多核苷酸序列的载体和表达多肽的方法。 特异性结合猫胰脂肪酶多肽的单克隆抗体的产生，以及分泌单克隆抗体的细胞系。 确定生物样品中猫胰脂肪酶的存在或量的方法。 所述方法包括使用重组猫胰脂肪酶的标准品或校准物来定量样品中的脂肪酶。 用于检测生物样品中的猫胰脂肪酶的方法的装置和试剂盒。
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公开(公告)号：US20090053807A1
公开(公告)日：2009-02-26
申请号：US11949153
申请日：2007-12-03
申请人： Renuka Pillutla , Olga Dedova , Arthur J. Blume , Neil I. Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-chuan Hsiao , Michael Lennick , Paul Fletcher
发明人： Renuka Pillutla , Olga Dedova , Arthur J. Blume , Neil I. Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-chuan Hsiao , Michael Lennick , Paul Fletcher
IPC分类号： C12N5/06
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
摘要翻译： 公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。 本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。 作为激动剂，本发明的肽可用于开发作为补充或代替内源肽激素的治疗剂。 拮抗剂肽也可以作为治疗剂开发。
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公开(公告)号：US20070004634A1
公开(公告)日：2007-01-04
申请号：US11410222
申请日：2006-04-24
申请人： Renuka Pillutla , Olga Dedova , Arthur Blume , Neil Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-chuan Hsiao , Michael Lennick , Paul Fletcher
发明人： Renuka Pillutla , Olga Dedova , Arthur Blume , Neil Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-chuan Hsiao , Michael Lennick , Paul Fletcher
IPC分类号： A61K38/08
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
摘要翻译： 公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。 本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。 作为激动剂，本发明的肽可用于开发作为补充或代替内源肽激素的治疗剂。 拮抗剂肽也可以作为治疗剂开发。
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公开(公告)号：US08138316B2
公开(公告)日：2012-03-20
申请号：US12813068
申请日：2010-06-10
申请人： Philip Andersen , Melissa Jane Beall , Jesse Buch , Ku-chuan Hsiao , Stacey Pazar Huth , Eugene Regis Krah, III , Barbara O'Brien , Marilyn Strong-Townsend
发明人： Philip Andersen , Melissa Jane Beall , Jesse Buch , Ku-chuan Hsiao , Stacey Pazar Huth , Eugene Regis Krah, III , Barbara O'Brien , Marilyn Strong-Townsend
摘要： Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Host cells comprising a vector containing the polynucleotide sequences and methods for expressing the polypeptides. The generation of monoclonal antibodies that specifically binds to the feline pancreatic lipase polypeptides, and cell lines secreting the monoclonal antibodies. Methods for determining the presence or amount of feline pancreatic lipase in a biological sample. The methods include using standards or calibrators of recombinant feline pancreatic lipase to quantify the lipase in a sample. Devices and kits for performing methods for detecting feline pancreatic lipase in biological samples.
摘要翻译： 具有编码猫胰脂肪酶多肽，剪接变体，等位基因变体及其片段的核苷酸序列的分离的核酸分子。 分离的猫胰脂肪酶多肽，剪接变体，等位变体及其片段。 宿主细胞包含含有多核苷酸序列的载体和表达多肽的方法。 特异性结合猫胰脂肪酶多肽的单克隆抗体的产生，以及分泌单克隆抗体的细胞系。 确定生物样品中猫胰脂肪酶的存在或量的方法。 所述方法包括使用重组猫胰脂肪酶的标准品或校准物来定量样品中的脂肪酶。 用于检测生物样品中的猫胰脂肪酶的方法的装置和试剂盒。
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公开(公告)号：US07173005B2
公开(公告)日：2007-02-06
申请号：US10253493
申请日：2002-09-24
申请人： Renuka Pillutla , Olga Dedova , Arthur J. Blume , Neil I. Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-Chuan Hsiao , Michael Lennick , Paul Fletcher
发明人： Renuka Pillutla , Olga Dedova , Arthur J. Blume , Neil I. Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-Chuan Hsiao , Michael Lennick , Paul Fletcher
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
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