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公开(公告)号：US20070004634A1
公开(公告)日：2007-01-04
申请号：US11410222
申请日：2006-04-24
申请人： Renuka Pillutla , Olga Dedova , Arthur Blume , Neil Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-chuan Hsiao , Michael Lennick , Paul Fletcher
发明人： Renuka Pillutla , Olga Dedova , Arthur Blume , Neil Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-chuan Hsiao , Michael Lennick , Paul Fletcher
IPC分类号： A61K38/08
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
摘要翻译： 公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。 本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。 作为激动剂，本发明的肽可用于开发作为补充或代替内源肽激素的治疗剂。 拮抗剂肽也可以作为治疗剂开发。
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公开(公告)号：US07173005B2
公开(公告)日：2007-02-06
申请号：US10253493
申请日：2002-09-24
申请人： Renuka Pillutla , Olga Dedova , Arthur J. Blume , Neil I. Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-Chuan Hsiao , Michael Lennick , Paul Fletcher
发明人： Renuka Pillutla , Olga Dedova , Arthur J. Blume , Neil I. Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-Chuan Hsiao , Michael Lennick , Paul Fletcher
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
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公开(公告)号：US20090053807A1
公开(公告)日：2009-02-26
申请号：US11949153
申请日：2007-12-03
申请人： Renuka Pillutla , Olga Dedova , Arthur J. Blume , Neil I. Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-chuan Hsiao , Michael Lennick , Paul Fletcher
发明人： Renuka Pillutla , Olga Dedova , Arthur J. Blume , Neil I. Goldstein , Renee Brissette , Pinger Wang , Hao Liu , Ku-chuan Hsiao , Michael Lennick , Paul Fletcher
IPC分类号： C12N5/06
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
摘要翻译： 公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。 本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。 作为激动剂，本发明的肽可用于开发作为补充或代替内源肽激素的治疗剂。 拮抗剂肽也可以作为治疗剂开发。
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公开(公告)号：US09022747B2
公开(公告)日：2015-05-05
申请号：US13505861
申请日：2010-11-12
申请人： Paul Fletcher , Philip P. Walsh
发明人： Paul Fletcher , Philip P. Walsh
CPC分类号： F04D27/001 , F04B23/04 , F04B41/06 , F04B49/065 , F04D17/14 , F04D27/0215 , F04D27/0246 , F04D27/0261 , F04D27/0269
摘要： A method of compressing a gas, which uses a compressor train having a plurality of discrete portions and including at least an upstream portion, a mid-stream portion and a downstream portion arranged successively in flow series. The method includes: (i) performing a first compression step by directing a flow of said gas into the upstream compressor portion and driving the upstream compressor portion to compress the gas; (ii) performing a second compression step by directing the compressed flow from the upstream compressor portion into the mid-stream compressor portion and driving the mid-stream compressor portion to further compress the gas; and (iii) performing a third compression step by directing the compressed flow from the mid-stream compressor portion into the downstream compressor portion and driving the downstream compressor portion to further compress the gas.
摘要翻译： 一种压缩气体的方法，其使用具有多个离散部分并且包括至少上游部分，中流部分和下游部分的压缩机组，所述中流部分和下游部分依次以流动方式排列。 该方法包括：（i）通过将所述气体的流动引导到上游压缩机部分中并驱动上游压缩机部分来压缩气体来执行第一压缩步骤; （ii）通过将来自上游压缩机部分的压缩流引导到中流压缩机部分中并且驱动中流压缩机部分以进一步压缩气体来执行第二压缩步骤; 和（iii）通过将来自中流压缩机部分的压缩流引导到下游压缩机部分中并且驱动下游压缩机部分进一步压缩气体来执行第三压缩步骤。
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公开(公告)号：US08727823B2
公开(公告)日：2014-05-20
申请号：US13418924
申请日：2012-03-13
申请人： Paul Fletcher , Paul J. Newton , John R. Webster
发明人： Paul Fletcher , Paul J. Newton , John R. Webster
IPC分类号： B63H11/103
CPC分类号： B63H11/04 , B63H2011/043
摘要： There is provided a water jet propulsion device 10 for a water vehicle, comprising a main duct 12 having a main inlet 14 that is arranged to be submerged in use and a main outlet 16; a pump disposed between the main inlet 14 and the main outlet 16; and a plurality of injection nozzles 40, 50, 60, 70 each arranged to selectively eject a jet of fluid into a different region A, B, C, D susceptible to cavitation, so as to re-energise the fluid flow in that region.
摘要翻译： 提供了一种用于水车辆的喷水推进装置10，其包括主管道12，主管道12具有被设置为浸没在使用中的主入口14和主出口16; 设置在主入口14和主出口16之间的泵; 以及多个喷嘴40,50,60,70，每个喷嘴40,50,60,70各自布置成选择性地将流体射流喷射到易于气蚀的不同区域A，B，C，D中，以便在该区域中再次通电流体流。
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公开(公告)号：US20130045079A1
公开(公告)日：2013-02-21
申请号：US13695726
申请日：2011-04-28
IPC分类号： F04D15/00
CPC分类号： F04D27/0261 , F04D27/0269 , F04D27/0276 , F04D27/0284
摘要： An industrial system for compressing a waste gas product, such as CO2, including a compressor train having an upstream rotor portion and a downstream rotor portion arranged in flow series with said upstream portion. Each rotor portion includes one or more compressor stages and said downstream portion is arranged to rotate at a variable relative speed to that of the upstream rotor portion. Sensing equipment for the compressor train is arranged to determine one or more flow conditions and a controller is arranged to receive data indicative of said one or more sensed flow conditions. The controller is arranged to set the rotational speed of the upstream rotor portion based upon the pressure or flow rate of gas upstream of said compressor train and to set operational parameters for said downstream portion so as to maintain a desired surge margin for said upstream rotor portion.
摘要翻译： 一种用于压缩诸如CO 2的废气产品的工业系统，包括具有上游转子部分和与所述上游部分流动串联布置的下游转子部分的压缩机组。 每个转子部分包括一个或多个压缩机级，并且所述下游部分布置成以与上游转子部分相对的可变相对速度旋转。 布置用于压缩机列车的感测设备以确定一个或多个流量条件，并且控制器被布置成接收指示所述一个或多个感测流量条件的数据。 所述控制器被设置成基于所述压缩机组上游的气体的压力或流量来设定所述上游转子部分的转速并设定所述下游部分的操作参数，以保持所述上游转子部分所需的喘振裕度 。
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公开(公告)号：US20110179776A1
公开(公告)日：2011-07-28
申请号：US13057611
申请日：2009-05-29
申请人： Martin Magnusson , Paul Fletcher , Otto Feldner
发明人： Martin Magnusson , Paul Fletcher , Otto Feldner
CPC分类号： B60K13/04 , B60K2015/03039 , B60K2015/03348 , B60K2015/03557 , F01N3/2066 , F01N2610/02 , F01N2610/1406 , F01N2610/1413 , Y02A50/2325
摘要： The invention relates to a tank for working fluids of motor vehicles, comprising a metal wall, at least one opening therein, and a plastic coating on the inside of the metal wall, wherein the plastic coating extends through the opening at least to the level of the outside of the metal wall.
摘要翻译： 本发明涉及一种用于机动车辆的工作流体的罐，包括金属壁，其中的至少一个开口和在金属壁的内侧上的塑料涂层，其中塑料涂层延伸穿过开口至少达到 金属墙外。
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公开(公告)号：US20100132267A1
公开(公告)日：2010-06-03
申请号：US12596983
申请日：2007-04-24
申请人： Paul Fletcher
发明人： Paul Fletcher
CPC分类号： E04H3/14
摘要： An auditorium (10), part of which is covered by a roof structure (20), the auditorium has a partitioning structure (22) which acts to partition off a section of the auditorium whereby a majority part of the partitioned section is covered by the roof structure.
摘要翻译： 礼堂（10），其一部分由屋顶结构（20）覆盖，礼堂具有分隔结构（22），用于分隔礼堂的一部分，由此分隔部分的大部分被 屋顶结构。
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公开(公告)号：US20050159108A1
公开(公告)日：2005-07-21
申请号：US10507449
申请日：2003-03-07
申请人： Paul Fletcher , Michael Dean
发明人： Paul Fletcher , Michael Dean
CPC分类号： H04B7/0848 , H01Q3/2605 , H04B7/0822
摘要： A phased array antenna that employs a switched least means squared architecture comprises plurality of receiving elements each having a respective weighting unit associated therewith, a summation unit, a processor, a plurality of sampling devise and a switching unit contains a switch arm having a contact at its free and, an ADC and a plurality of switch contacts corresponding to the ends of channels connected to the respective sampling devices. Each of a plurality of receiving elements is ampled by a respective sampling device prior to an incoming signal subjected to complex weighting by respective weighting units. Each of the signals sampled by the sampling device passes along respective channels to the switching unit. Thus, by switching between the contacts it is possible to vary which of the receiving elements is sampled. The processor calculates new complex weighting coefficients to be applied to the incoming signals by the weighting units using the sampled incoming signals in order to minimize a difference between an output from the summation unit y and a training signal d.
摘要翻译： 采用切换最小均方平方结构的相控阵天线包括多个接收元件，每个接收元件具有与之相关联的相应加权单元，加法单元，处理器，多个采样设备和切换单元，其包含具有接触的开关臂 其空闲的ADC和多个开关触点对应于连接到相应采样装置的通道的端部。 多个接收元件中的每一个在通过各个加权单元进行复杂加权的输入信号之前由相应的采样设备放大。 由采样装置采样的每个信号都沿着相应的通道传送到切换单元。 因此，通过在触点之间切换，可以改变哪个接收元件被采样。 处理器使用采样的输入信号来计算由加权单元施加到输入信号的新的复加权系数，以便最小化来自求和单元y的输出与训练信号d之间的差。
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公开(公告)号：US06837783B2
公开(公告)日：2005-01-04
申请号：US10138744
申请日：2002-05-03
申请人： Will Hunt-Vincent , Paul Fletcher
发明人： Will Hunt-Vincent , Paul Fletcher
CPC分类号： G07D1/00
摘要： A base for a coin store comprises an essentially planar part for supporting a coin or coins and retaining means for retaining coins within the coin store in use, and the retaining means comprises at least one part extending essentially perpendicular to the planar part of the base.
摘要翻译： 用于硬币存储的基座包括用于支撑硬币或硬币的基本上平面的部分和用于在使用中将硬币保持在硬币存储器内的保持装置，并且保持装置包括基本上垂直于基座的平面部分延伸的至少一个部分。
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