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公开(公告)号：US20060199205A1
公开(公告)日：2006-09-07
申请号：US11357887
申请日：2006-02-17
申请人： Georges Natsoulis , Mark Fielden , Kurt Jarnagin , Kyle Kolaja
发明人： Georges Natsoulis , Mark Fielden , Kurt Jarnagin , Kyle Kolaja
CPC分类号： G01N33/6893 , G01N2500/00 , G01N2800/347
摘要： The invention discloses reagent sets and gene signatures for predicting onset of renal tubule injury in a subject. The invention also provides a necessary set of 186 genes useful for generating signatures of varying size and performance capable of predicting onset of renal tubule injury. The invention also provides methods, apparatuses and reagents useful for predicting future renal tubule injury based on expression levels of genes in the signatures. In one particular embodiment the invention provides a method for predict whether a compound will induce renal tubule injury using gene expression data from sub-acute treatments.
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公开(公告)号：US20120035132A1
公开(公告)日：2012-02-09
申请号：US13015487
申请日：2011-01-27
申请人： Kurt Jarnagin , Tsutomu Akama
发明人： Kurt Jarnagin , Tsutomu Akama
IPC分类号： A61K31/69 , C12N5/071 , A61P17/06 , A61P17/00 , C12N9/99 , A61P33/12 , A61P1/00 , A61P11/06 , A61P11/00 , A61P33/10 , C07F5/02 , A61P29/00
摘要： Compounds, pharmaceutical formulations, and methods of treating anti-inflammatory conditions and/or helminth-associated diseases are disclosed.
摘要翻译： 公开了化合物，药物制剂和治疗抗炎症状和/或蠕虫相关疾病的方法。
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公开(公告)号：US07588892B2
公开(公告)日：2009-09-15
申请号：US11184272
申请日：2005-07-18
申请人： Georges Natsoulis , Mark Fielden , Kurt Jarnagin , Kyle Kolaja
发明人： Georges Natsoulis , Mark Fielden , Kurt Jarnagin , Kyle Kolaja
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , G01N2500/00 , G01N2800/347
摘要： The invention discloses reagent sets and gene signatures for predicting onset of renal tubule injury in a subject. The invention also provides a necessary set of 186 genes useful for generating signatures of varying size and performance capable of predicting onset of renal tubule injury. The invention also provides methods, apparatuses and reagents useful for predicting future renal tubule injury based on expression levels of genes in the signatures. In one particular embodiment the invention provides a method for predict whether a compound will induce renal tubule injury using gene expression data from sub-acute treatments.
摘要翻译： 本发明公开了用于预测受试者肾小管损伤发作的试剂组和基因特征。 本发明还提供了可用于产生不同大小和性能的能够预测肾小管损伤发作的186个基因的必要组。 本发明还提供了基于签名中基因表达水平预测未来肾小管损伤的方法，装置和试剂。 在一个具体实施方案中，本发明提供了使用来自亚急性治疗的基因表达数据来预测化合物是否会诱导肾小管损伤的方法。
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公开(公告)号：US08716478B2
公开(公告)日：2014-05-06
申请号：US13015487
申请日：2011-01-27
申请人： Kurt Jarnagin , Tsutomu Akama
发明人： Kurt Jarnagin , Tsutomu Akama
摘要： Compounds, pharmaceutical formulations, and methods of treating anti-inflammatory conditions and/or helminth-associated diseases are disclosed.
摘要翻译： 公开了化合物，药物制剂和治疗抗炎症状和/或蠕虫相关疾病的方法。
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公开(公告)号：US20110166104A1
公开(公告)日：2011-07-07
申请号：US13062491
申请日：2009-09-02
申请人： Yasheen Zhou , Yong Kang Zhang , Tsutomu Akama , Kurt Jarnagin
发明人： Yasheen Zhou , Yong Kang Zhang , Tsutomu Akama , Kurt Jarnagin
IPC分类号： A61K31/69 , C07F5/02 , C12N9/99 , A61P27/06 , A61P9/00 , A61P35/00 , A61P25/28 , A61P13/12 , A61P11/06 , A61P19/10 , A61P15/10 , A61P7/00 , A61P21/00
CPC分类号： A61K31/69 , A61K45/06 , C07F5/025 , Y02A50/411 , A61K2300/00
摘要： This invention provides, among other things, novel compounds useful for treating inflammatory conditions, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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公开(公告)号：US08461336B2
公开(公告)日：2013-06-11
申请号：US13062491
申请日：2009-09-02
申请人： Yasheen Zhou , Yong Kang Zhang , Tsutomu Akama , Kurt Jarnagin
发明人： Yasheen Zhou , Yong Kang Zhang , Tsutomu Akama , Kurt Jarnagin
CPC分类号： A61K31/69 , A61K45/06 , C07F5/025 , Y02A50/411 , A61K2300/00
摘要： This invention provides, among other things, novel compounds useful for treating inflammatory conditions, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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7.发明申请SYSTEMS AND METHODS FOR REMOTE COMPUTER-BASED ANALYSIS OF USER-PROVIDED CHEMOGENOMIC DATA 审中-公开用于远程计算机分析用户提供的化学数据的系统和方法公开(公告)号：US20070198653A1
公开(公告)日：2007-08-23
申请号：US11614823
申请日：2006-12-21
申请人： Kurt Jarnagin , Georges Natsoulis , Richard Brennan , Brigitte Ganter Seghezzi , Alexander Tolley
发明人： Kurt Jarnagin , Georges Natsoulis , Richard Brennan , Brigitte Ganter Seghezzi , Alexander Tolley
IPC分类号： G06F15/16
摘要： The invention provides systems and methods for remote computer-based analysis of user provided chemogenomic data. The invention includes computer-based systems and software that allow a remote user to access a centralized comprehensive chemogenomic database and use the correlative tools of that database to assess the user's data. The tools allow the user to generate a summary report of the chemogenomic/toxicogenomic analysis results obtained using the chemogenomic database.
摘要翻译： 本发明提供用于远程计算机分析用户提供的化学基因组数据的系统和方法。 本发明包括基于计算机的系统和软件，其允许远程用户访问集中的综合化学基因组数据库并使用该数据库的相关工具来评估用户的数据。 这些工具允许用户生成使用化学基因组数据库获得的化学基因组/毒素基因组分析结果的总结报告。
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公开(公告)号：US20060057066A1
公开(公告)日：2006-03-16
申请号：US11184272
申请日：2005-07-18
申请人： Georges Natsoulis , Mark Fielden , Kurt Jarnagin , Kyle Kolaja
发明人： Georges Natsoulis , Mark Fielden , Kurt Jarnagin , Kyle Kolaja
CPC分类号： G01N33/6893 , G01N2500/00 , G01N2800/347
摘要： The invention discloses reagent sets and gene signatures for predicting onset of renal tubule injury in a subject. The invention also provides a necessary set of 186 genes useful for generating signatures of varying size and performance capable of predicting onset of renal tubule injury. The invention also provides methods, apparatuses and reagents useful for predicting future renal tubule injury based on expression levels of genes in the signatures. In one particular embodiment the invention provides a method for predict whether a compound will induce renal tubule injury using gene expression data from sub-acute treatments.
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