公开(公告)号：US07402566B2

公开(公告)日：2008-07-22

申请号：US10944480

申请日：2004-09-17

Applicant: Ethan Bier ,  Kweon Yu

Inventor： Ethan Bier ,  Kweon Yu

IPC: C07K14/475 ,  A61K38/18

CPC classification number: C07K14/43581 ,  C07H21/02 ,  Y10S530/858

Abstract: A potent peptide inhibitor (SuperSog) of TGF-β family growth factor signaling, peptide variants thereof and nucleotide coding sequences therefore are provided by the invention. The Super-Sog peptide comprises a fragment of the Drosophilia short gastrulation (Sog) gene which includes the CR-1 cysteine-rich repeat of Sog. Methods and compositions for use of Super-Sog in therapeutic and diagnostic applications are also provided.

Abstract translation: 因此，本发明提供了TGF-β家族生长因子信号传导的有效肽抑制剂（SuperSog），其肽变体和核苷酸编码序列。 超级谷氨肽包含果糖的富含CR-1半胱氨酸的重复序列的果蝇短胃蛋白（Sog）基因的片段。 还提供了在治疗和诊断应用中使用Super-Sog的方法和组合物。

公开(公告)号：US20060003929A1

公开(公告)日：2006-01-05

申请号：US10944480

申请日：2004-09-17

Applicant: Ethan Bier ,  Kweon Yu

Inventor： Ethan Bier ,  Kweon Yu

IPC: A61K38/18 ,  C07K14/475

CPC classification number: C07K14/43581 ,  C07H21/02 ,  Y10S530/858

Abstract: A potent peptide inhibitor (SuperSog) of TGF-β family growth factor signaling, peptide variants thereof and nucleotide coding sequences therefore are provided by the invention. The Super-Sog peptide comprises a fragment of the Drosophilia short gastrulation (Sog) gene which includes the CR-1 cysteine-rich repeat of Sog. Methods and compositions for use of Super-Sog in therapeutic and diagnostic applications are also provided.

Abstract translation: 因此，本发明提供了TGF-β家族生长因子信号传导的有效肽抑制剂（SuperSog），其肽变体和核苷酸编码序列。 超级谷氨肽包含果糖的富含CR-1半胱氨酸的重复序列的果蝇短胃蛋白（Sog）基因的片段。 还提供了在治疗和诊断应用中使用Super-Sog的方法和组合物。

公开(公告)号：US06806358B1

公开(公告)日：2004-10-19

申请号：US09215569

申请日：1998-12-16

Applicant: Ethan Bier ,  Kweon Yu

Inventor： Ethan Bier ,  Kweon Yu

IPC: C07H2102

CPC classification number: C07K14/43581 ,  C07H21/02 ,  Y10S530/858

Abstract: A potent peptide inhibitor (SuperSog) of TGF-&bgr; family growth factor signalling, peptide variants thereof and nucleotide coding sequences therefor are provided by the invention. The Super-Sog peptide comprises a fragment of the Drosophilia short gastrulation (Sog) gene which includes the CR-1 cysteine-rich repeat of Sog. Methods and compositions for use of Super-Sog in therapeutic and diagnostic applications are also provided.

Abstract translation: 本发明提供TGF-β家族生长因子信号传导的有效肽抑制剂（SuperSog），其肽变体及其核苷酸编码序列。 超级谷氨肽包含果糖的富含CR-1半胱氨酸的重复序列的果蝇短胃蛋白（Sog）基因的片段。 还提供了在治疗和诊断应用中使用Super-Sog的方法和组合物。