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公开(公告)号：US20070186291A1
公开(公告)日：2007-08-09
申请号：US11726100
申请日：2007-03-20
Applicant: Ethan Bier , Annabel Guichard , Shaila Srinivasan
Inventor： Ethan Bier , Annabel Guichard , Shaila Srinivasan
IPC: A01K67/033
CPC classification number: A01K67/0339 , A01K67/033 , A01K2217/05 , A01K2227/706 , A01K2267/03 , C07K14/34 , C12N15/8509
Abstract: Methods for generating and using novel overexpression activity alleles of a gene in any organism, especially Drosophilia, are provided. Such alleles may be utilized in screening assays, and used to generate dominant-negative forms of bacterial toxins.
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Patent Agency Ranking
2.发明授权Method for generating overexpression of alleles in genes of unknown function 失效在未知功能基因中产生等位基因过表达的方法公开(公告)号：US07692059B2
公开(公告)日：2010-04-06
申请号：US11726100
申请日：2007-03-20
Applicant: Ethan Bier , Annabel Guichard , Shaila Srinivasan
Inventor： Ethan Bier , Annabel Guichard , Shaila Srinivasan
IPC: C12P21/00 , A01K67/033
CPC classification number: A01K67/0339 , A01K67/033 , A01K2217/05 , A01K2227/706 , A01K2267/03 , C07K14/34 , C12N15/8509
Abstract: Methods for generating and using novel overexpression activity alleles of a gene in any organism, especially Drosophilia, are provided. Such alleles may be utilized in screening assays, and used to generate dominant-negative forms of bacterial toxins.
Abstract translation: 提供了在任何生物体中产生和使用基因的新的过表达活性等位基因的方法，特别是果蝇。 这样的等位基因可用于筛选测定，并用于产生显性负性形式的细菌毒素。
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公开(公告)号：US07402566B2
公开(公告)日：2008-07-22
申请号：US10944480
申请日：2004-09-17
Applicant: Ethan Bier , Kweon Yu
Inventor： Ethan Bier , Kweon Yu
IPC: C07K14/475 , A61K38/18
CPC classification number: C07K14/43581 , C07H21/02 , Y10S530/858
Abstract: A potent peptide inhibitor (SuperSog) of TGF-β family growth factor signaling, peptide variants thereof and nucleotide coding sequences therefore are provided by the invention. The Super-Sog peptide comprises a fragment of the Drosophilia short gastrulation (Sog) gene which includes the CR-1 cysteine-rich repeat of Sog. Methods and compositions for use of Super-Sog in therapeutic and diagnostic applications are also provided.
Abstract translation: 因此，本发明提供了TGF-β家族生长因子信号传导的有效肽抑制剂（SuperSog），其肽变体和核苷酸编码序列。 超级谷氨肽包含果糖的富含CR-1半胱氨酸的重复序列的果蝇短胃蛋白（Sog）基因的片段。 还提供了在治疗和诊断应用中使用Super-Sog的方法和组合物。
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4.发明授权Method for generating overexpression of alleles in genes of unknown function 有权在未知功能基因中产生等位基因过表达的方法公开(公告)号：US07193126B2
公开(公告)日：2007-03-20
申请号：US10263367
申请日：2002-10-01
Applicant: Ethan Bier , Annabel Guichard , Shaila Srinivasan
Inventor： Ethan Bier , Annabel Guichard , Shaila Srinivasan
IPC: A01K67/033
CPC classification number: A01K67/0339 , A01K67/033 , A01K2217/05 , A01K2227/706 , A01K2267/03 , C07K14/34 , C12N15/8509
Abstract: Methods for generating and using novel overexpression activity alleles of a gene in any organism, especially Drosophilia, are provided. Such alleles may be utilized in screening assays, and used to generate dominant-negative forms of bacterial toxins.
Abstract translation: 提供了在任何生物体中产生和使用基因的新的过表达活性等位基因的方法，特别是果蝇。 这样的等位基因可用于筛选测定，并用于产生显性负性形式的细菌毒素。
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公开(公告)号：US06806358B1
公开(公告)日：2004-10-19
申请号：US09215569
申请日：1998-12-16
Applicant: Ethan Bier , Kweon Yu
Inventor： Ethan Bier , Kweon Yu
IPC: C07H2102
CPC classification number: C07K14/43581 , C07H21/02 , Y10S530/858
Abstract: A potent peptide inhibitor (SuperSog) of TGF-&bgr; family growth factor signalling, peptide variants thereof and nucleotide coding sequences therefor are provided by the invention. The Super-Sog peptide comprises a fragment of the Drosophilia short gastrulation (Sog) gene which includes the CR-1 cysteine-rich repeat of Sog. Methods and compositions for use of Super-Sog in therapeutic and diagnostic applications are also provided.
Abstract translation: 本发明提供TGF-β家族生长因子信号传导的有效肽抑制剂（SuperSog），其肽变体及其核苷酸编码序列。 超级谷氨肽包含果糖的富含CR-1半胱氨酸的重复序列的果蝇短胃蛋白（Sog）基因的片段。 还提供了在治疗和诊断应用中使用Super-Sog的方法和组合物。
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公开(公告)号：US20060003929A1
公开(公告)日：2006-01-05
申请号：US10944480
申请日：2004-09-17
Applicant: Ethan Bier , Kweon Yu
Inventor： Ethan Bier , Kweon Yu
IPC: A61K38/18 , C07K14/475
CPC classification number: C07K14/43581 , C07H21/02 , Y10S530/858
Abstract: A potent peptide inhibitor (SuperSog) of TGF-β family growth factor signaling, peptide variants thereof and nucleotide coding sequences therefore are provided by the invention. The Super-Sog peptide comprises a fragment of the Drosophilia short gastrulation (Sog) gene which includes the CR-1 cysteine-rich repeat of Sog. Methods and compositions for use of Super-Sog in therapeutic and diagnostic applications are also provided.
Abstract translation: 因此，本发明提供了TGF-β家族生长因子信号传导的有效肽抑制剂（SuperSog），其肽变体和核苷酸编码序列。 超级谷氨肽包含果糖的富含CR-1半胱氨酸的重复序列的果蝇短胃蛋白（Sog）基因的片段。 还提供了在治疗和诊断应用中使用Super-Sog的方法和组合物。
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