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    Stable liquid compositions for treating stomatitis comprising epidermal growth factor
    1.
    发明授权
    Stable liquid compositions for treating stomatitis comprising epidermal growth factor 有权
    用于治疗包含表皮生长因子的口腔炎的稳定液体组合物

    公开(公告)号：US09155697B2

    公开(公告)日：2015-10-13

    申请号：US12444961

    申请日：2007-10-09

    申请人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

    发明人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

    IPC分类号： A61K38/18 ,  C07K14/485 ,  A61K9/00 ,  A61K47/10

    CPC分类号： A61K9/006 ,  A61K38/1808 ,  A61K47/10 ,  C07K14/485

    摘要： Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.

    摘要翻译： 本发明提供一种用于治疗口腔炎的液体组合物，该液体组合物包括：表皮生长因子; 粘合剂聚合物; 和选自乙二胺四乙酸（EDTA）及其盐，组氨酸，赖氨酸及其无机酸盐，精氨酸及其无机酸盐和右旋糖酐的至少一种稳定剂。 液体组合物包括选自EDTA（或其盐）和某些氨基酸（或其无机酸盐）的稳定剂，因此可以显着增加表皮生长因子的物理化学和生物学稳定性。 因此，液体组合物可以长期储存和分配。 稳定化的组合物包括粘合剂聚合物，因此当以使用者口中喷雾形式喷射时，液体组合物可以快速地附着于炎症部位并且长时间显示出有效性。

    Nanoliposome using esterified lecithin and method for preparing the same, and composition for preventing or treating skin diseases comprising the same
    2.
    发明授权
    Nanoliposome using esterified lecithin and method for preparing the same, and composition for preventing or treating skin diseases comprising the same 有权
    使用酯化卵磷脂的纳米脂质体及其制备方法，以及用于预防或治疗包含其的皮肤病的组合物

    公开(公告)号：US08685440B2

    公开(公告)日：2014-04-01

    申请号：US12375739

    申请日：2007-08-01

    申请人： Joon Pio Hong ,  Sang Kil Lee ,  Won Chul Kim ,  Chae Ha Yoon ,  Sang Wook Lee ,  Kyeong Sun Shin ,  Seung Kook Park

    发明人： Joon Pio Hong ,  Sang Kil Lee ,  Won Chul Kim ,  Chae Ha Yoon ,  Sang Wook Lee ,  Kyeong Sun Shin ,  Seung Kook Park

    IPC分类号： A61K36/00 ,  A61K9/127 ,  A61K8/14 ,  A61K8/55

    CPC分类号： A61K9/1271 ,  A61K8/14 ,  A61K8/553 ,  A61K9/1277 ,  A61K2800/413 ,  A61Q19/00 ,  B82Y5/00

    摘要： The present invention relates to a nanoliposome comprising a liposome membrane containing esterified lecithin, and one or more physiologically active ingredients included in inner space of the liposome membrane; a method for preparing the same; and a composition for preventing or treating skin diseases, comprising the same. The nanoliposome according to the present invention has long-term stability and uniformity, and so can be used to prepare a composition for skin having excellent moisturizing and penetrating properties, such as cosmetics, medicament for treating skin diseases, or the like. In particular, the present composition for preventing or treating skin diseases comprises epidermal growth factor included in the nanoliposome, thereby showing an excellent effect of stimulating skin-penetration and good pharmaceutical stability. Also, the esterified lecithin used in preparing liposome can provide effects of softening skin and stimulating skin-penetration, thereby enhancing the penetration of epidermal growth factor and natural extract into skin, as well as additional moisturizing effect which is advantageous in treating skin diseases. Further, since the present composition comprises nanoliposome prepared by containing esterified lecithin in liposome membrane, the conventional problems of heating and dispersing active ingredients at high temperature (70° C. or more), low stability and uniformity, or the like can be solved.

    摘要翻译： 本发明涉及包含含有酯化卵磷脂的脂质体膜和包含在脂质体膜的内部空间中的一种或多种生理活性成分的纳米脂质体， 其制备方法; 以及用于预防或治疗皮肤病的组合物。 根据本发明的纳米脂质体具有长期的稳定性和均匀性，因此可以用于制备具有优异的保湿和渗透性的皮肤组合物，例如化妆品，用于治疗皮肤病的药物等。 特别地，本发明的皮肤病预防或治疗组合物包括纳米脂质体中所含的表皮生长因子，因此显示刺激皮肤渗透和良好药物稳定性的优异效果。 此外，用于制备脂质体的酯化卵磷脂可以提供软化皮肤和刺激皮肤渗透的作用，从而增强表皮生长因子和天然提取物对皮肤的渗透性，以及有利于治疗皮肤疾病的额外的保湿效果。 此外，由于本发明的组合物包含通过在脂质体膜中含有酯化的卵磷脂而制备的纳米脂质体，因此可以解决在高温（70℃以上）下加热分散有效成分的常规问题，稳定性和均匀性低等。

    Nanoliposome Using Esterified Lecithin And Method For Preparing The Same, And Composition For Preventing Or Treating Skin Diseases Comprising The Same
    3.
    发明申请
    Nanoliposome Using Esterified Lecithin And Method For Preparing The Same, And Composition For Preventing Or Treating Skin Diseases Comprising The Same 有权
    使用酯化卵磷脂的纳米脂质体及其制备方法，以及用于预防或治疗包含其的皮肤疾病的组合物

    公开(公告)号：US20090263473A1

    公开(公告)日：2009-10-22

    申请号：US12375739

    申请日：2007-08-01

    申请人： Joon Pio Hong ,  Sang Kil Lee ,  Won Chul Kim ,  Chae Ha Yoon ,  Sang Wook Lee ,  Kyeong Sun Shin ,  Seung Kook Park

    发明人： Joon Pio Hong ,  Sang Kil Lee ,  Won Chul Kim ,  Chae Ha Yoon ,  Sang Wook Lee ,  Kyeong Sun Shin ,  Seung Kook Park

    IPC分类号： A61K9/127 ,  A61K38/43 ,  A61K36/00

    CPC分类号： A61K9/1271 ,  A61K8/14 ,  A61K8/553 ,  A61K9/1277 ,  A61K2800/413 ,  A61Q19/00 ,  B82Y5/00

    摘要： The present invention relates to a nanoliposome comprising a liposome membrane containing esterified lecithin, and one or more physiologically active ingredients included in inner space of the liposome membrane; a method for preparing the same; and a composition for preventing or treating skin diseases, comprising the same. The nanoliposome according to the present invention has long-term stability and uniformity, and so can be used to prepare a composition for skin having excellent moisturizing and penetrating properties, such as cosmetics, medicament for treating skin diseases, or the like. In particular, the present composition for preventing or treating skin diseases comprises epidermal growth factor included in the nanoliposome, thereby showing an excellent effect of stimulating skin-penetration and good pharmaceutical stability. Also, the esterified lecithin used in preparing liposome can provide effects of softening skin and stimulating skin-penetration, thereby enhancing the penetration of epidermal growth factor and natural extract into skin, as well as additional moisturizing effect which is advantageous in treating skin diseases. Further, since the present composition comprises nanoliposome prepared by containing esterified lecithin in liposome membrane, the conventional problems of heating and dispersing active ingredients at high temperature (70° C. or more), low stability and uniformity, or the like can be solved.

    摘要翻译： 本发明涉及包含含有酯化卵磷脂的脂质体膜和包含在脂质体膜的内部空间中的一种或多种生理活性成分的纳米脂质体， 其制备方法; 以及用于预防或治疗皮肤病的组合物。 根据本发明的纳米脂质体具有长期的稳定性和均匀性，因此可以用于制备具有优异的保湿和渗透性的皮肤组合物，例如化妆品，用于治疗皮肤病的药物等。 特别地，本发明的皮肤病预防或治疗组合物包括纳米脂质体中所含的表皮生长因子，因此显示刺激皮肤渗透和良好药物稳定性的优异效果。 此外，用于制备脂质体的酯化卵磷脂可以提供软化皮肤和刺激皮肤渗透的作用，从而增强表皮生长因子和天然提取物对皮肤的渗透性，以及有利于治疗皮肤疾病的额外的保湿作用。 此外，由于本发明的组合物包含通过在脂质体膜中含有酯化的卵磷脂而制备的纳米脂质体，因此可以解决在高温（70℃以上）下加热分散有效成分的常规问题，稳定性和均匀性低等。

    STABLE LIQUID COMPOSITIONS FOR TREATING STOMATITIS COMPRISING EPIDERMAL GROWTH FACTOR
    5.
    发明申请
    STABLE LIQUID COMPOSITIONS FOR TREATING STOMATITIS COMPRISING EPIDERMAL GROWTH FACTOR 有权
    稳定液体组合物，用于处理包含生物生长因子的STOMATITI

    公开(公告)号：US20100035809A1

    公开(公告)日：2010-02-11

    申请号：US12444961

    申请日：2007-10-09

    申请人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

    发明人： Sun-Hee Kim ,  Sang-Kil Lee ,  Chae-Ha Yoon ,  Sun-Mee Yang ,  Sang-Hyun Nam ,  Kyeong-Sun Shin ,  Seung-Kook Park ,  Sang-Wook Lee

    IPC分类号： A61K38/18

    CPC分类号： A61K9/006 ,  A61K38/1808 ,  A61K47/10 ,  C07K14/485

    摘要： Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.

    摘要翻译： 本发明提供一种用于治疗口腔炎的液体组合物，该液体组合物包括：表皮生长因子; 粘合剂聚合物; 和选自乙二胺四乙酸（EDTA）及其盐，组氨酸，赖氨酸及其无机酸盐，精氨酸及其无机酸盐和右旋糖酐的至少一种稳定剂。 液体组合物包括选自EDTA（或其盐）和某些氨基酸（或其无机酸盐）的稳定剂，因此可以显着增加表皮生长因子的物理化学和生物学稳定性。 因此，液体组合物可以长期储存和分配。 稳定化的组合物包括粘合剂聚合物，因此当以使用者口中喷雾形式喷射时，液体组合物可以快速地附着于炎症部位并且长时间显示出有效性。