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公开(公告)号：US20140079759A1
公开(公告)日：2014-03-20
申请号：US13988491
申请日：2011-12-02
申请人： Shyam Patel , Kyle Kurpinski
发明人： Shyam Patel , Kyle Kurpinski
IPC分类号： A61K9/70 , A61K45/06 , A61K31/765
CPC分类号： A61K9/70 , A61K31/765 , A61K45/06 , A61L27/50 , A61L27/54 , A61L2300/64 , D01D5/0076 , D01F1/10
摘要： Fibrous polymer scaffolds having at least one layer of diametrically patterned fibers, as well as methods of manufacture, are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled. Fabrication systems and methods for producing such scaffolds including apparatuses and processes are also provided.
摘要翻译： 提供具有至少一层直径图案化纤维的纤维聚合物支架以及制造方法。 支架可以由多层形成，并且可以控制各层的对准程度和方向。 还提供了用于生产这种支架的制造系统和方法，包括装置和工艺。
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公开(公告)号：US20070269481A1
公开(公告)日：2007-11-22
申请号：US11668448
申请日：2007-01-29
申请人： Song Li , Shyam Patel , Craig Hashi , Ngan Huang , Kyle Kurpinski
发明人： Song Li , Shyam Patel , Craig Hashi , Ngan Huang , Kyle Kurpinski
IPC分类号： A61F2/06 , A61K31/727 , A61K31/728 , B27N3/28 , D01D5/10
CPC分类号： A61L27/18 , A61L27/50 , A61L2430/36 , C12M21/08 , C12M25/14 , D01D5/0076 , D10B2509/00 , C08L67/04 , C08L71/02
摘要： The invention provides a composition comprising a nanofiber polymer in which the fibers of the nanofiber polymer are aligned, and a molecule is covalently attached, either directly or through a linker, to the nanofiber polymer. This molecule is capable of either covalently or non-covalently attaching to a member selected from an extracellular matrix component, a growth factor, and combinations thereof. The invention also provides methods of making the composition and methods of using the compositions to add new tissue to a subject, such as a human.
摘要翻译： 本发明提供一种包含纳米纤维聚合物的组合物，其中纳米纤维聚合物的纤维与纳米纤维聚合物直接或通过连接体共价连接分子。 该分子能够共价或非共价连接至选自细胞外基质组分，生长因子及其组合的成员。 本发明还提供了使组合物和使用组合物向受试者（例如人）添加新组织的方法。
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3.发明授权Multilayer fibrous polymer scaffolds, methods of production and methods of use 有权多层纤维聚合物支架，生产方法和使用方法公开(公告)号：US08852621B2
公开(公告)日：2014-10-07
申请号：US12575432
申请日：2009-10-07
申请人： Shyam Patel , Kyle Kurpinski , Yinki Clement Wong
发明人： Shyam Patel , Kyle Kurpinski , Yinki Clement Wong
CPC分类号： A61L27/26 , A61L15/26 , A61L27/18 , A61L27/54 , A61L2430/00 , D01D5/0076 , C08L67/04 , C08L71/02
摘要： Fibrous polymer scaffolds and methods of manufacture are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled. Efficient fabrication systems and methods for producing such scaffolds include apparatuses and processes are also provided. Kits including the fibrous polymer scaffolds and methods for implanting such scaffolds are also provided.
摘要翻译： 提供纤维聚合物支架和制造方法。 支架可以由多层形成，并且可以控制各层的对准程度和方向。 还提供了用于生产这种支架的高效制造系统和方法，包括装置和工艺。 还提供了包括纤维聚合物支架和用于植入这种支架的方法的试剂盒。
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4.发明授权公开(公告)号：US09168231B2
公开(公告)日：2015-10-27
申请号：US13988491
申请日：2011-12-02
申请人： Shyam Patel , Kyle Kurpinski
发明人： Shyam Patel , Kyle Kurpinski
IPC分类号： B29C47/00 , A61L15/00 , A61L15/16 , A61K38/00 , D01D5/00 , A61K9/70 , A61L27/50 , A61L27/54 , D01F1/10 , A61K31/765 , A61K45/06
CPC分类号： A61K9/70 , A61K31/765 , A61K45/06 , A61L27/50 , A61L27/54 , A61L2300/64 , D01D5/0076 , D01F1/10
摘要： Fibrous polymer scaffolds having at least one layer of diametrically patterned fibers, as well as methods of manufacture, are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled. Fabrication systems and methods for producing such scaffolds including apparatuses and processes are also provided.
摘要翻译： 提供具有至少一层直径图案化纤维的纤维聚合物支架以及制造方法。 支架可以由多层形成，并且可以控制各层的对准程度和方向。 还提供了用于生产这种支架的制造系统和方法，包括装置和工艺。
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5.发明申请Multilayer Fibrous Polymer Scaffolds, Methods of Production and Methods of Use 有权多层纤维聚合物支架，生产方法和使用方法公开(公告)号：US20100233115A1
公开(公告)日：2010-09-16
申请号：US12575432
申请日：2009-10-07
申请人： Shyam Patel , Kyle Kurpinski , Yinki Clement Wong
发明人： Shyam Patel , Kyle Kurpinski , Yinki Clement Wong
CPC分类号： A61L27/26 , A61L15/26 , A61L27/18 , A61L27/54 , A61L2430/00 , D01D5/0076 , C08L67/04 , C08L71/02
摘要： Fibrous polymer scaffolds and methods of manufacture are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled. Efficient fabrication systems and methods for producing such scaffolds include apparatuses and processes are also provided. Kits including the fibrous polymer scaffolds and methods for implanting such scaffolds are also provided.
摘要翻译： 提供纤维聚合物支架和制造方法。 支架可以由多层形成，并且可以控制各层的对准程度和方向。 还提供了用于生产这种支架的高效制造系统和方法，包括装置和工艺。 还提供了包括纤维聚合物支架和用于植入这种支架的方法的试剂盒。
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