公开(公告)号：US08883226B2

公开(公告)日：2014-11-11

申请号：US13985533

申请日：2012-02-07

申请人： Sei Ryang Oh ,  Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Hyeong Kyu Lee ,  Joongku Lee ,  Hyouk Joung ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-youl Lee ,  Sang Woo Lee ,  Hang Jin ,  Wan Yi Li

发明人： Sei Ryang Oh ,  Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Hyeong Kyu Lee ,  Joongku Lee ,  Hyouk Joung ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-youl Lee ,  Sang Woo Lee ,  Hang Jin ,  Wan Yi Li

IPC分类号： A61K36/31

CPC分类号： A61K36/61

摘要： A pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma comprising the extract of Decaspermum fruticosum as an active ingredient. The extract of Decaspermum fruticosum of the present invention inhibited the increase of eosinophils in bronchoalveolar lavage fluid of the ovalbumin induced asthma animal model, had the activity of inhibiting the secretions of immunoglobulin and chemokine (Eotaxin) in bronchoalveolar lavage fluid and blood, and inhibited the secretions of NO and TNF-α in macrophages. Therefore, the extract of Decaspermum fruticosum of the present invention can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma, and of a health functional food for the prevention and improvement of inflammatory disease or asthma.

摘要翻译： 一种用于预防和治疗炎症性疾病或哮喘的药物组合物，其包含作为活性成分的Dececpermum fruticosum的提取物。 本发明的Decaspermum fruticosum的提取物抑制卵清蛋白诱导的哮喘动物模型的支气管肺泡灌洗液中嗜酸性粒细胞的增加，具有抑制支气管肺泡灌洗液和血液中免疫球蛋白和趋化因子（Eotaxin）分泌的活性，并抑制 巨噬细胞中NO和TNF-α的分泌。 因此，本发明的Decaspermum fruticosum的提取物可以有效地用作预防和治疗炎性疾病或哮喘的药物组合物的活性成分，以及用于预防和改善炎性疾病或哮喘的健康功能食品 。

公开(公告)号：US20130164395A1

公开(公告)日：2013-06-27

申请号：US13820474

申请日：2011-08-30

申请人： Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Sei Ryang Oh ,  Jung Hee Kim ,  Hyeong Kyu Lee ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-Youl Lee ,  Soo Yong Kim ,  Giselle Tomayo-Castillo ,  Katia Rosales-Ovares ,  Rodrigo Gamez-Lobo

发明人： Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Sei Ryang Oh ,  Jung Hee Kim ,  Hyeong Kyu Lee ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-Youl Lee ,  Soo Yong Kim ,  Giselle Tomayo-Castillo ,  Katia Rosales-Ovares ,  Rodrigo Gamez-Lobo

IPC分类号： A61K36/44

CPC分类号： A61K36/44

摘要： Disclosed is a pharmaceutical composition for the prophylaxis and therapy of inflammatory diseases, allergic diseases, or asthma, comprising a velvet apple (Diospyros blancoi A. DC.) extract as an active ingredient. Having the inhibitory activity against the nuclear translocation of NF-κB, whose level is rapidly elevated in response to inflammatory stimuli, the velvet apple extract can suppress the production of NO and PGE2, the expression of iNOS and COX-2, and the release of IL-1β and TNF-α, and can significantly down regulate Th2-mediated IL-4 and IL-13 production. In addition, the extract was found to inhibit the activation of eosinophils in bronchoalveolar lavage fluid, and to suppress the secretion of immunoglobulins and chemokines in bronchoalveolar lavage fluid and blood, as measured by in vivo tests on an ovalbumin-induced asthma mouse model. Therefore, the extract can be used in the method for preventing or treating various inflammatory disorders, allergic diseases, or asthma.

摘要翻译： 公开了一种用于预防和治疗炎性疾病，过敏性疾病或哮喘的药物组合物，其包含天鹅绒苹果（Diospyros blancoi A.DC。）提取物作为活性成分。 天鹅绒苹果提取物对NF-κB的核易位具有抑制作用，NF-κB的水平随着炎症刺激而迅速升高，可抑制NO和PGE2的产生，iNOS和COX-2的表达，以及释放 IL-1β和TNF-α，并能显着下调Th2介导的IL-4和IL-13产生。 此外，发现提取物抑制支气管肺泡灌洗液中嗜酸性粒细胞的活化，并且通过卵清蛋白诱导的哮喘小鼠模型的体内试验测量，抑制支气管肺泡灌洗液和血液中免疫球蛋白和趋化因子的分泌。 因此，提取物可用于预防或治疗各种炎性疾病，过敏性疾病或哮喘的方法。

公开(公告)号：US20230194164A1

公开(公告)日：2023-06-22

申请号：US17906337

申请日：2021-05-14

申请人： Kyoung Youl LEE

发明人： Kyoung Youl LEE

IPC分类号： F26B5/02 ,  F26B9/00 ,  A47G25/12

CPC分类号： F26B5/02 ,  F26B9/003 ,  A47G25/12 ,  F26B2210/10

摘要： A device for removing rainwater from an umbrella is disclosed. The device for removing rainwater from an umbrella comprises: a stand extending upward from a support; a holder for fixing an umbrella shaft; a driving apparatus coupled to the stand and for vibrating the holder; and a processor for controlling the vibration generated by the driving apparatus. The holder comprises: an opening; a fixing groove for fixing the umbrella shaft; and a support member for supporting the umbrella shaft from the opening to the fixing groove. The opening is open in the linear direction to the fixing groove such that the umbrella shaft is inserted in one direction from the opening to the fixing groove.

公开(公告)号：US08722110B2

公开(公告)日：2014-05-13

申请号：US13820474

申请日：2011-08-30

申请人： Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Sei Ryang Oh ,  Jung Hee Kim ,  Hyeong Kyu Lee ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-Youl Lee ,  Soo Yong Kim ,  Giselle Tomayo-Castillo ,  Katia Rosales-Ovares ,  Rodrigo Gamez-Lobo

发明人： Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Sei Ryang Oh ,  Jung Hee Kim ,  Hyeong Kyu Lee ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-Youl Lee ,  Soo Yong Kim ,  Giselle Tomayo-Castillo ,  Katia Rosales-Ovares ,  Rodrigo Gamez-Lobo

IPC分类号： A01N65/00

CPC分类号： A61K36/44

摘要： Disclosed is a pharmaceutical composition for the prophylaxis and therapy of inflammatory diseases, allergic diseases, or asthma, comprising a velvet apple (Diospyros blancoi A. DC.) extract as an active ingredient. Having the inhibitory activity against the nuclear translocation of NF-κB, whose level is rapidly elevated in response to inflammatory stimuli, the velvet apple extract can suppress the production of NO and PGE2, the expression of iNOS and COX-2, and the release of IL-1β and TNF-α, and can significantly down regulate Th2-mediated IL-4 and IL-13 production. In addition, the extract was found to inhibit the activation of eosinophils in bronchoalveolar lavage fluid, and to suppress the secretion of immunoglobulins and chemokines in bronchoalveolar lavage fluid and blood, as measured by in vivo tests on an ovalbumin-induced asthma mouse model. Therefore, the extract can be used in the method for preventing or treating various inflammatory disorders, allergic diseases, or asthma.

摘要翻译： 公开了一种用于预防和治疗炎性疾病，过敏性疾病或哮喘的药物组合物，其包含天鹅绒苹果（Diospyros blancoi A.DC。）提取物作为活性成分。 天鹅绒苹果提取物对NF-κB的核易位具有抑制活性，其水平迅速升高，可抑制NO和PGE2的产生，iNOS和COX-2的表达，以及 释放IL-1和bgr; 和TNF-α，并可显着下调Th2介导的IL-4和IL-13产生。 此外，发现提取物抑制支气管肺泡灌洗液中嗜酸性粒细胞的活化，并且通过卵清蛋白诱导的哮喘小鼠模型的体内试验测量，抑制支气管肺泡灌洗液和血液中免疫球蛋白和趋化因子的分泌。 因此，提取物可用于预防或治疗各种炎性疾病，过敏性疾病或哮喘的方法。

公开(公告)号：US20130323331A1

公开(公告)日：2013-12-05

申请号：US13985533

申请日：2012-02-07

申请人： Sei Ryang Oh ,  Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Hyeong Kyu Lee ,  Joongku Lee ,  Hyouk Joung ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-youl Lee ,  Sang Woo Lee ,  Hang Jin ,  Wan Yi Li

发明人： Sei Ryang Oh ,  Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Hyeong Kyu Lee ,  Joongku Lee ,  Hyouk Joung ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-youl Lee ,  Sang Woo Lee ,  Hang Jin ,  Wan Yi Li

IPC分类号： A61K36/61

CPC分类号： A61K36/61

摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma comprising the extract of Decaspermum fruticosum as an active ingredient. The extract of Decaspermum fruticosum of the present invention inhibited the increase of eosinophils in bronchoalveolar lavage fluid of the ovalbumin-induced asthma animal model, had the activity of inhibiting the secretions of immunoglobulin and chemokine (Eotaxin) in bronchoalveolar lavage fluid and blood, and inhibited the secretions of NO and TNF-α in macrophages. Therefore, the extract of Decaspermum fruticosum of the present invention can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma, and of a health functional food for the prevention and improvement of inflammatory disease or asthma.

摘要翻译： 本发明涉及一种用于预防和治疗炎症性疾病或哮喘的药物组合物，其包含作为活性成分的Dececpermum fruticosum的提取物。 本发明的Decaspermum fruticosum的提取物抑制卵清蛋白诱导的哮喘动物模型的支气管肺泡灌洗液中嗜酸性粒细胞的增加，具有抑制支气管肺泡灌洗液和血液中免疫球蛋白和趋化因子（Eotaxin）分泌的活性，并被抑制 NO和TNF-α在巨噬细胞中的分泌。 因此，本发明的Decaspermum fruticosum的提取物可以有效地用作预防和治疗炎性疾病或哮喘的药物组合物的活性成分，以及用于预防和改善炎性疾病或哮喘的健康功能食品 。