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31 条记录 (耗时 0.017 秒)

    Polymeric nanoparticles by ion-ion interactions
    1.
    发明申请
    Polymeric nanoparticles by ion-ion interactions 审中-公开
    通过离子 - 离子相互作用的聚合物纳米颗粒

    公开(公告)号：US20080160096A1

    公开(公告)日：2008-07-03

    申请号：US11881831

    申请日：2007-07-27

    申请人： Janos Berbely ,  Magdolna Bodnar ,  Istvan Hajdu ,  John F. Hartmann ,  Zsolt Keresztessy ,  Laszlo Nagy ,  Gyorgy Vamosi

    发明人： Janos Berbely ,  Magdolna Bodnar ,  Istvan Hajdu ,  John F. Hartmann ,  Zsolt Keresztessy ,  Laszlo Nagy ,  Gyorgy Vamosi

    IPC分类号： A61K9/50

    CPC分类号： A61K9/5138 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5036 ,  A61K9/5146 ,  A61K9/5161 ,  A61K9/5192 ,  C12N15/87

    摘要： The present invention relates to biocompatible and biodegradable stimuli-sensitive polymeric nanoparticles, which were formed by ion-ion interaction in aqueous media. Synthetic and biological macromolecules with ionizable functional groups are capable of forming nanoparticles whose size and surface properties are sensitive to environmental influences such as pH, temperature and salt concentration. Nanodevices are designed for therapeutic applications as drug and nucleic acid carriers, and/or for MRI diagnosis as contrast agents. These nanodevices are designed for therapeutic applications as targeted drug carriers. Additionally, they can be used as contrast agents for MRI diagnosis. These nanosystems are also potential carriers for delivery of active ingredients as DNA, RNA, short interfering RNA (siRNA), antisense oligonucleotides (AS-ON), and triple helix forming oligonucleotides (TFO) etc. for pharmaceutical applications. Their adjustable size offers yet another advantage.

    摘要翻译： 本发明涉及生物相容性和生物可降解的刺激性敏感的聚合物纳米粒子，其通过在水性介质中的离子 - 离子相互作用而形成。 具有可离子化官能团的合成和生物大分子能够形成尺寸和表面性质对pH，温度和盐浓度等环境影响敏感的纳米颗粒。 纳米设备设计用作药物和核酸载体的治疗应用，和/或作为造影剂的MRI诊断。 这些纳米设备被设计用作靶向药物载体的治疗应用。 此外，它们可以用作MRI诊断的造影剂。 这些纳米系统也是作为药物应用的DNA，RNA，短干扰RNA（siRNA），反义寡核苷酸（AS-ON）和三螺旋形成寡核苷酸（TFO）等递送活性成分的潜在载体。 它们的可调节尺寸提供了另一个优点。

    Lamp caps for halogen lamps and the like
    2.
    发明授权
    Lamp caps for halogen lamps and the like 失效
    卤素灯等的灯头

    公开(公告)号：US4013335A

    公开(公告)日：1977-03-22

    申请号：US592793

    申请日：1975-07-02

    申请人： Laszlo Varkonyi ,  Gyorgy Szabo ,  Jozsef Orto ,  Laszlo Nagy ,  Janos Spielmann ,  Gyorgy Rabatin ,  Istvan Pozsonyi

    发明人： Laszlo Varkonyi ,  Gyorgy Szabo ,  Jozsef Orto ,  Laszlo Nagy ,  Janos Spielmann ,  Gyorgy Rabatin ,  Istvan Pozsonyi

    IPC分类号： H01J5/54 ,  H01J5/56

    CPC分类号： H01J5/54 ,  H01J5/56

    摘要： An improved construction for a lamp cap suitable for interconnecting the elongated constricted neck of a halogen lamp to an electrode-bearing lamp holder is described. A hollow elongated deformable insert is coaxially positioned within a conventional cover disc of the lamp cap. The interior dimension of the insert is chosen to effect a secure frictional engagement with at least 30% of the length of the constricted lamp neck, and is permanently or removably affixed to the surrounding cover disc. The lamp holder may then be affixed to the composite lamp cap to complete the assembly.

    摘要翻译： 描述了适用于将卤素灯的细长收缩颈部与电极轴承灯座相互连接的灯帽的改进结构。 中空细长可变形插入件同轴地定位在灯帽的传统盖盘内。 选择插入件的内部尺寸以实现与收缩的灯颈长度的至少30％的牢固的摩擦接合，并且永久地或可移除地固定到周围的盖盘上。 然后可以将灯座固定到复合灯帽以完成组装。

    Protective cast cover for bathing
    3.
    发明授权
    Protective cast cover for bathing 有权
    洗浴用保护套

    公开(公告)号：US08858476B2

    公开(公告)日：2014-10-14

    申请号：US13541227

    申请日：2012-07-03

    申请人： Cser Ferenc ,  Laszlo Nagy

    发明人： Cser Ferenc ,  Laszlo Nagy

    IPC分类号： A61F5/00 ,  A61F13/04

    CPC分类号： A61F13/041

    摘要： A cover adapted to be worn over a user's limb to shield a cast from water exposure includes a shell formed of a single layer of a flexible, water resistant and breathable material. The shell surrounds an interior of the cover, including a lower interior chamber and an upper interior chamber. An open top end communicates with the upper interior chamber and is sized to permit passage of the user's limb and the cast therethrough and into the upper and lower interior chambers. A cinch strap with a releasable securing mechanism closes the open top end around the user's limb. An inner cuff separating the interior chambers includes an elastomeric opening that fits snug against the user's limb, above the cast, and can be tightened using a secondary cinch strap and cooperating fasteners. A segment of water absorbing fabric on an interior surface for absorbing moisture and water.

    摘要翻译： 适于佩戴在使用者肢体上以防止水暴露的罩子包括由单层柔性防水和透气材料形成的壳体。 壳体围绕盖的内部，包括下部内部室和上部内部室。 开放的顶端与上部内部室相通，并且其尺寸设计成允许使用者的肢体和铸件通过其进入上部和下部内部腔室。 带有可释放固定机构的紧身皮带将用户肢体周围的开放顶端关闭。 分离内部腔室的内部套囊包括弹性体开口，该弹性体开口紧贴在使用者的肢体上方，并且可以使用次级束带和配合的紧固件紧固。 在内表面上吸收水分和水分的一段吸水织物。

    Disposable patient interface
    5.
    发明申请
    Disposable patient interface 有权
    一次性患者接口

    公开(公告)号：US20070093796A1

    公开(公告)日：2007-04-26

    申请号：US11258399

    申请日：2005-10-24

    申请人： Ferenc Raksi ,  Tibor Juhasz ,  Ron Kurtz ,  Wes Lummis ,  Chris Davis ,  Laszlo Nagy

    发明人： Ferenc Raksi ,  Tibor Juhasz ,  Ron Kurtz ,  Wes Lummis ,  Chris Davis ,  Laszlo Nagy

    IPC分类号： A61B18/18 ,  A61F9/008

    CPC分类号： A61F9/009 ,  A61B2017/306 ,  A61F9/008

    摘要： A patient interface device adapted to provide an interface between a cornea and a surgical laser system. A frame has an applanation end and an attachment end which is adapted to couple to the surgical laser system. A skirt is affixed to the applanation end of the frame and is adapted to seal against the anterior surface of the cornea to form a chamber. A lens is disposed near the applanation end of the frame and is supported by a flexible support which affixes the lens to the frame.

    摘要翻译： 一种适于提供角膜和外科激光系统之间的界面的患者接口装置。 框架具有压平端和适于联接到手术激光系统的附接端。 裙部固定在框架的压平端上并且适于密封角膜的前表面以形成腔室。 透镜设置在框架的压平端附近，并且由将镜片固定到框架的柔性支撑件支撑。

    Novel uses of PPAR modulators and professional APCs manipulated by the same
    6.
    发明申请
    Novel uses of PPAR modulators and professional APCs manipulated by the same 审中-公开
    PPAR调制器和专业APCs的新用途被操纵

    公开(公告)号：US20060159669A1

    公开(公告)日：2006-07-20

    申请号：US11273003

    申请日：2005-11-14

    申请人： Laszlo Nagy ,  Istvan Szatmari ,  Eva Rajnavolgyi ,  Peter Gogolak ,  Bence Rethi

    发明人： Laszlo Nagy ,  Istvan Szatmari ,  Eva Rajnavolgyi ,  Peter Gogolak ,  Bence Rethi

    IPC分类号： A61K48/00 ,  A61K39/00 ,  C12N5/08

    CPC分类号： C12N5/0639 ,  A61K47/6901 ,  A61K2035/122 ,  A61K2035/124 ,  C12N5/064 ,  C12N2501/385

    摘要： The invention relates to a manipulated professional antigen presenting cell (APC) having increased expression of a CD1 type II molecule, preferably at least a CD1d molecule, relative to a control non manipulated cell. The invention further relates to the use of PPARg modulators in the preparation of a pharmaceutical composition or kit for the treatment of a disease treatable by activation of CD1d restricted T-cells, e.g. in autoimmune diseases, allergies, post-transplant conditions or infectious diseases, or in the treatment of a neoplastic disease, e.g. skin cancer, hematological tumors, colorectal carcinoma, and therapeutic compositions and kits therefor. Furthermore, the invention relates to methods of manipulating professional APCs and kits therefor.

    摘要翻译： 本发明涉及相对于对照非操纵细胞具有增加的CD1型II分子表达，优选至少一种CD1d分子的操纵的专业抗原呈递细胞（APC）。 本发明还涉及PPARg调节剂在制备药物组合物或试剂盒中的用途，所述药物组合物或试剂盒用于治疗通过激活CD1d限制性T细胞可治疗的疾病，例如， 自身免疫性疾病，过敏症，移植后状况或感染性疾病，或治疗肿瘤性疾病，例如， 皮肤癌，血液肿瘤，结肠直肠癌，及其治疗组合物和试剂盒。 此外，本发明涉及操纵专业APC及其工具包的方法。

    Sustained release pharmaceutical compositions
    7.
    发明授权
    Sustained release pharmaceutical compositions 失效
    持续释放药物组合物

    公开(公告)号：US4539199A

    公开(公告)日：1985-09-03

    申请号：US384084

    申请日：1982-06-01

    申请人： Erno Orban ,  Janos Borvendeg ,  Laszlo Nagy ,  Marta Sotinee Tolvay ,  Erzsebet Bander

    发明人： Erno Orban ,  Janos Borvendeg ,  Laszlo Nagy ,  Marta Sotinee Tolvay ,  Erzsebet Bander

    IPC分类号： A61K47/48 ,  A01N25/12 ,  A61K31/78

    CPC分类号： A61K47/48176

    摘要： Pharmaceutical compositions for sustained release of pharmaceutical compounds comprising a reaction product of a water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group, and an alkali or ammonium salt of a synthetic copolymer containing an acid group, and selected from the group consisting of methacrylic acid/methacrylic acid methyl ester, methacrylic acid/acrylic acid methyl ester and methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers and a pharmaceutically acceptable excipient. The water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group is reacted in aqueous medium with an alkali or ammonium salt of a copolymer selected from the group consisting of the above mentioned copolymers, and the resulting product is converted into a pharmaceutical composition.

    摘要翻译： 用于持续释放药物组合物的药物组合物，其包含含有伯，仲或叔氨基的药物活性化合物的水溶性盐与含有酸基的合成共聚物的碱金属盐或铵盐的反应产物，并且选自 由甲基丙烯酸/甲基丙烯酸甲酯，甲基丙烯酸/丙烯酸甲酯和甲基丙烯酸/丙烯酸甲酯/甲基丙烯酸甲酯共​​聚物和药学上可接受的赋形剂组成的组。 含有伯，仲或叔氨基的药物活性化合物的水溶性盐在水性介质中与选自上述共聚物的共聚物的碱金属盐或铵盐反应，将所得产物转化为 药物组合物。

    ANISOTROPIC INCANDESCENT LIGHT SOURCE
    10.
    发明申请
    ANISOTROPIC INCANDESCENT LIGHT SOURCE 审中-公开
    各向异性光源

    公开(公告)号：US20130155707A1

    公开(公告)日：2013-06-20

    申请号：US13327167

    申请日：2011-12-15

    申请人： Istvan MUDRA ,  Laszlo Nagy ,  Jozsef Gallai

    发明人： Istvan MUDRA ,  Laszlo Nagy ,  Jozsef Gallai

    IPC分类号： B60Q1/04 ,  H01K1/14

    CPC分类号： H01K1/14

    摘要： An improved incandescent light source as may be used in a vehicle headlamp for providing forward illumination. The illuminating system includes a filament coil and an anisotropic reflector assembly. The filament coil is constructed from a coil of wire that is electrically conductive and has a high melting point and the primary axis of the coil of wire is substantially aligned with a principal axis of the reflector system. The light flux emitted by the filament coil toward the reflector system is rotationally anisotropic.

    摘要翻译： 一种改进的白炽光源，可用于车辆前照灯中以提供正向照明。 照明系统包括灯丝线圈和各向异性反射器组件。 灯丝线圈由导线的线圈构成，并且具有高熔点，线的线圈的主轴基本上与反射器系统的主轴对齐。 由灯丝线圈朝向反射器系统发射的光束是旋转各向异性的。